 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, March 15, 1998, 18(6):2084-2096
Control of Neural Development and Function in a Thermoregulatory Network by the LIM Homeobox Gene lin-11
Oliver Hobert, Tania D'Alberti, Yanxia Liu, and Gary Ruvkun Massachusetts General Hospital, Department of Molecular Biology, Harvard Medical School, Department of Genetics, Boston, Massachusetts 02114
We show here that the lin-11 LIM homeobox gene is expressed in nine classes of head, ventral cord, and tail neurons and functions at a late step in the development of a subset of these neurons. In a lin-11 null mutant, all lin-11-expressing neurons are generated. Several of these neurons, however, exhibit neuroanatomical as well as functional defects. In the lateral head ganglion, lin-11 functions in a neural network that regulates thermosensory behavior. It is expressed in the AIZ interneuron that processes high temperature input and is required for the function of AIZ in the thermoregulatory neural network. Another LIM homeobox gene, ttx-3, functions in the antagonistic thermoregulatory interneuron AIY (). Thus, distinct LIM genes specify the functions of functionally related antagonistic interneurons within a neural network dedicated for thermoregulatory processes. Both ttx-3 and lin-11 expression are maintained throughout adulthood, suggesting that these LIM homeobox genes play a role in the functional maintenance of this neural circuit. We propose that particular LIM homeobox genes specify the distinct features of functionally related neurons that generate patterned behaviors.
Key words: LIM homeobox gene; neurogenesis; thermotaxis; neural function; axon pathfinding; axon fasciculation
Copyright © 1998 Society for Neuroscience 0270-6474/98/1862084-13$05.00/0
This article has been cited by other articles:
A. Kuhara and I. Mori
Molecular Physiology of the Neural Circuit for Calcineurin-Dependent Associative Learning in Caenorhabditis elegans.
J. Neurosci., September 13, 2006; 26(37): 9355 - 9364.
[Abstract] [Full Text] [PDF]
S. Cordes, C. A. Frank, and G. Garriga
The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions
Development, July 15, 2006; 133(14): 2747 - 2756.
[Abstract] [Full Text] [PDF]
L. Broday, I. Kolotuev, C. Didier, A. Bhoumik, B. P. Gupta, P. W. Sternberg, B. Podbilewicz, and Z. Ronai
The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans
Genes & Dev., October 1, 2004; 18(19): 2380 - 2391.
[Abstract] [Full Text] [PDF]
S. Zhang, I. Sokolchik, G. Blanco, and J. Y. Sze
Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons
Development, April 1, 2004; 131(7): 1629 - 1638.
[Abstract] [Full Text] [PDF]
H. Hutter
Extracellular cues and pioneers act together to guide axons in the ventral cord of C. elegans
Development, November 15, 2003; 130(22): 5307 - 5318.
[Abstract] [Full Text] [PDF]
S. G. Clark and C. Chiu
C. elegans ZAG-1, a Zn-finger-homeodomain protein, regulates axonal development and neuronal differentiation
Development, August 15, 2003; 130(16): 3781 - 3794.
[Abstract] [Full Text] [PDF]
J. Y. Sze and G. Ruvkun
Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity
PNAS, August 5, 2003; 100(16): 9560 - 9565.
[Abstract] [Full Text] [PDF]
B. P. Gupta, M. Wang, and P. W. Sternberg
The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development
Development, June 15, 2003; 130(12): 2589 - 2601.
[Abstract] [Full Text] [PDF]
B. Esmaeili, J. M. Ross, C. Neades, D. M. Miller III, and J. Ahringer
The C. elegans even-skipped homologue, vab-7, specifies DB motoneurone identity and axon trajectory
Development, March 4, 2003; 129(4): 853 - 862.
[Abstract] [Full Text] [PDF]
O. Aurelio, T. Boulin, and O. Hobert
Identification of spatial and temporal cues that regulate postembryonic expression of axon maintenance factors in the C. elegans ventral nerve cord
Development, February 1, 2003; 130(3): 599 - 610.
[Abstract] [Full Text] [PDF]
B. A. Scott, M. S. Avidan, and C. M. Crowder
Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2
Science, June 28, 2002; 296(5577): 2388 - 2391.
