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The Journal of Neuroscience, March 15, 1998, 18(6):1963-1969
Glutamate and GABA Release Are Enhanced by Different Subtypes
of Presynaptic Nicotinic Receptors in the Lateral Geniculate
Nucleus
Jian-Zhong
Guo,
Trevor L.
Tredway, and
Vincent A.
Chiappinelli
Department of Pharmacology, The George Washington University,
School of Medicine and Health Sciences, Washington, D.C. 20037
The functional role of nicotinic acetylcholine receptors (nAChRs)
in the ventral lateral geniculate nucleus (LGNv) was examined in chick
brain slices. Whole-cell patch-clamp recordings of neurons in the LGNv
revealed the presence of bicuculline-resistant spontaneous postsynaptic
currents (PSCs), which were subsequently blocked by
6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), an AMPA receptor antagonist. Carbachol and other nicotinic agonists produced marked increases in the frequency of the glutamatergic spontaneous PSCs in the
presence of tetrodotoxin, whereas they had little or no effect on
current amplitude. The nicotinic receptor antagonist dihydro- -erythroidine (DHE) blocked the carbachol-induced
enhancement of spontaneous glutamatergic PSCs.  -bungarotoxin
(-BgTx) selectively blocked the nAChR-mediated enhancement of
spontaneous glutamatergic PSCs but did not prevent nAChR-mediated
enhancement of spontaneous GABAergic PSCs in the LGNv.
Methyllycaconitine and strychnine, other blockers of nAChRs containing
the 7 subunit, failed to inhibit carbachol's increase of
spontaneous glutamatergic and GABAergic PSCs. These results demonstrate
that the LGNv neurons receive both glutamatergic and GABAergic inputs
and that the release of these transmitters can be modulated by
different presynaptic nAChRs. Thus, the regulation of synaptic efficacy
in the brain by presynaptic nAChRs can be complex, involving multiple
neurotransmitters acting on the same neuron.
Key words:
neuronal nicotinic acetylcholine receptors; presynaptic; glutamate; GABA; modulation; -bungarotoxin; methyllycaconitine; ventral lateral geniculate nucleus
Copyright © 1998 Society for Neuroscience 0270-6474/98/1861963-07$05.00/0
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