 |
 Previous Article | Next Article 
The Journal of Neuroscience, June 1, 1999, 19(11):4337-4348
The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC
to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of
Hippocampus
Erik D.
Roberson ,
Joey D.
English ,
J. Paige
Adams ,
Joel
C.
Selcher ,
Christine
Kondratick, and
J. David
Sweatt
Division of Neuroscience, Baylor College of Medicine, Houston,
Texas 77030
Activation of the mitogen-activated protein kinase (MAPK) cascade
recently was discovered to play an important role in synaptic plasticity in area CA1 of rat hippocampus. However, the upstream mechanisms regulating MAPK activity and the downstream effectors of
MAPK in the hippocampus are uncharacterized. In the present studies we
observed that hippocampal MAPK activation is regulated by both the PKA
and PKC systems; moreover, we found that a wide variety of
neuromodulatory neurotransmitter receptors (metabotropic glutamate
receptors, muscarinic acetylcholine receptors, dopamine receptors, and
 -adrenergic receptors) couple to MAPK activation via these two
cascades. In additional studies we observed that PKC is a powerful
regulator of CREB phosphorylation in area CA1. MAPK plays a critical
role in transcriptional regulation by PKC, because MAPK activation is a
necessary component for increased CREB phosphorylation in response to
the activation of this kinase. Surprisingly, we also observed that MAPK
activation is necessary for PKA coupling to CREB phosphorylation in
area CA1. Overall, these studies indicate an unexpected richness of
diversity in the regulation of MAPK in the hippocampus and suggest the
possibility of a broad role for the MAPK cascade in regulating gene
expression in long-term forms of hippocampal synaptic plasticity.
Key words:
MAPK; PKA; PKC; CREB; hippocampus; LTP; learning and
memory
Copyright © 1999 Society for Neuroscience 0270-6474/99/19114337-12$05.00/0
This article has been cited by other articles:
|
|
|
|
 
J.-H. Han, A. P. Yiu, C. J. Cole, H.-L. Hsiang, R. L. Neve, and S. A. Josselyn
Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear
Learn. Mem.,
May 30, 2008;
15(6):
443 - 453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Antion, L. Hou, H. Wong, C. A. Hoeffer, and E. Klann
mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice
Mol. Cell. Biol.,
May 1, 2008;
28(9):
2996 - 3007.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hu, I. V. Lund, M. C. Gravielle, D. H. Farb, A. R. Brooks-Kayal, and S. J. Russek
Surface Expression of GABAA Receptors Is Transcriptionally Controlled by the Interplay of cAMP-response Element-binding Protein and Its Binding Partner Inducible cAMP Early Repressor
J. Biol. Chem.,
April 4, 2008;
283(14):
9328 - 9340.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Hobbs, M. Thoresen, A. Tucker, K. Aquilina, E. Chakkarapani, and J. Dingley
Xenon and Hypothermia Combine Additively, Offering Long-Term Functional and Histopathologic Neuroprotection After Neonatal Hypoxia/Ischemia
Stroke,
April 1, 2008;
39(4):
1307 - 1313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-Y. Ho, P.-J. Lu, M. Hsiao, H.-R. Hwang, Y.-C. Tseng, M.-H. Yen, and C.-J. Tseng
Adenosine Modulates Cardiovascular Functions Through Activation of Extracellular Signal-Regulated Kinases 1 and 2 and Endothelial Nitric Oxide Synthase in the Nucleus Tractus Solitarii of Rats
Circulation,
February 12, 2008;
117(6):
773 - 780.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Volk, B. E. Pfeiffer, J. R. Gibson, and K. M. Huber
Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long-Term Depression That Is Affected in Fragile X Syndrome Mental Retardation
J. Neurosci.,
October 24, 2007;
27(43):
11624 - 11634.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Grabauskas, B. Lancaster, V. O'Connor, and H. V. Wheal
Protein kinase signalling requirements for metabotropic action of kainate receptors in rat CA1 pyramidal neurones
J. Physiol.,
March 1, 2007;
579(2):
363 - 373.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Carrasquillo and R. W. Gereau IV
Activation of the Extracellular Signal-Regulated Kinase in the Amygdala Modulates Pain Perception
J. Neurosci.,
February 14, 2007;
27(7):
1543 - 1551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. ZHANG and M. XU
Opposite regulation of cocaine-induced intracellular signaling and gene expression by dopamine D1 and D3 receptors.
Ann. N.Y. Acad. Sci.,
August 1, 2006;
1074:
1 - 12.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wu, M. J. Rowan, and R. Anwyl
Long-Term Potentiation Is Mediated by Multiple Kinase Cascades Involving CaMKII or Either PKA or p42/44 MAPK in the Adult Rat Dentate Gyrus In Vitro
J Neurophysiol,
June 1, 2006;
95(6):
3519 - 3527.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Karpova, M. Mikhaylova, U. Thomas, T. Knopfel, and T. Behnisch
Involvement of protein synthesis and degradation in long-term potentiation of Schaffer collateral CA1 synapses.
