 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, December 15, 1998, 18(24):10345-10355
Modulation of TTX-R INa by PKC and PKA and Their Role in PGE2-Induced Sensitization of Rat Sensory Neurons In Vitro
Michael S. Gold1, Jon D. Levine2, and Ana M. Correa3 1 Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore Dental School, Baltimore, Maryland 21201, 2 Departments of Medicine and Oral Surgery, Division of Neuroscience and National Institutes of Health Pain Center, University of California, San Francisco, California 94143-0440, and 3 Department of Anesthesiology, University of California, Los Angeles, California 90095-1778
A tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa) appears to be the current primarily responsible for action potential generation in the cell body and terminals of nociceptive afferents. Although other voltage-gated Na+ currents are modulated by the activation of protein kinase C (PKC), protein kinase A (PKA), or both, the second messenger pathways involved in the modulation of TTX-R INa are still being defined. We have examined the modulation of TTX-R INa in isolated sensory neurons with whole-cell voltage-clamp recording. Activation of either PKC or PKA increased TTX-R INa. PKA activation also produced a leftward shift in the conductance-voltage relationship of TTX-R INa and an increase in the rates of current activation, deactivation, and inactivation. Inhibitors of PKC decreased TTX-R INa, whereas inhibitors of PKA had no effect on the current. Investigating the interaction between PKC and PKA revealed that although inhibitors of PKA had little effect on PKC-induced modulation of TTX-R INa, inhibitors of PKC significantly attenuated PKA-induced modulation of the current. Finally, although PGE2-induced modulation of TTX-R INa was more similar to PKA-induced modulation of the current than to PKC-induced modulation, PGE2-induced effects were inhibited by inhibitors of both PKC and PKA. Thus, although TTX-R INa is a common target for cellular processes involving the activation of either PKA or PKC, PKC activity is necessary to enable subsequent PKA-mediated modulation of TTX-R INa.
Key words: dorsal root ganglion; inflammatory mediator; nociception; pain; primary afferent; second-messenger
Copyright © 1998 Society for Neuroscience 0270-6474/98/182410345-11$05.00/0
This article has been cited by other articles:
A. Momin, H. Cadiou, A. Mason, and P. A. McNaughton
Role of the hyperpolarization-activated current Ih in somatosensory neurons
J. Physiol., December 15, 2008; 586(24): 5911 - 5929.
[Abstract] [Full Text] [PDF]
M. I. Funez, L. F. Ferrari, D. B. Duarte, D. Sachs, F. Q. Cunha, B. B. Lorenzetti, C. A. Parada, and S. H. Ferreira
Inaugural Article: Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron
PNAS, December 9, 2008; 105(49): 19038 - 19043.
[Abstract] [Full Text] [PDF]
F. Maingret, B. Coste, F. Padilla, N. Clerc, M. Crest, S. M. Korogod, and P. Delmas
Inflammatory Mediators Increase Nav1.9 Current and Excitability in Nociceptors through a Coincident Detection Mechanism
J. Gen. Physiol., February 25, 2008; 131(3): 211 - 225.
[Abstract] [Full Text] [PDF]
J. A. R. Ostman, M. A. Nassar, J. N. Wood, and M. D. Baker
GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9
J. Physiol., February 15, 2008; 586(4): 1077 - 1087.
[Abstract] [Full Text] [PDF]
M. H. Napimoga, G. R. Souza, T. M. Cunha, L. F. Ferrari, J. T. Clemente-Napimoga, C. A. Parada, W. A. Verri Jr., F. Q. Cunha, and S. H. Ferreira
15d-Prostaglandin J2 Inhibits Inflammatory Hypernociception: Involvement of Peripheral Opioid Receptor
J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 313 - 321.
[Abstract] [Full Text] [PDF]
C. Wang, Y. Gu, G.-W. Li, and L.-Y. M. Huang
A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats
J. Physiol., October 1, 2007; 584(1): 191 - 203.
[Abstract] [Full Text] [PDF]
A. Leffler, A. Reiprich, D. P. Mohapatra, and C. Nau
Use-Dependent Block by Lidocaine but Not Amitriptyline Is More Pronounced in Tetrodotoxin (TTX)-Resistant Nav1.8 Than in TTX-Sensitive Na+ Channels
J. Pharmacol. Exp. Ther., January 1, 2007; 320(1): 354 - 364.
[Abstract] [Full Text] [PDF]
F. Amaya, H. Wang, M. Costigan, A. J. Allchorne, J. P. Hatcher, J. Egerton, T. Stean, V. Morisset, D. Grose, M. J. Gunthorpe, et al.
