 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, June 1, 1999, 19(11):4325-4336
Calcium-Induced Calcium Release Contributes to Action Potential-Evoked Calcium Transients in Hippocampal CA1 Pyramidal Neurons
Vladislav M. Sandler and Jean-Gaël Barbara New York Medical College, Department of Physiology, Valhalla, New York 10595
Calcium-induced calcium release (CICR) is a mechanism by which local elevations of intracellular calcium (Ca2+) are amplified by Ca2+ release from ryanodine-sensitive Ca2+ stores. CICR is known to be coupled to Ca2+ entry in skeletal muscle, cardiac muscle, and peripheral neurons, but no evidence suggests that such coupling occurs in central neurons during the firing of action potentials. Using fast Ca2+ imaging in CA1 neurons from hippocampal slices, we found evidence for CICR during action potential-evoked Ca2+ transients. A low concentration of caffeine enhanced Ca2+ transient amplitude, whereas a higher concentration reduced it. Simultaneous Ca2+ imaging and whole-cell recordings showed that membrane potential, action potential amplitude, and waveform were unchanged during caffeine application. The enhancement of Ca2+ transients by caffeine was not affected by the L-type channel blocker nifedipine, the phosphodiesterase inhibitor IBMX, the adenylyl cyclase activator forskolin, or the PKA antagonist H-89. However, thapsigargin or ryanodine, which both empty intracellular Ca2+ stores, occluded this effect. In addition, thapsigargin, ryanodine, and cyclopiazonic acid reduced action potential-evoked Ca2+ transients in the absence of caffeine. These results suggest that Ca2+ release from ryanodine-sensitive stores contributes to Ca2+ signals triggered by action potentials in CA1 neurons.
Key words: hippocampus; slices; fura-2; patch clamp; caffeine; thapsigargin
Copyright © 1999 Society for Neuroscience 0270-6474/99/19114325-12$05.00/0
This article has been cited by other articles:
T. Blackmer, S. P. Kuo, K. J. Bender, P. F. Apostolides, and L. O. Trussell
Dendritic Calcium Channels and Their Activation by Synaptic Signals in Auditory Coincidence Detector Neurons
J Neurophysiol, August 1, 2009; 102(2): 1218 - 1226.
[Abstract] [Full Text] [PDF]
N. Kuczewski, C. Porcher, N. Ferrand, H. Fiorentino, C. Pellegrino, R. Kolarow, V. Lessmann, I. Medina, and J.-L. Gaiarsa
Backpropagating Action Potentials Trigger Dendritic Release of BDNF during Spontaneous Network Activity
J. Neurosci., July 2, 2008; 28(27): 7013 - 7023.
[Abstract] [Full Text] [PDF]
V. Scheuss, R. Yasuda, A. Sobczyk, and K. Svoboda
Nonlinear [Ca2+] Signaling in Dendrites and Spines Caused by Activity-Dependent Depression of Ca2+ Extrusion
J. Neurosci., August 2, 2006; 26(31): 8183 - 8194.
[Abstract] [Full Text] [PDF]
A. R. Muotri, K. Nakashima, N. Toni, V. M. Sandler, and F. H. Gage
Development of functional human embryonic stem cell-derived neurons in mouse brain
PNAS, December 20, 2005; 102(51): 18644 - 18648.
[Abstract] [Full Text] [PDF]
J. D. King Jr. and S. D. Meriney
Proportion of N-Type Calcium Current Activated by Action Potential Stimuli
J Neurophysiol, December 1, 2005; 94(6): 3762 - 3770.
[Abstract] [Full Text] [PDF]
Q. Liu, B. Chen, M. Yankova, D. K. Morest, E. Maryon, A. R. Hand, M. L. Nonet, and Z.-W. Wang
Presynaptic Ryanodine Receptors Are Required for Normal Quantal Size at the Caenorhabditis elegans Neuromuscular Junction
J. Neurosci., July 20, 2005; 25(29): 6745 - 6754.
[Abstract] [Full Text] [PDF]
A. Verkhratsky
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Physiol Rev, January 1, 2005; 85(1): 201 - 279.
[Abstract] [Full Text] [PDF]
W. W. Wu, C. S. Chan, and J. F. Disterhoft
Slow Afterhyperpolarization Governs the Development of NMDA Receptor-Dependent Afterdepolarization in CA1 Pyramidal Neurons During Synaptic Stimulation
J Neurophysiol, October 1, 2004; 92(4): 2346 - 2356.
[Abstract] [Full Text] [PDF]
K. Tully and S. N. Treistman
Distinct Intracellular Calcium Profiles Following Influx Through N- Versus L-Type Calcium Channels: Role of Ca2+-Induced Ca2+ Release
J Neurophysiol, July 1, 2004; 92(1): 135 - 143.
