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The Journal of Neuroscience, March 15, 1998, 18(6):2188-2199
Temporal Cortex Activation in Humans Viewing Eye and Mouth
Movements
Aina
Puce1, 2,
Truett
Allison1, 3,
Shlomo
Bentin5,
John C.
Gore4, and
Gregory
McCarthy1, 2, 3
1 Neuropsychology Laboratory, Veterans Administration
Medical Center, West Haven, Connecticut 06516, Departments of
2 Neurosurgery, 3 Neurology, and
4 Diagnostic Radiology, Yale University School of Medicine,
New Haven, Connecticut 06510, and 5 Department of
Psychology and Center for Neural Computation, Hebrew University,
Jerusalem 91905, Israel
We sought to determine whether regions of extrastriate visual
cortex could be activated in subjects viewing eye and mouth movements
that occurred within a stationary face. Eleven subjects participated in
three to five functional magnetic resonance imaging sessions in which
they viewed moving eyes, moving mouths, or movements of check patterns
that occurred in the same spatial location as the eyes or mouth. In
each task, the stimuli were superimposed on a radial background pattern
that continually moved inward to control for the effect of movement per
se. Activation evoked by the radial background was assessed in a
separate control task. Moving eyes and mouths activated a bilateral
region centered in the posterior superior temporal sulcus (STS). The
moving check patterns did not appreciably activate the STS or
surrounding regions. The activation by moving eyes and mouths was
distinct from that elicited by the moving radial background, which
primarily activated the posterior-temporal-occipital fossa and the
lateral occipital sulcus a region corresponding to area MT/V5. Area
MT/V5 was also strongly activated by moving eyes and to a lesser extent
by other moving stimuli. These results suggest that a superior temporal region centered in the STS is preferentially involved in the perception of gaze direction and mouth movements. This region of the STS may be
functionally related to nearby superior temporal regions thought to be
involved in lip-reading and in the perception of hand and body
movement.
Key words:
extrastriate cortex; eye movement; mouth movement; temporal lobe; superior temporal sulcus; gaze direction
Copyright © 1998 Society for Neuroscience 0270-6474/98/1862188-12$05.00/0
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