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The Journal of Neuroscience, December 15, 1998, 18(24):10457-10463
The Chemokine Growth-Regulated Oncogene- Promotes Spinal Cord
Oligodendrocyte Precursor Proliferation
Shenandoah
Robinson1, 2,
Marie
Tani3,
Robert M.
Strieter4,
Richard M.
Ransohoff3, and
Robert H.
Miller2
Departments of 1 Neurosurgery and
2 Neurosciences, School of Medicine, Case Western Reserve
University, Cleveland, Ohio 44106, 3 Departments of
Neurology and Neurosciences, Lerner Research Institute, Cleveland
Clinic Foundation, Cleveland, Ohio 44195, and 4 The
University of Michigan Medical Center, Department of Internal
Medicine, Ann Arbor, Michigan 48109
Chemokines, (chemotactic cytokines) are a family of regulatory
molecules involved in modulating inflammatory responses. Here we
demonstrate that the chemokine growth-regulated oncogene- (GRO-)
is a potent promoter of oligodendrocyte precursor proliferation. The
proliferative response of immature spinal cord oligodendrocyte precursors to their major mitogen, platelet derived growth factor (PDGF), is dramatically enhanced by GRO- present in spinal cord conditioned medium. One source of GRO- is a subset of spinal cord
astrocytes. Cultures of astrocytes contain GRO- mRNA and protein and
secrete biologically active concentrations of GRO-. In postnatal
spinal cord white matter the location of GRO--immunoreactive cells
is developmentally regulated: GRO-+ cells first appear in ventral
and later in dorsal spinal cord white matter. These results suggest
that localized proliferation of oligodendrocytes is mediated by synergy
between PDGF and GRO-.
Key words:
oligodendrocytes; chemokines; GRO-; cell
proliferation; development; spinal cord
Copyright © 1998 Society for Neuroscience 0270-6474/98/182410457-07$05.00/0
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