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The Journal of Neuroscience, April 1, 1998, 18(7):2646-2652
The Second Messenger cAMP Elicits Eating by an Anatomically
Specific Action in the Perifornical Hypothalamus
Elizabeth R.
Gillard1,
Arshad M.
Khan2,
Rickinder
S.
Grewal1,
Bara
Mouradi1,
Stefany D.
Wolfsohn1, and
B. Glenn
Stanley1
1 Departments of Neuroscience and Psychology and
2 Division of Biomedical Sciences and Department of
Neuroscience, University of California at Riverside, Riverside,
California 92521
We have previously shown that a membrane-permeant analog of cAMP,
8-bromo-cAMP (8-br-cAMP), elicits a vigorous eating response when
microinjected into the perifornical hypothalamus (PFH) or lateral
hypothalamus (LH) of satiated rats, suggesting that increases in cAMP
in these areas may be important in the neural control of eating. To
determine the locus of this effect, we compared the ability of
8-br-cAMP (1-100 nmol/0.3 µl) to elicit eating after microinjection
into the PFH, LH, or the following bracketing areas: the anterior and
posterior LH, paraventricular nucleus of the hypothalamus, thalamus,
and amygdala. 8-br-cAMP at 50 nmol elicited eating ( 3.4 gm in 2 hr)
exclusively in the PFH and LH. At 100 nmol, 8-br-cAMP elicited a larger
response in these areas and elicited a smaller, more variable response
in the thalamus. We similarly mapped the feeding-stimulatory effects of
compounds that increase endogenous cellular cAMP in naive rats.
Combined microinjection of matched doses (300 nmol) of
3-isobutyl-1-methylxanthine and
7-deacetyl-7-O-(N-methylpiperazino)- -butyryl-forskolin
was effective exclusively in the PFH, eliciting an average 2 hr food intake of 8.4 ± 2.0 gm. Collectively, these results suggest that increases in cellular cAMP within a specific brain site, the PFH, may
play a role in the neural stimulation of eating.
Key words:
perifornical hypothalamus; hypothalamus; cAMP; feeding; second messengers; eating; rat
Copyright © 1998 Society for Neuroscience 0270-6474/98/1872646-07$05.00/0
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