WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience The New Axio Examiner
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (47)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sandler, V. M.
Right arrow Articles by Barbara, J.-G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sandler, V. M.
Right arrow Articles by Barbara, J.-G.

 Previous Article  |  Next Article 

The Journal of Neuroscience, June 1, 1999, 19(11):4325-4336

Calcium-Induced Calcium Release Contributes to Action Potential-Evoked Calcium Transients in Hippocampal CA1 Pyramidal Neurons

Vladislav M. Sandler and Jean-Gaël Barbara

New York Medical College, Department of Physiology, Valhalla, New York 10595

Calcium-induced calcium release (CICR) is a mechanism by which local elevations of intracellular calcium (Ca2+) are amplified by Ca2+ release from ryanodine-sensitive Ca2+ stores. CICR is known to be coupled to Ca2+ entry in skeletal muscle, cardiac muscle, and peripheral neurons, but no evidence suggests that such coupling occurs in central neurons during the firing of action potentials. Using fast Ca2+ imaging in CA1 neurons from hippocampal slices, we found evidence for CICR during action potential-evoked Ca2+ transients. A low concentration of caffeine enhanced Ca2+ transient amplitude, whereas a higher concentration reduced it. Simultaneous Ca2+ imaging and whole-cell recordings showed that membrane potential, action potential amplitude, and waveform were unchanged during caffeine application. The enhancement of Ca2+ transients by caffeine was not affected by the L-type channel blocker nifedipine, the phosphodiesterase inhibitor IBMX, the adenylyl cyclase activator forskolin, or the PKA antagonist H-89. However, thapsigargin or ryanodine, which both empty intracellular Ca2+ stores, occluded this effect. In addition, thapsigargin, ryanodine, and cyclopiazonic acid reduced action potential-evoked Ca2+ transients in the absence of caffeine. These results suggest that Ca2+ release from ryanodine-sensitive stores contributes to Ca2+ signals triggered by action potentials in CA1 neurons.

Key words: hippocampus; slices; fura-2; patch clamp; caffeine; thapsigargin

Copyright © 1999 Society for Neuroscience  0270-6474/99/19114325-12$05.00/0


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
N. Kuczewski, C. Porcher, N. Ferrand, H. Fiorentino, C. Pellegrino, R. Kolarow, V. Lessmann, I. Medina, and J.-L. Gaiarsa
Backpropagating Action Potentials Trigger Dendritic Release of BDNF during Spontaneous Network Activity
J. Neurosci., July 2, 2008; 28(27): 7013 - 7023.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Scheuss, R. Yasuda, A. Sobczyk, and K. Svoboda
Nonlinear [Ca2+] Signaling in Dendrites and Spines Caused by Activity-Dependent Depression of Ca2+ Extrusion
J. Neurosci., August 2, 2006; 26(31): 8183 - 8194.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. R. Muotri, K. Nakashima, N. Toni, V. M. Sandler, and F. H. Gage
Development of functional human embryonic stem cell-derived neurons in mouse brain
PNAS, December 20, 2005; 102(51): 18644 - 18648.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. D. King Jr. and S. D. Meriney
Proportion of N-Type Calcium Current Activated by Action Potential Stimuli
J Neurophysiol, December 1, 2005; 94(6): 3762 - 3770.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Q. Liu, B. Chen, M. Yankova, D. K. Morest, E. Maryon, A. R. Hand, M. L. Nonet, and Z.-W. Wang
Presynaptic Ryanodine Receptors Are Required for Normal Quantal Size at the Caenorhabditis elegans Neuromuscular Junction
J. Neurosci., July 20, 2005; 25(29): 6745 - 6754.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Verkhratsky
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Physiol Rev, January 1, 2005; 85(1): 201 - 279.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. W. Wu, C. S. Chan, and J. F. Disterhoft
Slow Afterhyperpolarization Governs the Development of NMDA Receptor-Dependent Afterdepolarization in CA1 Pyramidal Neurons During Synaptic Stimulation
J Neurophysiol, October 1, 2004; 92(4): 2346 - 2356.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. Tully and S. N. Treistman
Distinct Intracellular Calcium Profiles Following Influx Through N- Versus L-Type Calcium Channels: Role of Ca2+-Induced Ca2+ Release
J Neurophysiol, July 1, 2004; 92(1): 135 - 143.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
J. Benda and A. V. M. Herz
A Universal Model for Spike-Frequency Adaptation
Neural Comput., November 1, 2003; 15(11): 2523 - 2564.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. C. Molitor and P. B. Manis
Dendritic Ca2+ Transients Evoked by Action Potentials in Rat Dorsal Cochlear Nucleus Pyramidal and Cartwheel Neurons
J Neurophysiol, April 1, 2003; 89(4): 2225 - 2237.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Balkowiec and D. M. Katz
Cellular Mechanisms Regulating Activity-Dependent Release of Native Brain-Derived Neurotrophic Factor from Hippocampal Neurons
J. Neurosci., December 1, 2002; 22(23): 10399 - 10407.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Kumar and T. C. Foster
17beta -Estradiol Benzoate Decreases the AHP Amplitude in CA1 Pyramidal Neurons
J Neurophysiol, August 1, 2002; 88(2): 621 - 626.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Nakamura, K. Nakamura, N. Lasser-Ross, J.-G. Barbara, V. M. Sandler, and W. N. Ross
Inositol 1,4,5-Trisphosphate (IP3)-Mediated Ca2+ Release Evoked by Metabotropic Agonists and Backpropagating Action Potentials in Hippocampal CA1 Pyramidal Neurons
J. Neurosci., November 15, 2000; 20(22): 8365 - 8376.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. Häusser, N. Spruston, and G. J. Stuart
Diversity and Dynamics of Dendritic Signaling
Science, October 27, 2000; 290(5492): 739 - 744.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
A. G. Teschemacher and E. P. Seward
Bidirectional Modulation of Exocytosis by Angiotensin II Involves Multiple G-Protein-Regulated Transduction Pathways in Chromaffin Cells
J. Neurosci., July 1, 2000; 20(13): 4776 - 4785.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Tsubokawa, S. Offermanns, M. Simon, and M. Kano
Calcium-Dependent Persistent Facilitation of Spike Backpropagation in the CA1 Pyramidal Neurons
J. Neurosci., July 1, 2000; 20(13): 4878 - 4884.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Shah and D. G. Haylett
Ca2+ Channels Involved in the Generation of the Slow Afterhyperpolarization in Cultured Rat Hippocampal Pyramidal Neurons
J Neurophysiol, May 1, 2000; 83(5): 2554 - 2561.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Seutin, F. Mkahli, L. Massotte, and A. Dresse
Calcium Release From Internal Stores Is Required for the Generation of Spontaneous Hyperpolarizations in Dopaminergic Neurons of Neonatal Rats
J Neurophysiol, January 1, 2000; 83(1): 192 - 197.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-