 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, December 1, 1998, 18(23):9858-9869
Evidence for the Participation of the Neuron-Specific CDK5 Activator P35 during Laminin-Enhanced Axonal Growth
Gabriela Paglini1, Gustavo Pigino1, Patricia Kunda1, Gerardo Morfini1, Ricardo Maccioni2, Santiago Quiroga3, Adriana Ferreira4, and Alfredo Cáceres1 1 Instituto Mercedes y Martín Ferreyra, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 5000 Cordoba, Argentina, 2 Laboratorio Biología Celular y Molecular, Universidad de Chile, 5000 Santiago, Chile, 3 Departamento Quimica Biologica, CONICET, Universidad Nacional de Cordoba, 5000 Cordoba, Argentina, and 4 Institute of Neuroscience and Department of Cell and Molecular Biology, Northwestern University, Chicago, Illinois 60611
Cultures of cerebellar macroneurons were used to study the pattern of expression, subcellular localization, and function of the neuronal cdk5 activator p35 during laminin-enhanced axonal growth. The results obtained indicate that laminin, an extracellular matrix molecule capable of selectively stimulating axonal extension and promoting MAP1B phosphorylation at a proline-directed protein kinase epitope, selectively stimulates p35 expression, increases its association with the subcortical cytoskeleton, and accelerates its redistribution to the axonal growth cones. Besides, suppression of p35, but not of a highly related isoform designated as p39, by antisense oligonucleotide treatment selectively reduces cdk5 activity, laminin-enhanced axonal elongation, and MAP1b phosphorylation. Taken collectively, the present results suggest that cdk5/p35 may serve as an important regulatory linker between environmental signals (e.g., laminin) and constituents of the intracellular machinery (e.g., MAP1B) involved in axonal elongation.
Key words: cdk5; p35; neurons; development; axon; growth cones; MAP1b; phosphorylation; antisense oligonucleotides; neuronal cultures
Copyright © 1998 Society for Neuroscience 0270-6474/98/18239858-12$05.00/0
This article has been cited by other articles:
T. M. E. Scales, S. Lin, M. Kraus, R. G. Goold, and P. R. Gordon-Weeks
Nonprimed and DYRK1A-primed GSK3{beta}-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons
J. Cell Sci., July 15, 2009; 122(14): 2424 - 2435.
[Abstract] [Full Text] [PDF]
M. Donoso, J. Cancino, J. Lee, P. van Kerkhof, C. Retamal, G. Bu, A. Gonzalez, A. Caceres, and M.-P. Marzolo
Polarized Traffic of LRP1 Involves AP1B and SNX17 Operating on Y-dependent Sorting Motifs in Different Pathways
Mol. Biol. Cell, January 1, 2009; 20(1): 481 - 497.
[Abstract] [Full Text] [PDF]
K.-H. Sun, Y. de Pablo, F. Vincent, E. O. Johnson, A. K. Chavers, and K. Shah
Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease
Mol. Biol. Cell, July 1, 2008; 19(7): 3052 - 3069.
[Abstract] [Full Text] [PDF]
L. He, Z. Hou, and R. Z. Qi
Calmodulin Binding and Cdk5 Phosphorylation of p35 Regulate Its Effect on Microtubules
J. Biol. Chem., May 9, 2008; 283(19): 13252 - 13260.
[Abstract] [Full Text] [PDF]
M. Paveliev, M. Lume, A. Velthut, M. Phillips, U. Arumae, and M. Saarma
Neurotrophic factors switch between two signaling pathways that trigger axonal growth
J. Cell Sci., August 1, 2007; 120(15): 2507 - 2516.
[Abstract] [Full Text] [PDF]
C. Nguyen, A. Nishi, J. W. Kansy, J. Fernandez, K. Hayashi, F. Gillardon, H. C. Hemmings Jr., A. C. Nairn, and J. A. Bibb
Regulation of Protein Phosphatase Inhibitor-1 by Cyclin-dependent Kinase 5
J. Biol. Chem., June 1, 2007; 282(22): 16511 - 16520.
[Abstract] [Full Text] [PDF]
W. Luo, F. Dou, A. Rodina, S. Chip, J. Kim, Q. Zhao, K. Moulick, J. Aguirre, N. Wu, P. Greengard, et al.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies
PNAS, May 29, 2007; 104(22): 9511 - 9516.
[Abstract] [Full Text] [PDF]
Y. Horiuchi, A. Asada, S.-i. Hisanaga, A. Toh-e, and M. Nishizawa
Identifying novel substrates for mouse Cdk5 kinase using the yeast Saccharomyces cerevisiae
Genes Cells, December 1, 2006; 11(12): 1393 - 1404.
