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The Journal of Neuroscience, March 15, 1998, 18(6):2247-2253
Vagotomy Blocks the Induction of Interleukin-1 (IL-1) mRNA
in the Brain of Rats in Response to Systemic IL-1
Michael K.
Hansen,
Ping
Taishi,
Zutang
Chen, and
James
M.
Krueger
Department of Physiology and Biophysics, The University of
Tennessee, Memphis, Tennessee 38163
There is considerable interest in the mechanisms by which systemic
cytokines signal the CNS to elicit centrally controlled biological
actions. This study determined the effects of intraperitoneal injections of interleukin-1 (IL-1) on IL-1 mRNA and IL-1
receptor accessory protein (IL-1RAP) mRNA production in rat liver and
brain using the reverse transcription-PCR. Saline or IL-1 (0.5 µg/kg) was injected intraperitoneally in subdiaphragmatically
vagotomized and sham-operated (SHAM) rats. All injections were
performed at dark onset, and rats were killed 2 hr after the injection.
In SHAM rats, IL-1 increased IL-1 mRNA levels in the liver,
hypothalamus, hippocampus, and brainstem. Subdiaphragmatic vagotomy
blocked the IL-1-induced increase in IL-1 mRNA in the brainstem
and hippocampus and significantly attenuated the increase in the
hypothalamus. Vagotomy did not affect IL-1-induced IL-1 mRNA
production in the liver. IL-1RAP mRNA was highly expressed in each
region examined; however, no significant differences in IL-1RAP mRNA
production were found in any region after IL-1 injection. The
current results indicate that the vagus nerve is involved in
transmitting cytokine signals to the brain and suggest that the
induction of brain cytokines is a critical step in the pathway by which
vagal-mediated signals result in centrally controlled symptoms of the
acute phase response.
Key words:
interleukin-1; interleukin-1 receptor accessory protein; vagotomy; cytokine; vagus nerve; RT-PCR; mRNA; sleep; fever; acute
phase response
Copyright © 1998 Society for Neuroscience 0270-6474/98/1862247-07$05.00/0
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