QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (27) Citing Articles via Google Scholar Google Scholar Articles by Polleux, F. Articles by Kennedy, H. Search for Related Content PubMed PubMed Citation Articles by Polleux, F. Articles by Kennedy, H. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Compound via MeSH Substance via MeSH Hazardous Substances DB TRITIUM

 Previous Article  |  Next Article 

The Journal of Neuroscience, December 1, 1998, 18(23):9910-9923

Neurogenesis and Commitment of Corticospinal Neurons in reeler

Franck Polleux, Colette Dehay, and Henry Kennedy

Institut National de la Santé et de la Recherche Médicale U371-Cerveau et Vision, 69675 Bron Cedex, France

In the homozygous (but not the heterozygous) reeler mutant, disruption of neuron migration leads to a major perturbation of the cortical environment that in turn could modify (1) the specification of neuronal fate and (2) the proliferation dynamics of cortical precursors. To investigate these issues, tritiated thymidine injections during cortical neurogenesis were coupled with postnatal injections of a retrograde tracer in the spinal cord to accurately measure the neurogenesis of corticospinal neurons in the heterozygous and homozygous mutant. The homozygous reeler shows (1) strict conservation of area-specific timetables of corticospinal neuron generation; (2) neurons with the appropriate birthdates show an enhanced probability of projecting to the spinal cord; (3) during early stages of corticogenesis, there is a reduced rate of neuron production followed at later stages by an increased rate of neuron production; and (4) these changes in the rate of neuron production were shown to be at least partially attributable to changes in the proportions of differentiative divisions. Taken together, our results show that in the developing cortex, the neurogenesis and specification of a given neuronal phenotype are partially controlled by the postmigratory compartment. On the other hand, neither areal identity nor the chronology of production of layer-specific neuronal phenotype seems to depend on the integrity of the cellular environment.

Key words: corticogenesis; mouse; somatosensory cortex; development; proliferation; tritiated thymidine

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/18239910-14$05.00/0

This article has been cited by other articles:

				N. Ichinohe, A. Knight, M. Ogawa, T. Ohshima, K. Mikoshiba, Y. Yoshihara, T. Terashima, and K. S. Rockland Unusual Patch-Matrix Organization in the Retrosplenial Cortex of the reeler Mouse and Shaking Rat Kawasaki Cereb Cortex, May 1, 2008; 18(5): 1125 - 1138. [Abstract] [Full Text] [PDF]

				H. Fukumitsu, M. Ohtsuka, R. Murai, H. Nakamura, K. Itoh, and S. Furukawa Brain-Derived Neurotrophic Factor Participates in Determination of Neuronal Laminar Fate in the Developing Mouse Cerebral Cortex J. Neurosci., December 20, 2006; 26(51): 13218 - 13230. [Abstract] [Full Text] [PDF]

				V. Hammond, E. So, J. Gunnersen, H. Valcanis, M. Kalloniatis, and S.-S. Tan Layer Positioning of Late-Born Cortical Interneurons Is Dependent on Reelin But Not p35 Signaling J. Neurosci., February 1, 2006; 26(5): 1646 - 1655. [Abstract] [Full Text] [PDF]

				J.-G. Chen, M.-R. Rasin, K. Y. Kwan, and N. Sestan Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex PNAS, December 6, 2005; 102(49): 17792 - 17797. [Abstract] [Full Text] [PDF]

				M. Gotz and L. Sommer Cortical development: the art of generating cell diversity Development, August 1, 2005; 132(15): 3327 - 3332. [Abstract] [Full Text] [PDF]

				C. Zimmer, M.-C. Tiveron, R. Bodmer, and H. Cremer Dynamics of Cux2 Expression Suggests that an Early Pool of SVZ Precursors is Fated to Become Upper Cortical Layer Neurons Cereb Cortex, December 1, 2004; 14(12): 1408 - 1420. [Abstract] [Full Text] [PDF]

				A. Stoykova, O. Hatano, P. Gruss, and M. Gotz Increase in Reelin-positive Cells in the Marginal Zone of Pax6 Mutant Mouse Cortex Cereb Cortex, June 1, 2003; 13(6): 560 - 571. [Abstract] [Full Text] [PDF]

				Z. Molnar, S. Higashi, and G. Lopez-Bendito Choreography of Early Thalamocortical Development Cereb Cortex, June 1, 2003; 13(6): 661 - 669. [Abstract] [Full Text] [PDF]

				F. Polleux, C. Dehay, A. Goffinet, and H. Kennedy Pre- and Post-mitotic Events Contribute to the Progressive Acquisition of Area-specific Connectional Fate in the Neocortex Cereb Cortex, November 1, 2001; 11(11): 1027 - 1039. [Abstract] [Full Text] [PDF]

				C. Dehay, P. Savatier, V. Cortay, and H. Kennedy Cell-Cycle Kinetics of Neocortical Precursors Are Influenced by Embryonic Thalamic Axons J. Neurosci., January 1, 2001; 21(1): 201 - 214. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help