The Voltage-Gated Sodium Channel Nav1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity
J. Neurosci., December 13, 2006; 26(50): 12852 - 12860.
[Abstract] [Full Text] [PDF]
J. H. Sun, B. Yang, D. F. Donnelly, C. Ma, and R. H. LaMotte
MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia
J Neurophysiol, November 1, 2006; 96(5): 2189 - 2199.
[Abstract] [Full Text] [PDF]
C. Ma, K. W. Greenquist, and R. H. LaMotte
Inflammatory Mediators Enhance the Excitability of Chronically Compressed Dorsal Root Ganglion Neurons
J Neurophysiol, April 1, 2006; 95(4): 2098 - 2107.
[Abstract] [Full Text] [PDF]
A. M. Strassman and D. Levy
Response Properties of Dural Nociceptors in Relation to Headache
J Neurophysiol, March 1, 2006; 95(3): 1298 - 1306.
[Abstract] [Full Text] [PDF]
L. Liu, T. M. Yang, W. Liedtke, and S. A. Simon
Chronic IL-1beta Signaling Potentiates Voltage-Dependent Sodium Currents in Trigeminal Nociceptive Neurons
J Neurophysiol, March 1, 2006; 95(3): 1478 - 1490.
[Abstract] [Full Text] [PDF]
M. D Baker
Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones
J. Physiol., September 15, 2005; 567(3): 851 - 867.
[Abstract] [Full Text] [PDF]
H. Wang, T. Kohno, F. Amaya, G. J. Brenner, N. Ito, A. Allchorne, R.-R. Ji, and C. J. Woolf
Bradykinin Produces Pain Hypersensitivity by Potentiating Spinal Cord Glutamatergic Synaptic Transmission
J. Neurosci., August 31, 2005; 25(35): 7986 - 7992.
[Abstract] [Full Text] [PDF]
E. K. Wittmack, A. M. Rush, A. Hudmon, S. G. Waxman, and S. D. Dib-Hajj
Voltage-Gated Sodium Channel Nav1.6 Is Modulated by p38 Mitogen-Activated Protein Kinase
J. Neurosci., July 13, 2005; 25(28): 6621 - 6630.
[Abstract] [Full Text] [PDF]
S. K. Sauer, C. Weidner, R. W. Carr, B. Averbeck, U. Nesnidal, P. W. Reeh, and H. O. Handwerker
Can Receptor Potentials Be Detected With Threshold Tracking in Rat Cutaneous Nociceptive Terminals?
J Neurophysiol, July 1, 2005; 94(1): 219 - 225.
[Abstract] [Full Text] [PDF]
T. B. Hucho, O. A. Dina, and J. D. Levine
Epac Mediates a cAMP-to-PKC Signaling in Inflammatory Pain: An Isolectin B4(+) Neuron-Specific Mechanism
J. Neurosci., June 29, 2005; 25(26): 6119 - 6126.
[Abstract] [Full Text] [PDF]
K. Kwong and L.-Y. Lee
Prostaglandin E2 potentiates a TTX-resistant sodium current in rat capsaicin-sensitive vagal pulmonary sensory neurones
J. Physiol., April 15, 2005; 564(2): 437 - 450.
[Abstract] [Full Text] [PDF]
C. Chen and N. G. Bazan
Endogenous PGE2 Regulates Membrane Excitability and Synaptic Transmission in Hippocampal CA1 Pyramidal Neurons
J Neurophysiol, February 1, 2005; 93(2): 929 - 941.
[Abstract] [Full Text] [PDF]
Y. Chen, A. R. Cantrell, R. O. Messing, T. Scheuer, and W. A. Catterall
Specific Modulation of Na+ Channels in Hippocampal Neurons by Protein Kinase C{epsilon}
J. Neurosci., January 12, 2005; 25(2): 507 - 513.
[Abstract] [Full Text] [PDF]
Y. Ren, X. Zou, L. Fang, and Q. Lin
Sympathetic Modulation of Activity in A{delta}- and C-Primary Nociceptive Afferents After Intradermal Injection of Capsaicin in Rats
J Neurophysiol, January 1, 2005; 93(1): 365 - 377.
[Abstract] [Full Text] [PDF]
G. S. G. Geleoc, J. R. Risner, and J. R. Holt
Developmental Acquisition of Voltage-Dependent Conductances and Sensory Signaling in Hair Cells of the Embryonic Mouse Inner Ear
J. Neurosci., December 8, 2004; 24(49): 11148 - 11159.
[Abstract] [Full Text] [PDF]
H-Y M Cheng and J M Penninger
DREAMing about arthritic pain
Ann Rheum Dis, November 1, 2004; 63(suppl_2): ii72 - ii75.
