 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, February 15, 1998, 18(4):1318-1328
Peripheral Axotomy Induces Long-Term c-Jun Amino-Terminal Kinase-1 Activation and Activator Protein-1 Binding Activity by c-Jun and junD in Adult Rat Dorsal Root Ganglia In Vivo
Anna Marie Kenney1, 2, 3 and Jeffery D. Kocsis1, 2 1 Department of Neurology, 2 Interdepartmental Neuroscience Program, and 3 PVA/EPVA Neuroscience Research Center, Yale University School of Medicine, New Haven, Connecticut 06510
One of the earliest documented molecular events after sciatic nerve injury in adult rats is the rapid, long-term upregulation of the immediate early gene transcription factor c-Jun mRNA and protein in lumbar dorsal root ganglion (DRG) neurons, suggesting that c-Jun may regulate genes that are important both in the early post-injury period and during later peripheral axonal regeneration. However, neither the mechanism through which c-Jun protein is increased nor the level of its post-injury transcriptional activity in axotomized DRGs has been characterized. To determine whether transcriptional activation of c-Jun occurs in response to nerve injury in vivo and is associated with axonal regeneration, we have assayed axotomized adult rat DRGs for evidence of jun kinase activation, c-Jun phosphorylation, and activator protein-1 (AP-1) binding. We report that sciatic nerve transection resulted in chronic activation of c-Jun amino-terminal kinase-1 (JNK) in L4/L5 DRGs concomitant with c-Jun amino-terminal phosphorylation in neurons, and lasting AP-1 binding activity, with both c-Jun and JunD participating in DNA binding complexes. The timing of JNK activation was dependent on the distance of the axotomy site from the DRGs, suggesting the requirement for a retrograde transport-mediated signal. AP-1 binding and c-Jun protein returned to basal levels in DRGs as peripheral regeneration was completed but remained elevated in the case of chronic sprouting, indicating that c-Jun may regulate target genes that are involved in axonal outgrowth.
Key words: AP-1; axotomy; c-Jun; dorsal root ganglion; JNK; phosphorylation; regeneration; sciatic nerve
Copyright © 1998 Society for Neuroscience 0270-6474/98/1841318-11$05.00/0
This article has been cited by other articles:
T. L. Falzone, G. B. Stokin, C. Lillo, E. M. Rodrigues, E. L. Westerman, D. S. Williams, and L. S. B. Goldstein
Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects
J. Neurosci., May 6, 2009; 29(18): 5758 - 5767.
[Abstract] [Full Text] [PDF]
Y. Chen, C. Geis, and C. Sommer
Activation of TRPV1 Contributes to Morphine Tolerance: Involvement of the Mitogen-Activated Protein Kinase Signaling Pathway
J. Neurosci., May 28, 2008; 28(22): 5836 - 5845.
[Abstract] [Full Text] [PDF]
Q. M. Li, C. Tep, T. Y. Yune, X. Z. Zhou, T. Uchida, K. P. Lu, and S. O. Yoon
Opposite Regulation of Oligodendrocyte Apoptosis by JNK3 and Pin1 after Spinal Cord Injury
J. Neurosci., August 1, 2007; 27(31): 8395 - 8404.
[Abstract] [Full Text] [PDF]
M. Stagi, P. Gorlovoy, S. Larionov, K. Takahashi, and H. Neumann
Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway
FASEB J, December 1, 2006; 20(14): 2573 - 2575.
[Abstract] [Full Text] [PDF]
L. Daulhac, C. Mallet, C. Courteix, M. Etienne, E. Duroux, A.-M. Privat, A. Eschalier, and J. Fialip
Diabetes-Induced Mechanical Hyperalgesia Involves Spinal Mitogen-Activated Protein Kinase Activation in Neurons and Microglia via N-Methyl-D-aspartate-Dependent Mechanisms
Mol. Pharmacol., October 1, 2006; 70(4): 1246 - 1254.
[Abstract] [Full Text] [PDF]
F.-Q. Zhou and W. D Snider
Intracellular control of developmental and regenerative axon growth
Phil Trans R Soc B, September 29, 2006; 361(1473): 1575 - 1592.
