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Previous Article | Next Article
The Journal of Neuroscience, December 15, 1998, 18(24):10438-10444
UNC-55, an Orphan Nuclear Hormone Receptor, Orchestrates Synaptic Specificity among Two Classes of Motor Neurons in Caenorhabditis elegans
H. Mimi Zhou and W. W. Walthall Department of Biology and Center for Neural Communication and Computation, Georgia State University, Atlanta, Georgia 30303
Loss of UNC-55 function in the nematode Caenorhabditis elegans causes one motor neuron class, the ventral D (VD) motor neurons, to adopt the synaptic pattern of another motor neuron class, the dorsal D (DD) motor neurons. Here we show that unc-55 encodes a member of the nuclear hormone receptor gene family that is similar to the vertebrate chicken ovalbumin upstream promoter transcription factors. Although the VD and DD motor neuron classes arise from different lineages at different developmental stages, they share a number of structural and functional features that appear to be the product of identical genetic programs. UNC-55 is expressed in the VD but not the DD motor neurons to modify this genetic program and to create the synaptic pattern that distinguishes the two motor neuron classes from one another.
Key words: synaptic specificity; C. elegans; motor neurons; nuclear hormone receptor; neuromuscular junction; unc-55
Copyright © 1998 Society for Neuroscience 0270-6474/98/182410438-07$05.00/0
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