[Abstract] [Full Text] [PDF]
D. S. Fay, S. Keenan, and M. Han
fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen
Genes & Dev., February 15, 2002; 16(4): 503 - 517.
[Abstract] [Full Text] [PDF]
T. R. Sarafi-Reinach, T. Melkman, O. Hobert, and P. Sengupta
The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron fates in C. elegans
Development, September 1, 2001; 128(17): 3269 - 3281.
[Abstract] [Full Text] [PDF]
Z. Altun-Gultekin, Y. Andachi, E. L. Tsalik, D. Pilgrim, Y. Kohara, and O. Hobert
A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans
Development, June 1, 2001; 128(11): 1951 - 1969.
[Abstract] [Full Text] [PDF]
D. Fay and M Han
Mutations in cye-1, a Caenorhabditis elegans cyclin E homolog, reveal coordination between cell-cycle control and vulval development
Development, January 9, 2000; 127(18): 4049 - 4060.
[Abstract] [PDF]
S. Certel, P. Clyne, J. Carlson, and W. Johnson
Regulation of central neuron synaptic targeting by the Drosophila POU protein, Acj6
Development, January 6, 2000; 127(11): 2395 - 2405.
[Abstract] [PDF]
H. A. Tissenbaum, J. Hawdon, M. Perregaux, P. Hotez, L. Guarente, and G. Ruvkun
A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum
PNAS, January 4, 2000; 97(1): 460 - 465.
[Abstract] [Full Text] [PDF]
J. Much, D. Slade, K Klampert, G Garriga, and B Wightman
The fax-1 nuclear hormone receptor regulates axon pathfinding and neurotransmitter expression
Development, January 2, 2000; 127(4): 703 - 712.
[Abstract] [PDF]
Y. Zhao, Y.-J. Guo, A. C. Tomac, N. R. Taylor, A. Grinberg, E. J. Lee, S. Huang, and H. Westphal
Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene Lhx8
PNAS, December 21, 1999; 96(26): 15002 - 15006.
[Abstract] [Full Text] [PDF]
A. R. Winnier, J. Y.-J. Meir, J. M. Ross, N. Tavernarakis, M. Driscoll, T. Ishihara, I. Katsura, and D. M. Miller III
UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans
Genes & Dev., November 1, 1999; 13(21): 2774 - 2786.
[Abstract] [Full Text]
N. Wittenburg and R. Baumeister
Thermal avoidance in Caenorhabditis elegans: An approach to the study of nociception
PNAS, August 31, 1999; 96(18): 10477 - 10482.
[Abstract] [Full Text] [PDF]
A. Sagasti, O. Hobert, E. R. Troemel, G. Ruvkun, and C. I. Bargmann
Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4
Genes & Dev., July 15, 1999; 13(14): 1794 - 1806.
[Abstract] [Full Text]
Y. Zhao, H. Z. Sheng, R. Amini, A. Grinberg, E. Lee, S. Huang, M. Taira, and H. Westphal
Control of Hippocampal Morphogenesis and Neuronal Differentiation by the LIM Homeobox Gene Lhx5
Science, May 14, 1999; 284(5417): 1155 - 1158.
[Abstract] [Full Text]
A. Newman, G. Acton, E Hartwieg, H. Horvitz, and P. Sternberg
The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells
Development, January 12, 1999; 126(23): 5319 - 5326.
[Abstract] [PDF]
O Hobert, K Tessmar, and G Ruvkun
The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons
Development, January 4, 1999; 126(7): 1547 - 1562.
[Abstract] [PDF]
J. S. Duerr, D. L. Frisby, J. Gaskin, A. Duke, K. Asermely, D. Huddleston, L. E. Eiden, and J. B. Rand
The cat-1 Gene of Caenorhabditis elegans Encodes a Vesicular Monoamine Transporter Required for Specific Monoamine-Dependent Behaviors
J. Neurosci., January 1, 1999; 19(1): 72 - 84.
[Abstract] [Full Text] [PDF]
D. O'Keefe, S Thor, and J. Thomas
Function and specificity of LIM domains in Drosophila nervous system and wing development
Development, January 10, 1998; 125(19): 3915 - 3923.
[Abstract] [PDF]
|
|
|
|
 |
|