[Abstract] [Full Text] [PDF]
A. A. Oliva Jr, C. M. Atkins, L. Copenagle, and G. A. Banker
Activated c-Jun N-Terminal Kinase Is Required for Axon Formation.
J. Neurosci., September 13, 2006; 26(37): 9462 - 9470.
[Abstract] [Full Text] [PDF]
Y.-J. Sung, F. Wu, S. Schacher, and R. T. Ambron
Synaptogenesis regulates axotomy-induced activation of c-Jun-activator protein-1 transcription.
J. Neurosci., June 14, 2006; 26(24): 6439 - 6449.
[Abstract] [Full Text] [PDF]
D. C. David, S. Hauptmann, I. Scherping, K. Schuessel, U. Keil, P. Rizzu, R. Ravid, S. Drose, U. Brandt, W. E. Muller, et al.
Proteomic and Functional Analyses Reveal a Mitochondrial Dysfunction in P301L Tau Transgenic Mice
J. Biol. Chem., June 24, 2005; 280(25): 23802 - 23814.
[Abstract] [Full Text] [PDF]
V. Cavalli, P. Kujala, J. Klumperman, and L. S.B. Goldstein
Sunday Driver links axonal transport to damage signaling
J. Cell Biol., February 28, 2005; 168(5): 775 - 787.
[Abstract] [Full Text] [PDF]
K. Obata, H. Yamanaka, K. Kobayashi, Y. Dai, T. Mizushima, H. Katsura, T. Fukuoka, A. Tokunaga, and K. Noguchi
Role of Mitogen-Activated Protein Kinase Activation in Injured and Intact Primary Afferent Neurons for Mechanical and Heat Hypersensitivity after Spinal Nerve Ligation
J. Neurosci., November 10, 2004; 24(45): 10211 - 10222.
[Abstract] [Full Text] [PDF]
B. Bryan, V. Kumar, L. J. Stafford, Y. Cai, G. Wu, and M. Liu
GEFT, A Rho Family Guanine Nucleotide Exchange Factor, Regulates Neurite Outgrowth and Dendritic Spine Formation
J. Biol. Chem., October 29, 2004; 279(44): 45824 - 45832.
[Abstract] [Full Text] [PDF]
R.-R. Ji and G. Strichartz
Cell Signaling and the Genesis of Neuropathic Pain
Sci. Signal., September 28, 2004; 2004(252): re14 - re14.
[Abstract] [Full Text] [PDF]
S. Kins, P. Kurosinski, R. M. Nitsch, and J. Gotz
Activation of the ERK and JNK Signaling Pathways Caused by Neuron-Specific Inhibition of PP2A in Transgenic Mice
Am. J. Pathol., September 1, 2003; 163(3): 833 - 843.
[Abstract] [Full Text] [PDF]
A. Middlemas, J.-D. Delcroix, N. M. Sayers, D. R. Tomlinson, and P. Fernyhough
Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3
Brain, July 1, 2003; 126(7): 1671 - 1682.
[Abstract] [Full Text] [PDF]
K. Obata, H. Yamanaka, Y. Dai, T. Tachibana, T. Fukuoka, A. Tokunaga, H. Yoshikawa, and K. Noguchi
Differential Activation of Extracellular Signal-Regulated Protein Kinase in Primary Afferent Neurons Regulates Brain-Derived Neurotrophic Factor Expression after Peripheral Inflammation and Nerve Injury
J. Neurosci., May 15, 2003; 23(10): 4117 - 4126.
[Abstract] [Full Text] [PDF]
V. Waetzig and T. Herdegen
A Single c-Jun N-terminal Kinase Isoform (JNK3-p54) Is an Effector in Both Neuronal Differentiation and Cell Death
J. Biol. Chem., January 3, 2003; 278(1): 567 - 572.
[Abstract] [Full Text] [PDF]
C. Holmberg, S. Katz, M. Lerdrup, T. Herdegen, M. Jaattela, A. Aronheim, and T. Kallunki
A Novel Specific Role for Ikappa B Kinase Complex-associated Protein in Cytosolic Stress Signaling