J. Neurosci.,
May 3, 2006;
26(18):
4949 - 4955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Trifilieff, C. Herry, P. Vanhoutte, J. Caboche, A. Desmedt, G. Riedel, N. Mons, and J. Micheau
Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation
Learn. Mem.,
May 1, 2006;
13(3):
349 - 358.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Volk, C. A. Daly, and K. M. Huber
Differential Roles for Group 1 mGluR Subtypes in Induction and Expression of Chemically Induced Hippocampal Long-Term Depression
J Neurophysiol,
April 1, 2006;
95(4):
2427 - 2438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Fumagalli, A. Frasca, M. Sparta, F. Drago, G. Racagni, and M. A. Riva
Long-Term Exposure to the Atypical Antipsychotic Olanzapine Differently Up-Regulates Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylation in Subcellular Compartments of Rat Prefrontal Cortex
Mol. Pharmacol.,
April 1, 2006;
69(4):
1366 - 1372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Cen, A. Nitta, S. Ohya, Y. Zhao, N. Ozawa, A. Mouri, D. Ibi, L. Wang, M. Suzuki, K. Saito, et al.
An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway.
J. Neurosci.,
March 22, 2006;
26(12):
3335 - 3344.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Wei, K. I. Vadakkan, H. Toyoda, L.-J. Wu, M.-G. Zhao, H. Xu, F. W.F. Shum, Y. H. Jia, and M. Zhuo
Calcium Calmodulin-Stimulated Adenylyl Cyclases Contribute to Activation of Extracellular Signal-Regulated Kinase in Spinal Dorsal Horn Neurons in Adult Rats and Mice
J. Neurosci.,
January 18, 2006;
26(3):
851 - 861.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-Y. Hu, F. Wu, and S. Schacher
Two Signaling Pathways Regulate the Expression and Secretion of a Neuropeptide Required for Long-Term Facilitation in Aplysia
J. Neurosci.,
January 18, 2006;
26(3):
1026 - 1035.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Navakkode, S. Sajikumar, and J. U. Frey
Mitogen-Activated Protein Kinase-Mediated Reinforcement of Hippocampal Early Long-Term Depression by the Type IV-Specific Phosphodiesterase Inhibitor Rolipram and Its Effect on Synaptic Tagging
J. Neurosci.,
November 16, 2005;
25(46):
10664 - 10670.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Alvarez-Jaimes, M. Feliciano-Rivera, M. Centeno-Gonzalez, and C. S. Maldonado-Vlaar
Contributions of the Mitogen-Activated Protein Kinase and Protein Kinase C Cascades in Spatial Learning and Memory Mediated by the Nucleus Accumbens
J. Pharmacol. Exp. Ther.,
September 1, 2005;
314(3):
1144 - 1157.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Ribeiro, M. G. Schofield, I. Kemenes, M. O'Shea, G. Kemenes, and P. R. Benjamin
Activation of MAPK is necessary for long-term memory consolidation following food-reward conditioning
Learn. Mem.,
September 1, 2005;
12(5):
538 - 545.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Huang, J. K. Chotiner, and O. Steward
The mRNA for Elongation Factor 1{alpha} Is Localized in Dendrites and Translated in Response to Treatments That Induce Long-Term Depression
J. Neurosci.,
August 3, 2005;
25(31):
7199 - 7209.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Y. Yuen, Q. Jiang, P. Chen, Z. Gu, J. Feng, and Z. Yan
Serotonin 5-HT1A Receptors Regulate NMDA Receptor Channels through a Microtubule-Dependent Mechanism
J. Neurosci.,
June 8, 2005;
25(23):
5488 - 5501.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. S. Rani, M. Qiang, and M. K. Ticku
Potential Role of cAMP Response Element-Binding Protein in Ethanol-Induced N-Methyl-D-aspartate Receptor 2B Subunit Gene Transcription in Fetal Mouse Cortical Cells
Mol. Pharmacol.,
June 1, 2005;
67(6):
2126 - 2136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Sala, G. Roussignol, J. Meldolesi, and L. Fagni
Key Role of the Postsynaptic Density Scaffold Proteins Shank and Homer in the Functional Architecture of Ca2+ Homeostasis at Dendritic Spines in Hippocampal Neurons
J. Neurosci.,
May 4, 2005;
25(18):
4587 - 4592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Voulalas, L. Holtzclaw, J. Wolstenholme, J. T. Russell, and S. E. Hyman
Metabotropic Glutamate Receptors and Dopamine Receptors Cooperate to Enhance Extracellular Signal-Regulated Kinase Phosphorylation in Striatal Neurons
J. Neurosci.,
April 13, 2005;
25(15):
3763 - 3773.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Limback-Stokin, E. Korzus, R. Nagaoka-Yasuda, and M. Mayford
