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Previous Article | Next Article
The Journal of Neuroscience, February 15, 1998, 18(4):1305-1317
The Synaptic Basis of GABAA,slow
Matthew I. Banks1, Tong-Bin Li2 and Robert A. Pearce1, 2, 3 Departments of 1 Anesthesiology and 2 Anatomy, and 3 Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706
Although two kinetically distinct evoked GABAA responses (GABAA,fast and GABAA,slow) have been observed in CA1 pyramidal neurons, studies of spontaneous IPSCs (sIPSCs) in these neurons have reported only a single population of events that resemble GABAA,fast in their rise and decay kinetics. The absence of slow sIPSCs calls into question the synaptic basis of GABAA,slow. We present evidence here that both evoked responses are synaptic in origin, because two classes of minimally evoked, spontaneous and miniature IPSCs exist that correspond to GABAA,fast and GABAA,slow. Slow sIPSCs occur infrequently, suggesting that the cells underlying these events have a low spontaneous firing rate, unlike the cells giving rise to fast sIPSCs. Like evoked GABAA,fast and GABAA,slow, fast and slow sIPSCs are modulated differentially by furosemide, a subtype-specific GABAA antagonist. Furosemide blocks fast IPSCs by acting directly on the postsynaptic receptors, because it reduces the amplitude of both miniature IPSCs and the responses of excised patches to applied GABA. Thus, in the hippocampus, parallel inhibitory circuits are composed of separate populations of interneurons that contact anatomically segregated and pharmacologically distinct postsynaptic receptors.
Key words: hippocampus; GABAA receptors; furosemide; IPSC; voltage clamp; pyramidal cell
Copyright © 1998 Society for Neuroscience 0270-6474/98/1841305-13$05.00/0
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