 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, February 1, 1998, 18(3):1115-1123
Modulation of Plasticity in Human Motor Cortex after Forearm Ischemic Nerve Block
Ulf Ziemann, Brian Corwell, and Leonardo G. Cohen Human Cortical Physiology Unit, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
Deafferentation leads to cortical reorganization that may be functionally beneficial or maladaptive. Therefore, we were interested in learning whether it is possible to purposely modulate deafferentation-induced reorganization. Transient forearm deafferentation was induced by ischemic nerve block (INB) in healthy volunteers. The following five interventions were tested: INB alone; INB plus low-frequency (0.1 Hz) repetitive transcranial magnetic stimulation of the motor cortex ipsilateral to INB (INB+rTMSi); rTMSi alone; INB plus rTMS of the motor cortex contralateral to INB (INB+rTMSc); and rTMSc alone. Plastic changes in the motor cortex contralateral to deafferentation were probed with TMS, measuring motor threshold (MT), motor evoked-potential (MEP) size, and intracortical inhibition (ICI) and facilitation (ICF) to the biceps brachii muscle proximal to the level of deafferentation. INB alone induced a moderate increase in MEP size, which was significantly enhanced by INB+rTMSc but blocked by INB+rTMSi. INB alone had no effect on ICI or ICF, whereas INB+rTMSc reduced ICI and increased ICF, and conversely, INB+rTMSi deepened ICI and suppressed ICF. rTMSi and rTMSc alone were ineffective in changing any of these parameters. These findings indicate that the deafferented motor cortex becomes modifiable by inputs that are normally subthreshold for inducing changes in excitability. The deafferentation-induced plastic changes can be up-regulated by direct stimulation of the "plastic" cortex and likely via inhibitory projections down-regulated by stimulation of the opposite cortex. This modulation of cortical plasticity by noninvasive means might be used to facilitate plasticity when it is primarily beneficial or to suppress it when it is predominately maladaptive.
Key words: motor cortical excitability; cortical reorganization; transient forearm deafferentation; ischemic nerve block; human; transcranial magnetic stimulation; modulation of plasticity
Copyright © 1998 Society for Neuroscience 0270-6474/98/1831115-09$05.00/0
This article has been cited by other articles:
T. Fujiwara, Y. Kasashima, K. Honaga, Y. Muraoka, T. Tsuji, R. Osu, K. Hase, Y. Masakado, and M. Liu
Motor Improvement and Corticospinal Modulation Induced by Hybrid Assistive Neuromuscular Dynamic Stimulation (HANDS) Therapy in Patients With Chronic Stroke
Neurorehabil Neural Repair, February 1, 2009; 23(2): 125 - 132.
[Abstract] [PDF]
B. C. Clark, L. C. Issac, J. L. Lane, L. A. Damron, and R. L. Hoffman
Neuromuscular plasticity during and following 3 wk of human forearm cast immobilization
J Appl Physiol, September 1, 2008; 105(3): 868 - 878.
[Abstract] [Full Text] [PDF]
Y.-Z. Huang, J. C. Rothwell, M. J. Edwards, and R.-S. Chen
Effect of Physiological Activity on an NMDA-Dependent Form of Cortical Plasticity in Human
Cereb Cortex, March 1, 2008; 18(3): 563 - 570.
[Abstract] [Full Text] [PDF]
J. Reis, O. B. Swayne, Y. Vandermeeren, M. Camus, M. A. Dimyan, M. Harris-Love, M. A. Perez, P. Ragert, J. C. Rothwell, and L. G. Cohen
Contribution of transcranial magnetic stimulation to the understanding of cortical mechanisms involved in motor control
J. Physiol., January 15, 2008; 586(2): 325 - 351.
[Abstract] [Full Text] [PDF]
O. Hoffken, M. Veit, F. Knossalla, S. Lissek, B. Bliem, P. Ragert, H. R. Dinse, and M. Tegenthoff
Sustained increase of somatosensory cortex excitability by tactile coactivation studied by paired median nerve stimulation in humans correlates with perceptual gain
J. Physiol., October 15, 2007; 584(2): 463 - 471.
[Abstract] [Full Text] [PDF]
N. Mrachacz-Kersting, M. Fong, B. A. Murphy, and T. Sinkjaer
Changes in Excitability of the Cortical Projections to the Human Tibialis Anterior After Paired Associative Stimulation
J Neurophysiol, March 1, 2007; 97(3): 1951 - 1958.
[Abstract] [Full Text] [PDF]
J. P. Lefaucheur, X. Drouot, I. Menard-Lefaucheur, Y. Keravel, and J. P. Nguyen
Motor cortex rTMS restores defective intracortical inhibition in chronic neuropathic pain.
Neurology, November 14, 2006; 67(9): 1568 - 1574.