Nuclear Calcium/Calmodulin Regulates Memory Consolidation
J. Neurosci.,
December 1, 2004;
24(48):
10858 - 10867.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Kawasaki, T. Kohno, Z.-Y. Zhuang, G. J. Brenner, H. Wang, C. Van Der Meer, K. Befort, C. J. Woolf, and R.-R. Ji
Ionotropic and Metabotropic Receptors, Protein Kinase A, Protein Kinase C, and Src Contribute to C-Fiber-Induced ERK Activation and cAMP Response Element-Binding Protein Phosphorylation in Dorsal Horn Neurons, Leading to Central Sensitization
J. Neurosci.,
September 22, 2004;
24(38):
8310 - 8321.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Cardenas, M. Muller, E. Jaimovich, F. Perez, D. Buchuk, A. F. G. Quest, and M. A. Carrasco
Depolarization of Skeletal Muscle Cells induces Phosphorylation of cAMP Response Element Binding Protein via Calcium and Protein Kinase C{alpha}
J. Biol. Chem.,
September 10, 2004;
279(37):
39122 - 39131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Lopez-Toledano, C. Redondo, M. V.T. Lobo, D. Reimers, A. S. Herranz, C. L. Paino, and E. Bazan
Tyrosine Hydroxylase Induction by Basic Fibroblast Growth Factor and Cyclic AMP Analogs in Striatal Neural Stem Cells: Role of ERK1/ERK2 Mitogen-activated Protein Kinase and Protein Kinase C
J. Histochem. Cytochem.,
September 1, 2004;
52(9):
1177 - 1189.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Muller and E. M. Unterwald
In Vivo Regulation of Extracellular Signal-Regulated Protein Kinase (ERK) and Protein Kinase B (Akt) Phosphorylation by Acute and Chronic Morphine
J. Pharmacol. Exp. Ther.,
August 1, 2004;
310(2):
774 - 782.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ghirardi, F. Benfenati, S. Giovedi, F. Fiumara, C. Milanese, and P. G. Montarolo
Inhibition of Neurotransmitter Release by a Nonphysiological Target Requires Protein Synthesis and Involves cAMP-Dependent and Mitogen-Activated Protein Kinases
J. Neurosci.,
May 26, 2004;
24(21):
5054 - 5062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Gallagher, C. A. Daly, M. F. Bear, and K. M. Huber
Extracellular Signal-Regulated Protein Kinase Activation Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression in Hippocampal Area CA1
J. Neurosci.,
May 19, 2004;
24(20):
4859 - 4864.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Zhang, D. Lou, H. Jiao, D. Zhang, X. Wang, Y. Xia, J. Zhang, and M. Xu
Cocaine-Induced Intracellular Signaling and Gene Expression Are Oppositely Regulated by the Dopamine D1 and D3 Receptors
J. Neurosci.,
March 31, 2004;
24(13):
3344 - 3354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Wang, D. M. Walsh, M. J. Rowan, D. J. Selkoe, and R. Anwyl
Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid {beta}-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5
J. Neurosci.,
March 31, 2004;
24(13):
3370 - 3378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kaloulis, S. Chera, M. Hassel, D. Gauchat, and B. Galliot
Reactivation of developmental programs: The cAMP-response element-binding protein pathway is involved in hydra head regeneration
PNAS,
February 24, 2004;
101(8):
2363 - 2368.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Runyan, A. N. Moore, and P. K. Dash
A Role for Prefrontal Cortex in Memory Storage for Trace Fear Conditioning
J. Neurosci.,
February 11, 2004;
24(6):
1288 - 1295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Zhao, R. Bianchi, M. Wang, and R. K. S. Wong
Extracellular Signal-Regulated Kinase 1/2 Is Required for the Induction of Group I Metabotropic Glutamate Receptor-Mediated Epileptiform Discharges
J. Neurosci.,
January 7, 2004;
24(1):
76 - 84.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Sananbenesi, A. Fischer, C. Schrick, J. Spiess, and J. Radulovic
Mitogen-Activated Protein Kinase Signaling in the Hippocampus and Its Modulation by Corticotropin-Releasing Factor Receptor 2: A Possible Link between Stress and Fear Memory
J. Neurosci.,
December 10, 2003;
23(36):
11436 - 11443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Otani, H. Daniel, M.-P. Roisin, and F. Crepel
Dopaminergic Modulation of Long-term Synaptic Plasticity in Rat Prefrontal Neurons
Cereb Cortex,
November 1, 2003;
13(11):
1251 - 1256.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hassan, B. Duong, K.-S. Kim, and M. F. Miles
Pharmacogenomic Analysis of Mechanisms Mediating Ethanol Regulation of Dopamine {beta}-Hydroxylase