[Abstract] [Full Text] [PDF]
S. C. Molitor and P. B. Manis
Dendritic Ca2+ Transients Evoked by Action Potentials in Rat Dorsal Cochlear Nucleus Pyramidal and Cartwheel Neurons
J Neurophysiol, April 1, 2003; 89(4): 2225 - 2237.
[Abstract] [Full Text] [PDF]
A. Balkowiec and D. M. Katz
Cellular Mechanisms Regulating Activity-Dependent Release of Native Brain-Derived Neurotrophic Factor from Hippocampal Neurons
J. Neurosci., December 1, 2002; 22(23): 10399 - 10407.
[Abstract] [Full Text] [PDF]
A. Kumar and T. C. Foster
17beta -Estradiol Benzoate Decreases the AHP Amplitude in CA1 Pyramidal Neurons
J Neurophysiol, August 1, 2002; 88(2): 621 - 626.
[Abstract] [Full Text] [PDF]
T. C. Foster and A. Kumar
Calcium Dysregulation in the Aging Brain
Neuroscientist, August 1, 2002; 8(4): 297 - 301.
[Abstract] [PDF]
M. A. Albrecht, S. L. Colegrove, J. Hongpaisan, N. B. Pivovarova, S. B. Andrews, and D. D. Friel
Multiple Modes of Calcium-Induced Calcium Release in Sympathetic Neurons I: Attenuation of Endoplasmic Reticulum Ca2+ Accumulation at Low [Ca2+]i during Weak Depolarization
J. Gen. Physiol., July 1, 2001; 118(1): 83 - 100.
[Abstract] [Full Text] [PDF]
J. Hongpaisan, N. B. Pivovarova, S. L. Colegrove, R. D. Leapman, D. D. Friel, and S. B. Andrews
Multiple Modes of Calcium-Induced Calcium Release in Sympathetic Neurons II: A [Ca2+]i- and Location-Dependent Transition from Endoplasmic Reticulum Ca Accumulation to Net Ca Release
J. Gen. Physiol., July 1, 2001; 118(1): 101 - 112.
[Abstract] [Full Text] [PDF]
T. Nakamura, K. Nakamura, N. Lasser-Ross, J.-G. Barbara, V. M. Sandler, and W. N. Ross
Inositol 1,4,5-Trisphosphate (IP3)-Mediated Ca2+ Release Evoked by Metabotropic Agonists and Backpropagating Action Potentials in Hippocampal CA1 Pyramidal Neurons
J. Neurosci., November 15, 2000; 20(22): 8365 - 8376.
[Abstract] [Full Text] [PDF]
T. Akita and K. Kuba
Functional Triads Consisting of Ryanodine Receptors, Ca2+ Channels, and Ca2+-Activated K+ Channels in Bullfrog Sympathetic Neurons: Plastic Modulation of Action Potential
J. Gen. Physiol., November 1, 2000; 116(5): 697 - 720.
[Abstract] [Full Text] [PDF]
J. S. Marchant and I. Parker
Functional Interactions in Ca2+ Signaling over Different Time and Distance Scales
J. Gen. Physiol., November 1, 2000; 116(5): 691 - 696.
[Full Text] [PDF]
M. Häusser, N. Spruston, and G. J. Stuart
Diversity and Dynamics of Dendritic Signaling
Science, October 27, 2000; 290(5492): 739 - 744.
[Abstract] [Full Text]
A. G. Teschemacher and E. P. Seward
Bidirectional Modulation of Exocytosis by Angiotensin II Involves Multiple G-Protein-Regulated Transduction Pathways in Chromaffin Cells
J. Neurosci., July 1, 2000; 20(13): 4776 - 4785.
[Abstract] [Full Text] [PDF]
H. Tsubokawa, S. Offermanns, M. Simon, and M. Kano
Calcium-Dependent Persistent Facilitation of Spike Backpropagation in the CA1 Pyramidal Neurons
J. Neurosci., July 1, 2000; 20(13): 4878 - 4884.
[Abstract] [Full Text] [PDF]
S. M Beier and M. E Barish
Cholinergic stimulation enhances cytosolic calcium ion accumulation in mouse hippocampal CA1 pyramidal neurones during short action potential trains
J. Physiol., July 1, 2000; 526(1): 129 - 142.
[Abstract] [Full Text] [PDF]
M. Shah and D. G. Haylett
Ca2+ Channels Involved in the Generation of the Slow Afterhyperpolarization in Cultured Rat Hippocampal Pyramidal Neurons
J Neurophysiol, May 1, 2000; 83(5): 2554 - 2561.
[Abstract] [Full Text] [PDF]
V. Seutin, F. Mkahli, L. Massotte, and A. Dresse
Calcium Release From Internal Stores Is Required for the Generation of Spontaneous Hyperpolarizations in Dopaminergic Neurons of Neonatal Rats
J Neurophysiol, January 1, 2000; 83(1): 192 - 197.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|