[Abstract] [Full Text] [PDF]
A. R. Cole, F. Causeret, G. Yadirgi, C. J. Hastie, H. McLauchlan, E. J. McManus, F. Hernandez, B. J. Eickholt, M. Nikolic, and C. Sutherland
Distinct Priming Kinases Contribute to Differential Regulation of Collapsin Response Mediator Proteins by Glycogen Synthase Kinase-3 in Vivo
J. Biol. Chem., June 16, 2006; 281(24): 16591 - 16598.
[Abstract] [Full Text] [PDF]
S. Cicero and K. Herrup
Cyclin-Dependent Kinase 5 Is Essential for Neuronal Cell Cycle Arrest and Differentiation
J. Neurosci., October 19, 2005; 25(42): 9658 - 9668.
[Abstract] [Full Text] [PDF]
C. Gonzalez-Billault, J. A. Del Rio, J. M. Urena, E. M. Jimenez-Mateos, M. J. Barallobre, M. Pascual, L. Pujadas, S. Simo, A. L. Torre, R. Gavin, et al.
A role of MAP1B in Reelin-dependent Neuronal Migration
Cereb Cortex, August 1, 2005; 15(8): 1134 - 1145.
[Abstract] [Full Text] [PDF]
L. Lilja, J. U. Johansson, J. Gromada, S. A. Mandic, G. Fried, P.-O. Berggren, and C. Bark
Cyclin-dependent Kinase 5 Associated with p39 Promotes Munc18-1 Phosphorylation and Ca2+-dependent Exocytosis
J. Biol. Chem., July 9, 2004; 279(28): 29534 - 29541.
[Abstract] [Full Text] [PDF]
M. Ubeda, D. M. Kemp, and J. F. Habener
Glucose-Induced Expression of the Cyclin-Dependent Protein Kinase 5 Activator p35 Involved in Alzheimer's Disease Regulates Insulin Gene Transcription in Pancreatic {beta}-Cells
Endocrinology, June 1, 2004; 145(6): 3023 - 3031.
[Abstract] [Full Text] [PDF]
J. L. Rosales, B.-C. Lee, M. Modarressi, K. P. Sarker, K.-Y. Lee, Y.-G. Jeong, R. Oko, and K.-Y. Lee
Outer Dense Fibers Serve as a Functional Target for Cdk5{middle dot}p35 in the Developing Sperm Tail
J. Biol. Chem., January 9, 2004; 279(2): 1224 - 1232.
[Abstract] [Full Text] [PDF]
J. L. Hallows, K. Chen, R. A. DePinho, and I. Vincent
Decreased Cyclin-Dependent Kinase 5 (cdk5) Activity Is Accompanied by Redistribution of cdk5 and Cytoskeletal Proteins and Increased Cytoskeletal Protein Phosphorylation in p35 Null Mice
J. Neurosci., November 19, 2003; 23(33): 10633 - 10644.
[Abstract] [Full Text] [PDF]
S. Kesavapany, K.-F. Lau, S. Ackerley, S. J. Banner, S. J. A. Shemilt, J. D. Cooper, P. N. Leigh, C. E. Shaw, D. M. McLoughlin, and C. C. J. Miller
Identification of a Novel, Membrane-Associated Neuronal Kinase, Cyclin-Dependent Kinase 5/p35-Regulated Kinase
J. Neurosci., June 15, 2003; 23(12): 4975 - 4983.
[Abstract] [Full Text] [PDF]
R. Borghi, L. Giliberto, A. Assini, A. Delacourte, G. Perry, M. A. Smith, P. Strocchi, D. Zaccheo, and M. Tabaton
Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy
Neurology, February 26, 2002; 58(4): 589 - 592.
[Abstract] [Full Text] [PDF]
S. Ross, A. Tienhaara, M.-S. Lee, L.-H. Tsai, and G. Gill
GC Box-binding Transcription Factors Control the Neuronal Specific Transcription of the Cyclin-dependent Kinase 5 Regulator p35
J. Biol. Chem., February 1, 2002; 277(6): 4455 - 4464.
[Abstract] [Full Text] [PDF]
E. C. Gilmore and K. Herrup
Neocortical Cell Migration: GABAergic Neurons and Cells in Layers I and VI Move in a Cyclin-Dependent Kinase 5-Independent Manner
J. Neurosci., December 15, 2001; 21(24): 9690 - 9700.
[Abstract] [Full Text] [PDF]
J. Teng, Y. Takei, A. Harada, T. Nakata, J. Chen, and N. Hirokawa
Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization
J. Cell Biol., October 1, 2001; 155(1): 65 - 76.
[Abstract] [Full Text] [PDF]
J. Ko, S. Humbert, R. T. Bronson, S. Takahashi, A. B. Kulkarni, E. Li, and L.-H. Tsai
p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment
J. Neurosci., September 1, 2001; 21(17): 6758 - 6771.
[Abstract] [Full Text] [PDF]
C. Gonzalez-Billault, J. Avila, and A. Caceres
Evidence for the Role of MAP1B in Axon Formation
Mol. Biol. Cell, July 1, 2001; 12(7): 2087 - 2098.
