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The Journal of Neuroscience, December 15, 1998, 18(24):10464-10472
Synaptic Modifications in Cultured Hippocampal Neurons:
Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell
Type
Guo-qiang
Bi and
Mu-ming
Poo
Department of Biology, University of California at San Diego, La
Jolla, California 92093
In cultures of dissociated rat hippocampal neurons, persistent
potentiation and depression of glutamatergic synapses were induced by
correlated spiking of presynaptic and postsynaptic neurons. The
relative timing between the presynaptic and postsynaptic spiking
determined the direction and the extent of synaptic changes. Repetitive
postsynaptic spiking within a time window of 20 msec after presynaptic
activation resulted in long-term potentiation (LTP), whereas
postsynaptic spiking within a window of 20 msec before the repetitive
presynaptic activation led to long-term depression (LTD). Significant
LTP occurred only at synapses with relatively low initial strength,
whereas the extent of LTD did not show obvious dependence on the
initial synaptic strength. Both LTP and LTD depended on the activation
of NMDA receptors and were absent in cases in which the postsynaptic
neurons were GABAergic in nature. Blockade of L-type calcium channels
with nimodipine abolished the induction of LTD and reduced the extent of LTP. These results underscore the importance of precise spike timing, synaptic strength, and postsynaptic cell type in the
activity-induced modification of central synapses and suggest that
Hebb's rule may need to incorporate a quantitative consideration of
spike timing that reflects the narrow and asymmetric window for the induction of synaptic modification.
Key words:
synaptic modification; plasticity; hippocampal neurons; LTP; LTD; correlated-activity; spike timing; spiking; Hebb's rule; Hebbian; target specificity; cell culture
Copyright © 1998 Society for Neuroscience 0270-6474/98/182410464-09$05.00/0
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B. M. Kampa and G. J. Stuart
Calcium spikes in basal dendrites of layer 5 pyramidal neurons during action potential bursts.
J. Neurosci.,
July 12, 2006;
26(28):
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Y. Dan and M.-M. Poo
Spike timing-dependent plasticity: from synapse to perception.
Physiol Rev,
July 1, 2006;
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S. F. Cooke and T. V. P. Bliss
Plasticity in the human central nervous system
Brain,
July 1, 2006;
129(7):
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[Abstract]
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B. M. Kampa, J. J. Letzkus, and G. J. Stuart
Requirement of dendritic calcium spikes for induction of spike-timing-dependent synaptic plasticity
J. Physiol.,
July 1, 2006;
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283 - 290.
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G. M. Wittenberg and S. S.-H. Wang
Malleability of spike-timing-dependent plasticity at the CA3-CA1 synapse.
J. Neurosci.,
June 14, 2006;
26(24):
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P. J. Drew and L. F. Abbott
Extending the effects of spike-timing-dependent plasticity to behavioral timescales
PNAS,
June 6, 2006;
103(23):
8876 - 8881.
[Abstract]
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R. J. Clarke and J. W. Johnson
NMDA Receptor NR2 Subunit Dependence of the Slow Component of Magnesium Unblock
J. Neurosci.,
May 24, 2006;
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R. C. Froemke, I. A. Tsay, M. Raad, J. D. Long, and Y. Dan
Contribution of Individual Spikes in Burst-Induced Long-Term Synaptic Modification
J Neurophysiol,
March 1, 2006;
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Y.-D. Zhou, C. D. Acker, T. I. Netoff, K. Sen, and J. A. White
Increasing Ca2+ transients by broadening postsynaptic action potentials enhances timing-dependent synaptic depression
PNAS,
December 27, 2005;
102(52):
19121 - 19125.
[Abstract]
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E. Fino, J. Glowinski, and L. Venance
Bidirectional Activity-Dependent Plasticity at Corticostriatal Synapses
J. Neurosci.,
December 7, 2005;
25(49):
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R. A. Koene and M. E. Hasselmo
An Integrate-and-fire Model of Prefrontal Cortex Neuronal Activity during Performance of Goal-directed Decision Making
Cereb Cortex,
December 1, 2005;
15(12):
1964 - 1981.
[Abstract]
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B. L. Bloodgood and B. L. Sabatini
Neuronal Activity Regulates Diffusion Across the Neck of Dendritic Spines
Science,
November 4, 2005;
310(5749):
866 - 869.
