 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, December 1, 1998, 18(23):9870-9895
Correlation-Based Development of Ocularly Matched Orientation and Ocular Dominance Maps: Determination of Required Input Activities
Ed Erwin1, 4 and Kenneth D. Miller1, 2, 3, 4, 5 Departments of 1 Physiology and 2 Otolaryngology, 3 Neuroscience Graduate Program, 4 W. M. Keck Center for Integrative Neuroscience, and 5 Sloan Center for Theoretical Neurobiology, University of California, San Francisco, California 94143-0444
We extend previous models for separate development of ocular dominance and orientation selectivity in cortical layer 4 by exploring conditions permitting combined organization of both properties. These conditions are expressed in terms of functions describing the degree of correlation in the firing of two inputs from the lateral geniculate nucleus (LGN), as a function of their retinotopic separation and their "type" (ON center or OFF center and left eye or right eye).
The development of ocular dominance requires that the correlations of an input with other inputs of the same eye be stronger than or equal to its correlations with inputs of the opposite eye and strictly stronger at small retinotopic separations. This must be true after summing correlations with inputs of both center types. The development of orientation-selective simple cells requires that (1) an input's correlations with other inputs of the same center type be stronger than its correlations with inputs of the opposite center type at small retinotopic separation; and (2) this relationship reverse at larger retinotopic separations within an arbor radius (the radius over which LGN cells can project to a common cortical point). This must be true after summing correlations with inputs serving both eyes.
For orientations to become matched in the two eyes, correlated activity within the receptive fields must be maximized by specific between-eye alignments of ON and OFF subregions. Thus the correlations between the eyes must differ depending on center type, and this difference must vary with retinotopic separation within an arbor radius.
These principles are satisfied by a wide class of correlation functions. Combined development of ocularly matched orientation maps and ocular dominance maps can be achieved either simultaneously or sequentially. In the latter case, the model can produce a correlation between the locations of orientation map singularities and local ocular dominance peaks similar to that observed physiologically.
The model's main prediction is that the above correlations should exist among inputs to cortical layer 4 simple cells before vision. In addition, mature simple cells are predicted to have certain relationships between the locations of the ON and OFF subregions of the left and right eyes' receptive fields.
Key words: Hebb synapse; visual cortex; striate cortex; simple cell; binocular cell; model
Copyright © 1998 Society for Neuroscience 0270-6474/98/18239870-26$05.00/0
This article has been cited by other articles:
M. A. Carreira-Perpinan and G. J. Goodhill
Influence of Lateral Connections on the Structure of Cortical Maps
J Neurophysiol, November 1, 2004; 92(5): 2947 - 2959.
[Abstract] [Full Text] [PDF]
D. L. Ringach
Haphazard Wiring of Simple Receptive Fields and Orientation Columns in Visual Cortex
J Neurophysiol, July 1, 2004; 92(1): 468 - 476.
[Abstract] [Full Text] [PDF]
M. Fagiolini, H. Katagiri, H. Miyamoto, H. Mori, S. G. N. Grant, M. Mishina, and T. K. Hensch
Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling
PNAS, March 4, 2003; 100(5): 2854 - 2859.
[Abstract] [Full Text] [PDF]
W. M. Usrey, M. P. Sceniak, and B. Chapman
Receptive Fields and Response Properties of Neurons in Layer 4 of Ferret Visual Cortex
J Neurophysiol, February 1, 2003; 89(2): 1003 - 1015.
[Abstract] [Full Text] [PDF]
T. R. Candy, A. M. Skoczenski, and A. M. Norcia
Normalization Models Applied to Orientation Masking in the Human Infant
J. Neurosci., June 15, 2001; 21(12): 4530 - 4541.
[Abstract] [Full Text] [PDF]
J. C. Crowley and L. C. Katz
Early Development of Ocular Dominance Columns
Science, November 17, 2000; 290(5495): 1321 - 1324.
[Abstract] [Full Text]
A. B. Lee, B. Blais, H. Z. Shouval, and L. N Cooper
Statistics of lateral geniculate nucleus (LGN) activity determine the segregation of ON/OFF subfields for simple cells in visual cortex
PNAS, November 7, 2000; 97(23): 12875 - 12879.
[Abstract] [Full Text] [PDF]
B. Chapman and I. Godecke
Cortical Cell Orientation Selectivity Fails to Develop in the Absence of ON-Center Retinal Ganglion Cell Activity
J. Neurosci., March 1, 2000; 20(5): 1922 - 1930.
[Abstract] [Full Text] [PDF]
H. Z. Shouval, D. H. Goldberg, J. P. Jones, M. Beckerman, and L. N. Cooper
Structured Long-Range Connections Can Provide a Scaffold for Orientation Maps
J. Neurosci., February 1, 2000; 20(3): 1119 - 1128.
[Abstract] [Full Text] [PDF]
W. M. Usrey, J. B. Reppas, and R. C. Reid
Specificity and Strength of Retinogeniculate Connections
J Neurophysiol, December 1, 1999; 82(6): 3527 - 3540.
[Abstract] [Full Text] [PDF]
L. E. White, W. H. Bosking, S. M. Williams, and D. Fitzpatrick
Maps of Central Visual Space in Ferret V1 and V2 Lack Matching Inputs from the Two Eyes
J. Neurosci., August 15, 1999; 19(16): 7089 - 7099.
[Abstract] [Full Text] [PDF]
E. Erwin and K. D. Miller
The Subregion Correspondence Model of Binocular Simple Cells
J. Neurosci., August 15, 1999; 19(16): 7212 - 7229.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|