[Abstract] [Full Text] [PDF]
V. Vellani, O. Zachrisson, and P. A McNaughton
Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF
J. Physiol., October 15, 2004; 560(2): 391 - 401.
[Abstract] [Full Text] [PDF]
R.-R. Ji and G. Strichartz
Cell Signaling and the Genesis of Neuropathic Pain
Sci. Signal., September 28, 2004; 2004(252): re14 - re14.
[Abstract] [Full Text] [PDF]
Z.-Y. Zhuang, H. Xu, D. E. Clapham, and R.-R. Ji
Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory Neurons and Mediates Inflammatory Heat Hyperalgesia through TRPV1 Sensitization
J. Neurosci., September 22, 2004; 24(38): 8300 - 8309.
[Abstract] [Full Text] [PDF]
S. Hong, T. J. Morrow, P. E. Paulson, L. L. Isom, and J. W. Wiley
Early Painful Diabetic Neuropathy Is Associated with Differential Changes in Tetrodotoxin-sensitive and -resistant Sodium Channels in Dorsal Root Ganglion Neurons in the Rat
J. Biol. Chem., July 9, 2004; 279(28): 29341 - 29350.
[Abstract] [Full Text] [PDF]
S. Amadesi, J. Nie, N. Vergnolle, G. S. Cottrell, E. F. Grady, M. Trevisani, C. Manni, P. Geppetti, J. A. McRoberts, H. Ennes, et al.
Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia
J. Neurosci., May 5, 2004; 24(18): 4300 - 4312.
[Abstract] [Full Text] [PDF]
K. Vijayaragavan, M. Boutjdir, and M. Chahine
Modulation of Nav1.7 and Nav1.8 Peripheral Nerve Sodium Channels by Protein Kinase A and Protein Kinase C
J Neurophysiol, April 1, 2004; 91(4): 1556 - 1569.
[Abstract] [Full Text] [PDF]
C. J. Woolf
Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management
Ann Intern Med, March 16, 2004; 140(6): 441 - 451.
[Full Text] [PDF]
D. Sachs, F. Q. Cunha, and S. H. Ferreira
Peripheral analgesic blockade of hypernociception: Activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway
PNAS, March 9, 2004; 101(10): 3680 - 3685.
[Abstract] [Full Text] [PDF]
K.-J. Bar, G. Natura, A. Telleria-Diaz, P. Teschner, R. Vogel, E. Vasquez, H.-G. Schaible, and A. Ebersberger
Changes in the Effect of Spinal Prostaglandin E2 during Inflammation: Prostaglandin E (EP1-EP4) Receptors in Spinal Nociceptive Processing of Input from the Normal or Inflamed Knee Joint
J. Neurosci., January 21, 2004; 24(3): 642 - 651.
[Abstract] [Full Text] [PDF]
N. G. Bazan
Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor
J. Lipid Res., December 1, 2003; 44(12): 2221 - 2233.
[Abstract] [Full Text] [PDF]
M. S. Gold, D. Weinreich, C.-S. Kim, R. Wang, J. Treanor, F. Porreca, and J. Lai
Redistribution of NaV1.8 in Uninjured Axons Enables Neuropathic Pain
J. Neurosci., January 1, 2003; 23(1): 158 - 166.
[Abstract] [Full Text] [PDF]
N. T. Blair and B. P. Bean
Roles of Tetrodotoxin (TTX)-Sensitive Na+ Current, TTX-Resistant Na+ Current, and Ca2+ Current in the Action Potentials of Nociceptive Sensory Neurons
J. Neurosci., December 1, 2002; 22(23): 10277 - 10290.
[Abstract] [Full Text] [PDF]
L. R. Watkins and S. F. Maier
Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States
Physiol Rev, October 1, 2002; 82(4): 981 - 1011.
[Abstract] [Full Text] [PDF]
M. S. Gold, L. Zhang, D. L. Wrigley, and R. J. Traub
Prostaglandin E2 Modulates TTX-R INa in Rat Colonic Sensory Neurons
J Neurophysiol, September 1, 2002; 88(3): 1512 - 1522.
