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The Journal of Neuroscience, November 15, 1998, 18(22):9256-9268
Slow Oscillations ( 1 Hz) Mediated by GABAergic Interneuronal
Networks in Rat Hippocampus
Y.
Zhang1,
J. L.
Perez Velazquez1, 5,
G. F.
Tian3,
C.-P.
Wu1, 5,
F. K.
Skinner1, 2, 3, 4,
P. L.
Carlen1, 2, 3, 5, and
L.
Zhang1, 2, 5
1 Playfair Neuroscience Unit, Toronto Hospital Research
Institute, Departments of 2 Medicine (Neurology) and
3 Physiology, 4 Institute of Biomedical
Engineering, 5 Bloorview Epilepsy Research Program,
University of Toronto, Toronto, Ontario, Canada M5T 2S8
Perfusion of rat brain slices with low millimole CsCl elicits slow
oscillations of  1 Hz in hippocampal CA1 pyramidal neurons. These
oscillations are GABAA receptor-mediated hyperpolarizations that permit a coherent fire-pause pattern in a population of CA1 neurons. They can persist without the activation of ionotropic glutamate receptors but require adenosine-dependent inhibition of
glutamate transmission. In response to external Cs+,
multiple interneurons in the CA1 region display rhythmic discharges that correlate with the slow oscillations in CA1 pyramidal neurons. The
interneuronal discharges arise spontaneously from the resting potential, and their rhythmicity is regulated by periodic,
GABAA receptor-mediated hyperpolarizations. In addition,
interneurons show periodic partial spikes and neurobiotin coupling, and
applications of known gap junctional uncouplers interrupt the
Cs+-induced slow rhythm in both CA1 pyramidal
neurons and interneurons. We propose that these slow oscillations
originate from a GABAergic interneuronal network that interacts through
reciprocal inhibition and possibly gap junctional connection.
Key words:
adenosine; brain slices; GABA; gap junctions; interneurons; oscillations
Copyright © 1998 Society for Neuroscience 0270-6474/98/18229256-13$05.00/0
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