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The Journal of Neuroscience, November 1, 1998, 18(21):8990-9001

Odorant-Induced and Sniff-Induced Activation in the Cerebellum of the Human

Noam Sobel¹, Vivek Prabhakaran¹, Catherine A. Hartley², John E. Desmond³, Zuo Zhao³, Gary H. Glover⁴, John D.E. Gabrieli^{1, 3}, and Edith V. Sullivan^{1, 5}

Programs in ¹ Neuroscience and ² Symbolic Systems, and Departments of ³ Psychology, ⁴ Radiology, and ⁵ Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, 94305

Functional magnetic resonance imaging was used to test whether odorants induce activation in the cerebellum of the human. The odorants vanillin and propionic acid both induced significant activation, primarily in the posterior lateral hemispheres. Activation was concentration-dependent, greater after stimulation with higher concentration odorants. By contrast, the action of sniffing nonodorized air induced significant activation in the anterior cerebellum, primarily in the central lobule. These findings demonstrate that the cerebellum plays a role in human olfaction. A hypothesis is proposed whereby the cerebellum maintains a feedback mechanism that regulates sniff volume in relation to odor concentration.

Key words: olfaction; cerebellum; sniffing; odor; smell; human

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Copyright © 1998 Society for Neuroscience  0270-6474/98/18218990-12$05.00/0

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