[Abstract]
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S. D. Faulkner, V. Vorobyov, and F. Sengpiel
Limited Protection of the Primary Visual Cortex from the Effects of Monocular Deprivation by Strabismus
Cereb Cortex,
November 1, 2005;
15(11):
1822 - 1833.
[Abstract]
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D. V. Buonomano
A Learning Rule for the Emergence of Stable Dynamics and Timing in Recurrent Networks
J Neurophysiol,
October 1, 2005;
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F. J Veredas, F. J Vico, and J.-M. Alonso
Factors determining the precision of the correlated firing generated by a monosynaptic connection in the cat visual pathway
J. Physiol.,
September 15, 2005;
567(3):
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D. T. Blake, F. Strata, R. Kempter, and M. M. Merzenich
Experience-Dependent Plasticity in S1 Caused by Noncoincident Inputs
J Neurophysiol,
September 1, 2005;
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S. Ge and J. A. Dani
Nicotinic Acetylcholine Receptors at Glutamate Synapses Facilitate Long-Term Depression or Potentiation
J. Neurosci.,
June 29, 2005;
25(26):
6084 - 6091.
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H. Yao and Y. Dan
Synaptic Learning Rules, Cortical Circuits, and Visual Function
Neuroscientist,
June 1, 2005;
11(3):
206 - 216.
[Abstract]
[PDF]
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J. E. Rubin, R. C. Gerkin, G.-Q. Bi, and C. C. Chow
Calcium Time Course as a Signal for Spike-Timing-Dependent Plasticity
J Neurophysiol,
May 1, 2005;
93(5):
2600 - 2613.
[Abstract]
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J. D. Cohen and M. A. Castro-Alamancos
Skilled Motor Learning Does Not Enhance Long-Term Depression in the Motor Cortex In Vivo
J Neurophysiol,
March 1, 2005;
93(3):
1486 - 1497.
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J. Xu, N. Kang, L. Jiang, M. Nedergaard, and J. Kang
Activity-Dependent Long-Term Potentiation of Intrinsic Excitability in Hippocampal CA1 Pyramidal Neurons
J. Neurosci.,
February 16, 2005;
25(7):
1750 - 1760.
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H. Z. Shouval and G. Kalantzis
Stochastic Properties of Synaptic Transmission Affect the Shape of Spike Time-Dependent Plasticity Curves
J Neurophysiol,
February 1, 2005;
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1069 - 1073.
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A. Starovoytov, J. Choi, and H. S. Seung
Light-Directed Electrical Stimulation of Neurons Cultured on Silicon Wafers
J Neurophysiol,
February 1, 2005;
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1090 - 1098.
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K. Schon, M. E. Hasselmo, M. L. LoPresti, M. D. Tricarico, and C. E. Stern
Persistence of Parahippocampal Representation in the Absence of Stimulus Input Enhances Long-Term Encoding: A Functional Magnetic Resonance Imaging Study of Subsequent Memory after a Delayed Match-to-Sample Task
J. Neurosci.,
December 8, 2004;
24(49):
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S. Fujisawa, N. Matsuki, and Y. Ikegaya
Chronometric readout from a memory trace: gamma-frequency field stimulation recruits timed recurrent activity in the rat CA3 network
J. Physiol.,
November 15, 2004;
561(1):
123 - 131.
[Abstract]
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I. Aradi and G. Maccaferri
Cell Type-Specific Synaptic Dynamics of Synchronized Bursting in the Juvenile CA3 Rat Hippocampus
J. Neurosci.,
October 27, 2004;
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A. K. Lee and M. A. Wilson
A Combinatorial Method for Analyzing Sequential Firing Patterns Involving an Arbitrary Number of Neurons Based on Relative Time Order
J Neurophysiol,
October 1, 2004;
92(4):
2555 - 2573.
[Abstract]
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S. J. Judge and M. E. Hasselmo
Theta Rhythmic Stimulation of Stratum Lacunosum-Moleculare in Rat Hippocampus Contributes to Associative LTP at a Phase Offset in Stratum Radiatum
J Neurophysiol,
September 1, 2004;
92(3):
1615 - 1624.
[Abstract]
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L. M. Frank, G. B. Stanley, and E. N. Brown
Hippocampal Plasticity across Multiple Days of Exposure to Novel Environments
J. Neurosci.,
September 1, 2004;
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[Abstract]
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