 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, June 1, 1999, 19(11):4428-4436
Chemoattraction and Chemorepulsion of Olfactory Bulb Axons by Different Secreted Semaphorins
Fernando de Castro1, Lingjia Hu2, Harry Drabkin2, Constantino Sotelo1, and Alain Chédotal1 1 Institut National de la Santé et de la Recherche Médicale U106, Hôpital de la Salpêtrière, 75013 Paris, France, and 2 University of Colorado Health Sciences Center, Denver, Colorado 80262
During development, growth cones can be guided at a distance by diffusible factors, which are attractants and/or repellents. The semaphorins are the largest family of repulsive axon guidance molecules. Secreted semaphorins bind neuropilin receptors and repel sensory, sympathetic, motor, and forebrain axons. We found that in rat embryos, the olfactory epithelium releases a diffusible factor that repels olfactory bulb axons. In addition, Sema A and Sema IV, but not Sema III, Sema E, or Sema H, are able to orient in vitro the growth of olfactory bulb axons; Sema IV has a strong repulsive action, whereas Sema A appears to attract those axons. The expression patterns of sema A and sema IV in the developing olfactory system confirm that they may play a cooperative role in the formation of the lateral olfactory tract. This also represents a further evidence for a chemoattractive function of secreted semaphorins.
Key words: semaphorin; olfactory system; chemorepulsion; chemoattraction; development; neuropilin
Copyright © 1999 Society for Neuroscience 0270-6474/99/19114428-09$05.00/0
This article has been cited by other articles:
K. Yamauchi, S. Mizushima, A. Tamada, N. Yamamoto, S. Takashima, and F. Murakami
FGF8 Signaling Regulates Growth of Midbrain Dopaminergic Axons by Inducing Semaphorin 3F
J. Neurosci., April 1, 2009; 29(13): 4044 - 4055.
[Abstract] [Full Text] [PDF]
K. T. Nguyen-Ba-Charvet, T. Di Meglio, C. Fouquet, and A. Chedotal
Robos and Slits Control the Pathfinding and Targeting of Mouse Olfactory Sensory Axons
J. Neurosci., April 16, 2008; 28(16): 4244 - 4249.
[Abstract] [Full Text] [PDF]
J. H. Cho, M. Lepine, W. Andrews, J. Parnavelas, and J.-F. Cloutier
Requirement for Slit-1 and Robo-2 in Zonal Segregation of Olfactory Sensory Neuron Axons in the Main Olfactory Bulb
J. Neurosci., August 22, 2007; 27(34): 9094 - 9104.
[Abstract] [Full Text] [PDF]
C. Fouquet, T. Di Meglio, L. Ma, T. Kawasaki, H. Long, T. Hirata, M. Tessier-Lavigne, A. Chedotal, and K. T. Nguyen-Ba-Charvet
Robo1 and Robo2 Control the Development of the Lateral Olfactory Tract
J. Neurosci., March 14, 2007; 27(11): 3037 - 3045.
[Abstract] [Full Text] [PDF]
B. Saha, P. Hari, D. Huilgol, and S. Tole
Dual Role for LIM-Homeodomain Gene Lhx2 in the Formation of the Lateral Olfactory Tract
J. Neurosci., February 28, 2007; 27(9): 2290 - 2297.
[Abstract] [Full Text] [PDF]
T. Kawasaki, K. Ito, and T. Hirata
Netrin 1 regulates ventral tangential migration of guidepost neurons in the lateral olfactory tract
Development, March 1, 2006; 133(5): 845 - 853.
[Abstract] [Full Text] [PDF]
M. Autiero, F. De Smet, F. Claes, and P. Carmeliet
Role of neural guidance signals in blood vessel navigation
Cardiovasc Res, February 15, 2005; 65(3): 629 - 638.
[Abstract] [Full Text] [PDF]
T. Tanno, S. Takenaka, and S. Tsuyama
Expression and Function of Slit1{alpha}, a Novel Alternative Splicing Product for Slit1
J. Biochem., November 1, 2004; 136(5): 575 - 581.
[Abstract] [Full Text] [PDF]
A. Sahay, M. E. Molliver, D. D. Ginty, and A. L. Kolodkin
Semaphorin 3F Is Critical for Development of Limbic System Circuitry and Is Required in Neurons for Selective CNS Axon Guidance Events
J. Neurosci., July 30, 2003; 23(17): 6671 - 6680.
[Abstract] [Full Text] [PDF]
F. de Castro
Chemotropic Molecules: Guides for Axonal Pathfinding and Cell Migration During CNS Development
Physiology, June 1, 2003; 18(3): 130 - 136.
