WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (35)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Finney, E. M.
Right arrow Articles by Shatz, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Finney, E. M.
Right arrow Articles by Shatz, C. J.

 Previous Article  |  Next Article 

The Journal of Neuroscience, November 1, 1998, 18(21):8826-8838

Establishment of Patterned Thalamocortical Connections Does Not Require Nitric Oxide Synthase

Eva M. Finney and Carla J. Shatz

Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, California 94720

Subplate neurons are early-generated neurons that project into the overlying neocortex and are required for the formation of ocular dominance columns. A subset of subplate neurons express nitric oxide synthase (NOS) and produce nitric oxide (NO), a neuronal messenger thought to be involved in adult hippocampal synaptic plasticity and also in the establishment of certain specific connections during visual system development. Here, we examine whether the NOS-containing subplate neurons are involved in ocular dominance column formation in the ferret visual system. Ocular dominance columns form in ferrets between postnatal day 35 (P35) and P60. NOS expression in the visual subplate is low at birth, increases to a maximum at the onset of ocular dominance column formation, and falls thereafter. Nevertheless, blockade of NOS with daily injections of nitroarginine from P14 to P56 fails to prevent the formation of ocular dominance columns, although NOS activity is reduced by >98%. To test further a requirement for NOS in the patterning of connections during CNS development, we examined the cortical barrels in the somatosensory system of mice carrying targeted disruptions of NOS that also received injections of nitroarginine; cortical barrels formed normally in these animals. In addition, barrel field plasticity induced by whisker ablation at birth was normal in nitroarginine-injected NOS knock-out mice. Thus, despite the dynamic regulation of NOS in subplate neurons, NO is unlikely to be essential for the patterning of thalamocortical connections either in visual or somatosensory systems.

Key words: ocular dominance columns; nitric oxide synthase; visual system; barrels; knock-out; nitroarginine; synaptic plasticity

Copyright © 1998 Society for Neuroscience  0270-6474/98/18218826-13$05.00/0


This article has been cited by other articles:


Home page
 Cereb CortexHome page
T. Imura, S. Kanatani, S. Fukuda, Y. Miyamoto, and T. Hisatsune
Layer-specific Production of Nitric Oxide during Cortical Circuit Formation in Postnatal Mouse Brain
Cereb Cortex, March 1, 2005; 15(3): 332 - 340.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. J. Bender, J. Rangel, and D. E. Feldman
Development of Columnar Topography in the Excitatory Layer 4 to Layer 2/3 Projection in Rat Barrel Cortex
J. Neurosci., September 24, 2003; 23(25): 8759 - 8770.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Cahana, T. Escamez, R. S. Nowakowski, N. L. Hayes, M. Giacobini, A. von Holst, O. Shmueli, T. Sapir, S. K. McConnell, W. Wurst, et al.
Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization
PNAS, May 3, 2001; (2001) 101122598.
[Abstract] [Full Text]

Home page
 ScienceHome page
J. C. Crowley and L. C. Katz
Early Development of Ocular Dominance Columns
Science, November 17, 2000; 290(5495): 1321 - 1324.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
M. L. Gabriele, J. K. Brunso-Bechtold, and C. K. Henkel
Plasticity in the Development of Afferent Patterns in the Inferior Colliculus of the Rat after Unilateral Cochlear Ablation
J. Neurosci., September 15, 2000; 20(18): 6939 - 6949.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. F. Ernst, G. Gallo, P. C. Letourneau, and S. C. McLoon
Stabilization of Growing Retinal Axons by the Combined Signaling of Nitric Oxide and Brain-Derived Neurotrophic Factor
J. Neurosci., February 15, 2000; 20(4): 1458 - 1469.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. P. Issa, J. T. Trachtenberg, B. Chapman, K. R. Zahs, and M. P. Stryker
The Critical Period for Ocular Dominance Plasticity in the Ferret's Visual Cortex
J. Neurosci., August 15, 1999; 19(16): 6965 - 6978.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. C. Renteria and M. Constantine-Paton
Nitric Oxide in the Retinotectal System: a Signal But Not a Retrograde Messenger During Map Refinement and Segregation
J. Neurosci., August 15, 1999; 19(16): 7066 - 7076.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Cahana, T. Escamez, R. S. Nowakowski, N. L. Hayes, M. Giacobini, A. von Holst, O. Shmueli, T. Sapir, S. K. McConnell, W. Wurst, et al.
Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization
PNAS, May 22, 2001; 98(11): 6429 - 6434.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-