[Abstract] [Full Text] [PDF]
Y. Dai, K. Iwata, T. Fukuoka, E. Kondo, A. Tokunaga, H. Yamanaka, T. Tachibana, Y. Liu, and K. Noguchi
Phosphorylation of Extracellular Signal-Regulated Kinase in Primary Afferent Neurons by Noxious Stimuli and Its Involvement in Peripheral Sensitization
J. Neurosci., September 1, 2002; 22(17): 7737 - 7745.
[Abstract] [Full Text] [PDF]
Z. Zhou, G. Davar, and G. Strichartz
Endothelin-1 (ET-1) Selectively Enhances the Activation Gating of Slowly Inactivating Tetrodotoxin-Resistant Sodium Currents in Rat Sensory Neurons: A Mechanism for the Pain-Inducing Actions of ET-1
J. Neurosci., August 1, 2002; 22(15): 6325 - 6330.
[Abstract] [Full Text] [PDF]
C. Chen, J. C. Magee, and N. G. Bazan
Cyclooxygenase-2 Regulates Prostaglandin E2 Signaling in Hippocampal Long-Term Synaptic Plasticity
J Neurophysiol, June 1, 2002; 87(6): 2851 - 2857.
[Abstract] [Full Text] [PDF]
H. Koda and K. Mizumura
Sensitization to Mechanical Stimulation by Inflammatory Mediators and by Mild Burn in Canine Visceral Nociceptors In Vitro
J Neurophysiol, April 1, 2002; 87(4): 2043 - 2051.
[Abstract] [Full Text] [PDF]
S. L Borgland, M. Connor, R. M Ryan, H. J Ball, and M. J Christie
Prostaglandin E2 inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons
J. Physiol., March 1, 2002; 539(2): 433 - 444.
[Abstract] [Full Text] [PDF]
D Levy and A M Strassman
Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors
J. Physiol., January 15, 2002; 538(2): 483 - 493.
[Abstract] [Full Text] [PDF]
X. Shu and L. M. Mendell
Acute Sensitization by NGF of the Response of Small-Diameter Sensory Neurons to Capsaicin
J Neurophysiol, December 1, 2001; 86(6): 2931 - 2938.
[Abstract] [Full Text] [PDF]
E. Lancaster and D. Weinreich
Sodium currents in vagotomized primary afferent neurones of the rat
J. Physiol., October 15, 2001; 536(2): 445 - 458.
[Abstract] [Full Text] [PDF]
K. O. Aley, A. Martin, T. McMahon, J. Mok, J. D. Levine, and R. O. Messing
Nociceptor Sensitization by Extracellular Signal-Regulated Kinases
J. Neurosci., September 1, 2001; 21(17): 6933 - 6939.
[Abstract] [Full Text] [PDF]
S. C. Benn, M. Costigan, S. Tate, M. Fitzgerald, and C. J. Woolf
Developmental Expression of the TTX-Resistant Voltage-Gated Sodium Channels Nav1.8 (SNS) and Nav1.9 (SNS2) in Primary Sensory Neurons
J. Neurosci., August 15, 2001; 21(16): 6077 - 6085.
[Abstract] [Full Text] [PDF]
L. M. Cardenas, C. G. Cardenas, and R. S. Scroggs
5HT Increases Excitability of Nociceptor-Like Rat Dorsal Root Ganglion Neurons Via cAMP-Coupled TTX-Resistant Na+ Channels
J Neurophysiol, July 1, 2001; 86(1): 241 - 248.
[Abstract] [Full Text] [PDF]
L. Liu, M. Oortgiesen, L. Li, and S. A. Simon
Capsaicin Inhibits Activation of Voltage-Gated Sodium Currents in Capsaicin-Sensitive Trigeminal Ganglion Neurons
J Neurophysiol, February 1, 2001; 85(2): 745 - 758.
[Abstract] [Full Text] [PDF]
M. S. Gold
Tetrodotoxin-resistant Na+ currents and inflammatory hyperalgesia
PNAS, July 6, 1999; 96(14): 7645 - 7649.
[Abstract] [Full Text] [PDF]
C. J. Woolf and M. Costigan
Transcriptional and posttranslational plasticity and the generation of inflammatory pain
PNAS, July 6, 1999; 96(14): 7723 - 7730.
[Abstract] [Full Text] [PDF]
K. O. Aley and J. D. Levine
Role of Protein Kinase A in the Maintenance of Inflammatory Pain
J. Neurosci., March 15, 1999; 19(6): 2181 - 2186.
[Abstract] [Full Text] [PDF]
D Levy and A M Strassman
Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors
J. Physiol., January 15, 2002; 538(2): 483 - 493.
[Abstract] [Full Text] [PDF]
S. L Borgland, M. Connor, R. M Ryan, H. J Ball, and M. J Christie
Prostaglandin E2 inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons
J. Physiol., March 1, 2002; 539(2): 433 - 444.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|