[Abstract] [Full Text] [PDF]
T. Xiao, W. Shoji, W. Zhou, F. Su, and J. Y. Kuwada
Transmembrane Sema4E Guides Branchiomotor Axons to Their Targets in Zebrafish
J. Neurosci., May 15, 2003; 23(10): 4190 - 4198.
[Abstract] [Full Text] [PDF]
A. T. Legg and T. P. O'Connor
Gradients and Growth Cone Guidance of Grasshopper Neurons
J. Histochem. Cytochem., April 1, 2003; 51(4): 445 - 454.
[Abstract] [Full Text] [PDF]
C. N. G. Anderson, K. Ohta, M. M. Quick, A. Fleming, R. Keynes, and D. Tannahill
Molecular analysis of axon repulsion by the notochord
Development, March 15, 2003; 130(6): 1123 - 1133.
[Abstract] [Full Text] [PDF]
N. Spassky, F. de Castro, B. Le Bras, K. Heydon, F. Queraud-LeSaux, E. Bloch-Gallego, A. Chedotal, B. Zalc, and J.-L. Thomas
Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1
J. Neurosci., July 15, 2002; 22(14): 5992 - 6004.
[Abstract] [Full Text] [PDF]
K. T. Nguyen-Ba-Charvet, A. S. Plump, M. Tessier-Lavigne, and A. Chedotal
Slit1 and Slit2 Proteins Control the Development of the Lateral Olfactory Tract
J. Neurosci., July 1, 2002; 22(13): 5473 - 5480.
[Abstract] [Full Text] [PDF]
A. Walz, I. Rodriguez, and P. Mombaerts
Aberrant Sensory Innervation of the Olfactory Bulb in Neuropilin-2 Mutant Mice
J. Neurosci., May 15, 2002; 22(10): 4025 - 4035.
[Abstract] [Full Text] [PDF]
Z. He, K. C. Wang, V. Koprivica, G. Ming, and H.-J. Song
Knowing How to Navigate: Mechanisms of Semaphorin Signaling in the Nervous System
Sci. Signal., February 12, 2002; 2002(119): re1 - re1.
[Abstract] [Full Text] [PDF]
T. Fujii, F. Nakao, Y. Shibata, G. Shioi, E. Kodama, H. Fujisawa, and S. Takagi
Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis
Development, January 5, 2002; 129(9): 2053 - 2063.
[Abstract] [Full Text] [PDF]
K. Patel, J. A. B. Nash, A. Itoh, Z. Liu, V. Sundaresan, and A. Pini
Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons
Development, December 15, 2001; 128(24): 5031 - 5037.
[Abstract] [Full Text] [PDF]
S. E. Arnold, L.-Y. Han, P. J. Moberg, B. I. Turetsky, R. E. Gur, J. Q. Trojanowski, and C.-G. Hahn
Dysregulation of Olfactory Receptor Neuron Lineage in Schizophrenia
Arch Gen Psychiatry, September 1, 2001; 58(9): 829 - 835.
[Abstract] [Full Text] [PDF]
A. Acebes and A. Ferrus
Increasing the Number of Synapses Modifies Olfactory Perception in Drosophila
J. Neurosci., August 15, 2001; 21(16): 6264 - 6273.
[Abstract] [Full Text] [PDF]
K. T. N. Ba-Charvet, K. Brose, L. Ma, K. H. Wang, V. Marillat, C. Sotelo, M. Tessier-Lavigne, and A. Chedotal
Diversity and Specificity of Actions of Slit2 Proteolytic Fragments in Axon Guidance
J. Neurosci., June 15, 2001; 21(12): 4281 - 4289.
[Abstract] [Full Text] [PDF]
D. Bagnard, C. Vaillant, S.-T. Khuth, N. Dufay, M. Lohrum, A. W. Puschel, M.-F. Belin, J. Bolz, and N. Thomasset
Semaphorin 3A-Vascular Endothelial Growth Factor-165 Balance Mediates Migration and Apoptosis of Neural Progenitor Cells by the Recruitment of Shared Receptor
J. Neurosci., May 15, 2001; 21(10): 3332 - 3341.
[Abstract] [Full Text] [PDF]
Y Tashiro, M Miyahara, R Shirasaki, M Okabe, C. Heizmann, and F Murakami
Local nonpermissive and oriented permissive cues guide vestibular axons to the cerebellum
Development, January 3, 2001; 128(6): 973 - 981.
[Abstract] [PDF]
E. Brambilla, B. Constantin, H. Drabkin, and J. Roche
Semaphorin SEMA3F Localization in Malignant Human Lung and Cell Lines : A Suggested Role in Cell Adhesion and Cell Migration
Am. J. Pathol., March 1, 2000; 156(3): 939 - 950.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|