[Abstract] [Full Text] [PDF]
G. Franchi and C. Veronesi
Short-term reorganization of input-deprived motor vibrissae representation following motor disconnection in adult rats
J. Physiol., July 15, 2006; 574(2): 457 - 476.
[Abstract] [Full Text] [PDF]
U. Ziemann, F. Meintzschel, A. Korchounov, and T. V. Ilic
Pharmacological Modulation of Plasticity in the Human Motor Cortex
Neurorehabil Neural Repair, June 1, 2006; 20(2): 243 - 251.
[Abstract] [PDF]
F. Bretzner and T. Drew
Changes in Corticospinal Efficacy Contribute to the Locomotor Plasticity Observed After Unilateral Cutaneous Denervation of the Hindpaw in the Cat
J Neurophysiol, October 1, 2005; 94(4): 2911 - 2927.
[Abstract] [Full Text] [PDF]
B. Fierro, F. Brighina, G. Vitello, A. Piazza, S. Scalia, G. Giglia, O. Daniele, and A. Pascual-Leone
Modulatory effects of low- and high-frequency repetitive transcranial magnetic stimulation on visual cortex of healthy subjects undergoing light deprivation
J. Physiol., June 1, 2005; 565(2): 659 - 665.
[Abstract] [Full Text] [PDF]
F. Hummel and L. G. Cohen
Improvement of Motor Function with Noninvasive Cortical Stimulation in a Patient with Chronic Stroke
Neurorehabil Neural Repair, March 1, 2005; 19(1): 14 - 19.
[Abstract] [PDF]
F. Hummel, P. Celnik, P. Giraux, A. Floel, W.-H. Wu, C. Gerloff, and L. G. Cohen
Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke
Brain, March 1, 2005; 128(3): 490 - 499.
[Abstract] [Full Text] [PDF]
H. Alkadhi, P. Brugger, S. H. Boendermaker, G. Crelier, A. Curt, M.-C. Hepp-Reymond, and S. S. Kollias
What Disconnection Tells about Motor Imagery: Evidence from Paraplegic Patients
Cereb Cortex, February 1, 2005; 15(2): 131 - 140.
[Abstract] [Full Text] [PDF]
A. Y. On, B. Uludag, E. Taskiran, and C. Ertekin
Differential Corticomotor Control of a Muscle Adjacent to a Painful Joint
Neurorehabil Neural Repair, September 1, 2004; 18(3): 127 - 133.
[Abstract] [PDF]
C. M. Butefisch, V. Khurana, L. Kopylev, and L. G. Cohen
Enhancing Encoding of a Motor Memory in the Primary Motor Cortex By Cortical Stimulation
J Neurophysiol, May 1, 2004; 91(5): 2110 - 2116.
[Abstract] [Full Text] [PDF]
C. M. Butefisch
Plasticity in the Human Cerebral Cortex: Lessons from the Normal Brain and from Stroke
Neuroscientist, April 1, 2004; 10(2): 163 - 173.
[Abstract] [PDF]
H. R. Siebner, N. Lang, V. Rizzo, M. A. Nitsche, W. Paulus, R. N. Lemon, and J. C. Rothwell
Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex
J. Neurosci., March 31, 2004; 24(13): 3379 - 3385.
[Abstract] [Full Text] [PDF]
H. R. Siebner, S. R. Filipovic, J. B. Rowe, C. Cordivari, W. Gerschlager, J. C. Rothwell, R. S. J. Frackowiak, and K. P. Bhatia
Patients with focal arm dystonia have increased sensitivity to slow-frequency repetitive TMS of the dorsal premotor cortex
Brain, December 1, 2003; 126(12): 2710 - 2725.
[Abstract] [Full Text] [PDF]
V. Moliadze, Y. Zhao, U. Eysel, and K. Funke
Effect of transcranial magnetic stimulation on single-unit activity in the cat primary visual cortex
J. Physiol., December 1, 2003; 553(2): 665 - 679.
[Abstract] [Full Text] [PDF]
B. Fierro, R. Ricci, A. Piazza, S. Scalia, G. Giglia, G. Vitello, and F. Brighina
1 Hz rTMS enhances extrastriate cortex activity in migraine: Evidence of a reduced inhibition?
Neurology, November 25, 2003; 61(10): 1446 - 1448.
[Abstract] [Full Text] [PDF]
W. Muellbacher, C. Richards, U. Ziemann, G. Wittenberg, D. Weltz, B. Boroojerdi, L. Cohen, and M. Hallett
Improving Hand Function in Chronic Stroke
Arch Neurol, August 1, 2002; 59(8): 1278 - 1282.
[Abstract] [Full Text] [PDF]
U. Ziemann, G. F. Wittenberg, and L. G. Cohen
Stimulation-Induced Within-Representation and Across-Representation Plasticity in Human Motor Cortex
J. Neurosci., July 1, 2002; 22(13): 5563 - 5571.
[Abstract] [Full Text] [PDF]
K. J. Werhahn, J. Mortensen, A. Kaelin-Lang, B. Boroojerdi, and L. G. Cohen
Cortical excitability changes induced by deafferentation of the contralateral hemisphere
Brain, June 1, 2002; 125(6): 1402 - 1413.