J. Biol. Chem.,
October 3, 2003;
278(40):
38860 - 38869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-J. Hu, K. S. Glauner, and R. W. Gereau IV
ERK Integrates PKA and PKC Signaling in Superficial Dorsal Horn Neurons. I. Modulation of A-Type K+ Currents
J Neurophysiol,
September 1, 2003;
90(3):
1671 - 1679.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Cancedda, E. Putignano, S. Impey, L. Maffei, G. M. Ratto, and T. Pizzorusso
Patterned Vision Causes CRE-Mediated Gene Expression in the Visual Cortex through PKA and ERK
J. Neurosci.,
August 6, 2003;
23(18):
7012 - 7020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K. Ho, M. Mackova, C. Cho, and C. L. Chik
Regulation of 90-Kilodalton Ribosomal S6 Kinase Phosphorylation in the Rat Pineal Gland
Endocrinology,
August 1, 2003;
144(8):
3344 - 3350.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-L. Chien, K.-C. Liang, C.-M. Teng, S.-C. Kuo, F.-Y. Lee, and W.-M. Fu
Enhancement of Long-Term Potentiation by a Potent Nitric Oxide-Guanylyl Cyclase Activator, 3-(5-Hydroxymethyl-2-furyl)-1-benzyl-indazole
Mol. Pharmacol.,
June 1, 2003;
63(6):
1322 - 1328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. B. Renden and K. Broadie
Mutation and Activation of Galpha s Similarly Alters Pre- and Postsynaptic Mechanisms Modulating Neurotransmission
J Neurophysiol,
May 1, 2003;
89(5):
2620 - 2638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Opazo, A. M. Watabe, S. G. N. Grant, and T. J. O'Dell
Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms
J. Neurosci.,
May 1, 2003;
23(9):
3679 - 3688.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Sharma, C. M. Sherff, J. Shobe, M. W. Bagnall, M. A. Sutton, and T. J. Carew
Differential Role of Mitogen-Activated Protein Kinase in Three Distinct Phases of Memory for Sensitization in Aplysia
J. Neurosci.,
May 1, 2003;
23(9):
3899 - 3907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Selcher, E. J. Weeber, J. Christian, T. Nekrasova, G. E. Landreth, and J. D. Sweatt
A Role for ERK MAP Kinase in Physiologic Temporal Integration in Hippocampal Area CA1
Learn. Mem.,
January 1, 2003;
10(1):
26 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Berkeley and A. I. Levey
Cell-Specific Extracellular Signal-Regulated Kinase Activation by Multiple G Protein-Coupled Receptor Families in Hippocampus
Mol. Pharmacol.,
January 1, 2003;
63(1):
128 - 135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Schrader, A. E. Anderson, A. Mayne, P. J. Pfaffinger, and J. D. Sweatt
PKA Modulation of Kv4.2-Encoded A-Type Potassium Channels Requires Formation of a Supramolecular Complex
J. Neurosci.,
December 1, 2002;
22(23):
10123 - 10133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.-L. Yuan, J. P. Adams, M. Swank, J. D. Sweatt, and D. Johnston
Protein Kinase Modulation of Dendritic K+ Channels in Hippocampus Involves a Mitogen-Activated Protein Kinase Pathway
J. Neurosci.,
June 15, 2002;
22(12):
4860 - 4868.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Watanabe, D. A. Hoffman, M. Migliore, and D. Johnston
Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons
PNAS,
June 11, 2002;
99(12):
8366 - 8371.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. T. Scharf, N. H. Woo, K. M. Lattal, J. Z. Young, P. V. Nguyen, and T. Abel
Protein Synthesis Is Required for the Enhancement of Long-Term Potentiation and Long-Term Memory by Spaced Training
J Neurophysiol,
June 1, 2002;
87(6):
2770 - 2777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wu, J. Li, K.-P. Huang, and F. L. Huang
Attenuation of Protein Kinase C and cAMP-dependent Protein Kinase Signal Transduction in the Neurogranin Knockout Mouse
J. Biol. Chem.,
May 24, 2002;
277(22):
19498 - 19505.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Asher, T. D. Cunningham, L. Yao, A. S. Gordon, and I. Diamond
Ethanol Stimulates cAMP-Responsive Element (CRE)-Mediated Transcription via CRE-Binding Protein and cAMP-Dependent Protein Kinase
J. Pharmacol. Exp. Ther.,
April 1, 2002;
301(1):
66 - 70.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Vanhoose, M. Emery, L. Jimenez, and D. G. Winder
ERK Activation by G-protein-coupled Receptors in Mouse Brain Is Receptor Identity-specific
J. Biol. Chem.,
March 8, 2002;
277(11):
9049 - 9053.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