[Abstract] [Full Text] [PDF]
D. S. Smith, P. L. Greer, and L.-H. Tsai
Cdk5 on the Brain
Cell Growth Differ., June 1, 2001; 12(6): 277 - 283.
[Abstract] [Full Text] [PDF]
A. Catania, S. Urban, E. Yan, C. Hao, G. Barron, and J. Allalunis-Turner
Expression and localization of cyclin-dependent kinase 5 in apoptotic human glioma cells
Neuro-oncol, April 1, 2001; 3(2): 89 - 98.
[Abstract] [PDF]
P. Kunda, G. Paglini, S. Quiroga, K. Kosik, and A. Caceres
Evidence for the Involvement of Tiam1 in Axon Formation
J. Neurosci., April 1, 2001; 21(7): 2361 - 2372.
[Abstract] [Full Text] [PDF]
T. Tanaka, Veeranna, T. Ohshima, P. Rajan, N. D. Amin, A. Cho, T. Sreenath, H. C. Pant, R. O. Brady, and A. B. Kulkarni
Neuronal Cyclin-Dependent Kinase 5 Activity Is Critical for Survival
J. Neurosci., January 15, 2001; 21(2): 550 - 558.
[Abstract] [Full Text] [PDF]
J. Chen, Y. Zhang, M. B. Kelz, C. Steffen, E. S. Ang, L. Zeng, and E. J. Nestler
Induction of Cyclin-Dependent Kinase 5 in the Hippocampus by Chronic Electroconvulsive Seizures: Role of {Delta}FosB
J. Neurosci., December 15, 2000; 20(24): 8965 - 8971.
[Abstract] [Full Text] [PDF]
A. Meixner, S. Haverkamp, H. Wassle, S. Fuhrer, J. Thalhammer, N. Kropf, R. E. Bittner, H. Lassmann, G. Wiche, and F. Propst
Map1b Is Required for Axon Guidance and Is Involved in the Development of the Central and Peripheral Nervous System
J. Cell Biol., December 11, 2000; 151(6): 1169 - 1178.
[Abstract] [Full Text] [PDF]
B.-S. Li, L. Zhang, J. Gu, N. D. Amin, and H. C. Pant
Integrin alpha 1beta 1-Mediated Activation of Cyclin-Dependent Kinase 5 Activity Is Involved in Neurite Outgrowth and Human Neurofilament Protein H Lys-Ser-Pro Tail Domain Phosphorylation
J. Neurosci., August 15, 2000; 20(16): 6055 - 6062.
[Abstract] [Full Text] [PDF]
S Humbert, R Dhavan, and L Tsai
p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton
J. Cell Sci., January 3, 2000; 113(6): 975 - 983.
[Abstract] [PDF]
D. Huang, G. Patrick, J. Moffat, L.-H. Tsai, and B. Andrews
Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase
PNAS, December 7, 1999; 96(25): 14445 - 14450.
[Abstract] [Full Text] [PDF]
F. Aboitiz
Feature Article: Evolution of Isocortical Organization. A Tentative Scenario Including Roles of Reelin, p35/cdk5 and the Subplate Zone
Cereb Cortex, October 1, 1999; 9(7): 655 - 661.
[Abstract] [Full Text] [PDF]
X. Wang, Y.-P. Ching, W.-H. Lam, Z. Qi, M. Zhang, and J. H. Wang
Identification of a Common Protein Association Region in the Neuronal Cdk5 Activator
J. Biol. Chem., October 6, 2000; 275(41): 31763 - 31769.
[Abstract] [Full Text] [PDF]
T. Rashid, M. Banerjee, and M. Nikolic
Phosphorylation of Pak1 by the p35/Cdk5 Kinase Affects Neuronal Morphology
J. Biol. Chem., December 21, 2001; 276(52): 49043 - 49052.
[Abstract] [Full Text] [PDF]
G.-i. Kusakawa, T. Saito, R. Onuki, K. Ishiguro, T. Kishimoto, and S.-i. Hisanaga
Calpain-dependent Proteolytic Cleavage of the p35 Cyclin-dependent Kinase 5 Activator to p25
J. Biol. Chem., May 26, 2000; 275(22): 17166 - 17172.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|