J. Biol. Chem., August 23, 2002; 277(35): 31918 - 31928.
[Abstract] [Full Text] [PDF]
M. J. Savage, Y.-G. Lin, J. R. Ciallella, D. G. Flood, and R. W. Scott
Activation of c-Jun N-Terminal Kinase and p38 in an Alzheimer's Disease Model Is Associated with Amyloid Deposition
J. Neurosci., May 1, 2002; 22(9): 3376 - 3385.
[Abstract] [Full Text] [PDF]
A. W. Harrington, J. Y. Kim, and S. O. Yoon
Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis
J. Neurosci., January 1, 2002; 22(1): 156 - 166.
[Abstract] [Full Text] [PDF]
T. PURVES, A. MIDDLEMAS, S. AGTHONG, E. B. JUDE, A. J. M. BOULTON, P. FERNYHOUGH, and D. R. TOMLINSON
A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy
FASEB J, November 1, 2001; 15(13): 2508 - 2514.
[Abstract] [Full Text] [PDF]
S. J. Crocker, W. R. Lamba, P. D. Smith, S. M. Callaghan, R. S. Slack, H. Anisman, and D. S. Park
c-Jun mediates axotomy-induced dopamine neuron death in vivo
PNAS, October 25, 2001; (2001) 231177098.
[Abstract] [Full Text] [PDF]
A. Takamiya, M. Takeda, A. Yoshida, and H. Kiyama
Expression of Serine Protease Inhibitor 3 in Ocular Tissues in Endotoxin-Induced Uveitis in Rat
Invest. Ophthalmol. Vis. Sci., October 1, 2001; 42(11): 2427 - 2433.
[Abstract] [Full Text] [PDF]
M. Takeda, H. Kato, A. Takamiya, A. Yoshida, and H. Kiyama
Injury-Specific Expression of Activating Transcription Factor-3 in Retinal Ganglion Cells and Its Colocalized Expression with Phosphorylated c-Jun
Invest. Ophthalmol. Vis. Sci., August 1, 2000; 41(9): 2412 - 2421.
[Abstract] [Full Text]
T. Herdegen, K. Mielke, and T. Kallunki
Review : c-Jun and the c-Jun Amino-Terminal Kinases: Bipotential Components of the Neuronal Stress Response
Neuroscientist, May 1, 1999; 5(3): 147 - 154.
[Abstract] [PDF]
S. E. Merritt, M. Mata, D. Nihalani, C. Zhu, X. Hu, and L. B. Holzman
The Mixed Lineage Kinase DLK Utilizes MKK7 and Not MKK4 as Substrate
J. Biol. Chem., April 9, 1999; 274(15): 10195 - 10202.
[Abstract] [Full Text] [PDF]
W. K. Nahm and J. L. Noebels
Nonobligate Role of Early or Sustained Expression of Immediate-Early Gene Proteins c-Fos, c-Jun, and Zif/268 in Hippocampal Mossy Fiber Sprouting
J. Neurosci., November 15, 1998; 18(22): 9245 - 9255.
[Abstract] [Full Text] [PDF]
M. Zagrebelsky, A. Buffo, A. Skerra, M. E. Schwab, P. Strata, and F. Rossi
Retrograde Regulation of Growth-Associated Gene Expression in Adult Rat Purkinje Cells by Myelin-Associated Neurite Growth Inhibitory Proteins
J. Neurosci., October 1, 1998; 18(19): 7912 - 7929.
[Abstract] [Full Text] [PDF]
T. Herdegen, F.-X. Claret, T. Kallunki, A. Martin-Villalba, C. Winter, T. Hunter, and M. Karin
Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury
J. Neurosci., July 15, 1998; 18(14): 5124 - 5135.
[Abstract] [Full Text] [PDF]
K. E. Hall and J. W. Wiley
I. New insights into neuronal injury: a cautionary tale
Am J Physiol Gastrointest Liver Physiol, June 1, 1998; 274(6): G978 - G983.
[Abstract] [Full Text] [PDF]
S. J. Crocker, W. R. Lamba, P. D. Smith, S. M. Callaghan, R. S. Slack, H. Anisman, and D. S. Park
c-Jun mediates axotomy-induced dopamine neuron death in vivo
PNAS, November 6, 2001; 98(23): 13385 - 13390.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|