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The Journal of Neuroscience, November 1, 1998, 18(21):8875-8885

Accumulation of F-Spondin in Injured Peripheral Nerve Promotes the Outgrowth of Sensory Axons

Tal Burstyn-Cohen1, Ayala Frumkin1, Yi-Tian Xu2, Steven S. Scherer2, and Avihu Klar1

1 Department of Anatomy and Cell Biology, The Hebrew University-Hadassah Medical School, Jerusalem, 91120 Israel, and 2 Department of Neurology, The University of Pennsylvania, Philadelphia, Pennsylvania 19104-6077

F-spondin, an extracellular matrix protein, is present in peripheral nerve during embryonic development, but its amount diminishes by birth. Axotomy of adult rat sciatic nerve, however, causes a massive upregulation of both F-spondin mRNA and protein distal to the lesion. F-spondin in the distal stump of axotomized nerve promotes neurite outgrowth of sensory neurons, as revealed by protein neutralization with F-spondin-specific antibodies. Thus, F-spondin is likely to play a role in promoting axonal regeneration after nerve injury.

Key words: nerve regeneration; neurite outgrowth; Schwann cells; extracellular matrix; F-spondin; sensory axons

Copyright © 1998 Society for Neuroscience  0270-6474/98/18218875-11$05.00/0


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