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The Journal of Neuroscience, February 1, 1998, 18(3):1096-1104

Spatiotemporal Tuning of Low-Frequency Cells in the Anteroventral Cochlear Nucleus

Laurel H. Carney and Michele Friedman

Department of Biomedical Engineering, Center for Hearing Research, Boston University, Boston, Massachusetts 02215

Low-frequency cells in the anteroventral cochlear nucleus (AVCN) can be sensitive to changes in the spatiotemporal pattern of discharges across their auditory nerve (AN) inputs (). This sensitivity suggests that these cells may be tuned to particular spatiotemporal patterns, or features, in the discharge patterns of populations of AN fibers. To evaluate and characterize this sensitivity, we developed a technique whereby the physiological responses of AVCN cells to wide-band noise were analyzed using the simulated response of a population of AN fibers to the same noise stimulus. By averaging the simulated two-dimensional spatiotemporal pattern of AN activity that preceded each AVCN discharge, it was possible to derive a two-dimensional reverse-correlation function that characterized the spatiotemporal tuning of each AVCN cell. The derived spatiotemporal tuning pattern represented a feature in the AN population response that was most likely to precede discharges of the AVCN cell. To test the spatiotemporal tuning characterizations, we used these patterns to predict the responses of cells to noise stimuli statistically independent from the stimuli used to characterize the cells. This technique provides a general tool for the study of any neural system that involves the analysis of spatiotemporal input patterns.

Key words: spatiotemporal tuning; feature detection; neural encoding; auditory; brainstem; sensory systems

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Copyright © 1998 Society for Neuroscience  0270-6474/98/1831096-09$05.00/0

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