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The Journal of Neuroscience, November 15, 1998, 18(22):9335-9341

Persyn, a Member of the Synuclein Family, Has a Distinct Pattern of Expression in the Developing Nervous System

Vladimir L. Buchman¹, Hamish J. A. Hunter¹, Luzia G. P. Pinõn¹, Jane Thompson¹, Eugenia M. Privalova^{1, 2}, Natalia N. Ninkina^{1, 2}, and Alun M. Davies^{1, 3}

¹ School of Biomedical Sciences, University of St. Andrews, Bute Medical Buildings, St. Andrews, Fife KY16 9AJ, Scotland, United Kingdom, ² Institute of Gene Biology, Russian Academy of Sciences, Moscow B-334, Russia, and ³ Neuropa Limited, Robertson Building, Dumbarton Road, Glasgow G11 6NU, Scotland, United Kingdom

The synucleins are a unique family of small intracellular proteins that have recently attracted considerable attention because of their involvement in human neurodegenerative diseases. We have cloned a new member of the synuclein family called persyn. In contrast to other synucleins, which are presynaptic proteins of CNS neurons, persyn is a cytosolic protein that is expressed predominantly in the cell bodies and axons of primary sensory neurons, sympathetic neurons, and motoneurons. Northern blotting, in situ hybridization, Western blotting, and immunohistochemistry revealed that persyn mRNA and protein are expressed in these neurons from the earliest stages of axonal outgrowth and are maintained at a high level throughout life. Persyn also becomes detectable in evolutionary recent regions of the brain by adulthood.

Key words: synucleins; neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; development of the nervous system; BCSG1; motoneurons; sensory neurons

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Copyright © 1998 Society for Neuroscience  0270-6474/98/18229335-07$05.00/0

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