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The Journal of Neuroscience, March 1, 1998, 18(5):1886-1892

Prenatal Stress Enhances Stress- and Corticotropin-Releasing Factor-Induced Stimulation of Hippocampal Acetylcholine Release in Adult Rats

Jamie C. Day, Muriel Koehl, Veronique Deroche, Michel Le Moal, and Stefania Maccari

Psychobiologie des Comportements Adaptatifs, Institut National de la Santé et de la Recherche Médicale Unité 259, Université Victor Segalen Bordeaux 2, 33077 Bordeaux Cedex, France

There is growing evidence that stressors occurring during pregnancy can impair biological and behavioral responses to stress in the adult offspring. For instance, prenatal stress enhances emotional reactivity, anxiety, and depressive-like behaviors associated with a prolonged stress-induced corticosterone secretion and a reduction in hippocampal corticosteroid receptors. Among the neurotransmitters involved in these hormonal and behavioral responses, acetylcholine may play a critical role. However, it is unknown whether prenatal stressful events also may influence the development of cholinergic systems. In the present study, hippocampal acetylcholine was measured, by in vivo microdialysis, in both male and female adult prenatally stressed rats, under basal conditions, after a mild stress (saline injection) or after intracerebroventricular administration of corticotropin-releasing factor (CRF; 0.1 nM). No difference in basal release of acetylcholine was observed between control and prenatally stressed rats of both genders. Mild stress was found to increase hippocampal acetylcholine release to a greater extent in prenatally stressed rats than in controls. In males, the CRF-induced increase in hippocampal acetylcholine release was larger in prenatally stressed rats, as compared with controls, during the first hour after the injection and in females during the third hour after the injection. These data indicate that prenatal stress has long-term effects on the development of forebrain cholinergic systems. The augmented increase in hippocampal acetylcholine release after the mild stress and CRF injection in prenatally stressed rats may be involved in some of the hormonal and behavioral abnormalities found in prenatally stressed rats.

Key words: prenatal stress; development; acetylcholine; ovine corticotropin-releasing factor; gender; hippocampus

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Copyright © 1998 Society for Neuroscience  0270-6474/98/1851886-07$05.00/0

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