[Abstract] [Full Text] [PDF]
T. Tsuji and J. C Rothwell
Long lasting effects of rTMS and associated peripheral sensory input on MEPs, SEPs and transcortical reflex excitability in humans
J. Physiol., April 1, 2002; 540(1): 367 - 376.
[Abstract] [Full Text] [PDF]
A. Munchau, B. R. Bloem, K. Irlbacher, M. R. Trimble, and J. C. Rothwell
Functional Connectivity of Human Premotor and Motor Cortex Explored with Repetitive Transcranial Magnetic Stimulation
J. Neurosci., January 15, 2002; 22(2): 554 - 561.
[Abstract] [Full Text] [PDF]
P A McNulty, V G Macefield, J L Taylor, and M Hallett
Cortically evoked neural volleys to the human hand are increased during ischaemic block of the forearm
J. Physiol., January 1, 2002; 538(1): 279 - 288.
[Abstract] [Full Text] [PDF]
M C Ridding and J L Taylor
Mechanisms of motor-evoked potential facilitation following prolonged dual peripheral and central stimulation in humans
J. Physiol., December 1, 2001; 537(2): 623 - 631.
[Abstract] [Full Text] [PDF]
M. A. Nitsche and W. Paulus
Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
Neurology, November 27, 2001; 57(10): 1899 - 1901.
[Abstract] [Full Text] [PDF]
W. Gerschlager, H. R. Siebner, and J. C. Rothwell
Decreased corticospinal excitability after subthreshold 1 Hz rTMS over lateral premotor cortex
Neurology, August 14, 2001; 57(3): 449 - 455.
[Abstract] [Full Text] [PDF]
J.-M. Aimonetti and J. B. Nielsen
Changes in intracortical excitability induced by stimulation of wrist afferents in man
J. Physiol., August 1, 2001; 534(3): 891 - 902.
[Abstract] [Full Text] [PDF]
A. Karl, N. Birbaumer, W. Lutzenberger, L. G. Cohen, and H. Flor
Reorganization of Motor and Somatosensory Cortex in Upper Extremity Amputees with Phantom Limb Pain
J. Neurosci., May 15, 2001; 21(10): 3609 - 3618.
[Abstract] [Full Text] [PDF]
T. D Sanger, R. R Garg, and R. Chen
Interactions between two different inhibitory systems in the human motor cortex
J. Physiol., January 15, 2001; 530(2): 307 - 317.
[Abstract] [Full Text] [PDF]
M Oliveri, C Caltagirone, M M Filippi, R Traversa, P Cicinelli, P Pasqualetti, and P M Rossini
Paired transcranial magnetic stimulation protocols reveal a pattern of inhibition and facilitation in the human parietal cortex
J. Physiol., December 1, 2000; 529(2): 461 - 468.
[Abstract] [Full Text] [PDF]
M A Nitsche and W Paulus
Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation
J. Physiol., September 15, 2000; 527(3): 633 - 639.
[Abstract] [Full Text] [PDF]
K. Stefan, E. Kunesch, L. G. Cohen, R. Benecke, and J. Classen
Induction of plasticity in the human motor cortex by paired associative stimulation
Brain, March 1, 2000; 123(3): 572 - 584.
[Abstract] [Full Text] [PDF]
M. Hallett
{blacksquare} REVIEW : Plasticity in the Human Motor System
Neuroscientist, September 1, 1999; 5(5): 324 - 332.
[Abstract] [PDF]
M. S. George, S. H. Lisanby, and H. A. Sackeim
Transcranial Magnetic Stimulation: Applications in Neuropsychiatry
Arch Gen Psychiatry, April 1, 1999; 56(4): 300 - 311.
[Abstract] [Full Text] [PDF]
H. R. Siebner, J. M. Tormos, A. O. C. Baumann, C. Auer, M. D. Catala, B. Conrad, and A. Pascual-Leone
Low-frequency repetitive transcranial magnetic stimulation of the motor cortex in writer's cramp
Neurology, February 1, 1999; 52(3): 529 - 529.
[Abstract] [Full Text] [PDF]
S. Hamdy, J. C. Rothwell, C. Fraser, M. Power, D. Gow, and D. G. Thompson
Patterns of excitability in human esophageal sensorimotor cortex to painful and nonpainful visceral stimulation
Am J Physiol Gastrointest Liver Physiol, February 1, 2002; 282(2): G332 - G337.
[Abstract] [Full Text] [PDF]
P A McNulty, V G Macefield, J L Taylor, and M Hallett
Cortically evoked neural volleys to the human hand are increased during ischaemic block of the forearm
J. Physiol., January 1, 2002; 538(1): 279 - 288.
[Abstract] [Full Text] [PDF]
T. Tsuji and J. C Rothwell
Long lasting effects of rTMS and associated peripheral sensory input on MEPs, SEPs and transcortical reflex excitability in humans
J. Physiol., April 1, 2002; 540(1): 367 - 376.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|