 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, June 15, 1999, 19(12):5066-5073
Differential Neural Responses during Performance of Matching and Nonmatching to Sample Tasks at Two Delay Intervals
Rebecca Elliott1 and Raymond J. Dolan1, 2 1 Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom, and 2 Royal Free Hospital School of Medicine, London NW3 2PF, United Kingdom
Visual short-term memory in humans and animals is frequently assessed using delayed matching to sample (DMTS) and delayed nonmatching to sample (DNMTS) tasks across variable delay intervals. Although these tasks depend on certain common mechanisms, there are behavioral differences between them, and neuroimaging provides a means of assessing explicitly whether this is underpinned by differences at a neural level. Findings of delay-dependent deficits, after lesions in humans and animals, suggest that the neural implementation of these tasks may also critically depend on the delay interval. In this study we determined whether there were differential neural responses associated with DMTS and DNMTS tasks at two different delay intervals using functional magnetic resonance imaging. Ten healthy volunteers were studied under four test conditions: DMTS and DNMTS at 5 and 15 sec delay. The main effect of DMTS compared with DNMTS across both delay intervals was associated with significant activation in bilateral head of caudate and medial orbitofrontal cortex. By contrast, DNMTS compared with DMTS was associated with significant activation in mediodorsal thalamus, bilateral lateral orbitofrontal cortex, and left premotor cortex. The main effect of short compared with long delay, across both tasks, was associated with significantly greater activity in occipital and parietal cortices. By contrast, long compared with short delay was associated with significantly greater activity in temporal and ventrolateral frontal cortices. We conclude that DMTS and DNMTS are not equivalent and furthermore that the precise neural implementation of these tasks is a dynamic function of delay interval.
Key words: delayed matching to sample; delayed nonmatching to sample; orbitofrontal cortex; caudate; premotor cortex; medial temporal lobe; functional magnetic resonance imaging
Copyright © 1999 Society for Neuroscience 0270-6474/99/19125066-08$05.00/0
This article has been cited by other articles:
A. Christakou, M. Brammer, V. Giampietro, and K. Rubia
Right Ventromedial and Dorsolateral Prefrontal Cortices Mediate Adaptive Decisions under Ambiguity by Integrating Choice Utility and Outcome Evaluation
J. Neurosci., September 2, 2009; 29(35): 11020 - 11028.
[Abstract] [Full Text] [PDF]
N. D. Walsh and M. L. Phillips
Interacting Outcome Retrieval, Anticipation, and Feedback Processes in the Human Brain
Cereb Cortex, May 8, 2009; (2009) bhp098v1.
[Abstract] [Full Text] [PDF]
G. HERZMANN, V. DANTHIIR, A. SCHACHT, W. SOMMER, and O. WILHELM
Toward a comprehensive test battery for face cognition: Assessment of the tasks
Behav Res Methods, August 1, 2008; 40(3): 840 - 857.
[Abstract] [PDF]
M. L. LoPresti, K. Schon, M. D. Tricarico, J. D. Swisher, K. A. Celone, and C. E. Stern
Working Memory for Social Cues Recruits Orbitofrontal Cortex and Amygdala: A Functional Magnetic Resonance Imaging Study of Delayed Matching to Sample for Emotional Expressions
J. Neurosci., April 2, 2008; 28(14): 3718 - 3728.
[Abstract] [Full Text] [PDF]
R. B. Postuma and A. Dagher
Basal Ganglia Functional Connectivity Based on a Meta-Analysis of 126 Positron Emission Tomography and Functional Magnetic Resonance Imaging Publications
Cereb Cortex, October 1, 2006; 16(10): 1508 - 1521.
[Abstract] [Full Text] [PDF]
K. Schon, A. Atri, M. E. Hasselmo, M. D. Tricarico, M. L. LoPresti, and C. E. Stern
Scopolamine Reduces Persistent Activity Related to Long-Term Encoding in the Parahippocampal Gyrus during Delayed Matching in Humans
J. Neurosci., October 5, 2005; 25(40): 9112 - 9123.
[Abstract] [Full Text] [PDF]
E. Zarahn, B. Rakitin, D. Abela, J. Flynn, and Y. Stern
Positive Evidence against Human Hippocampal Involvement in Working Memory Maintenance of Familiar Stimuli
Cereb Cortex, March 1, 2005; 15(3): 303 - 316.
[Abstract] [Full Text] [PDF]
K. Schon, M. E. Hasselmo, M. L. LoPresti, M. D. Tricarico, and C. E. Stern
Persistence of Parahippocampal Representation in the Absence of Stimulus Input Enhances Long-Term Encoding: A Functional Magnetic Resonance Imaging Study of Subsequent Memory after a Delayed Match-to-Sample Task
J. Neurosci., December 8, 2004; 24(49): 11088 - 11097.
[Abstract] [Full Text] [PDF]
Y. Watanabe and S. Funahashi
Neuronal Activity Throughout the Primate Mediodorsal Nucleus of the Thalamus During Oculomotor Delayed-Responses. I. Cue-, Delay-, and Response-Period Activity
J Neurophysiol, September 1, 2004; 92(3): 1738 - 1755.
[Abstract] [Full Text] [PDF]
S. A. Bunge, I. Kahn, J. D. Wallis, E. K. Miller, and A. D. Wagner
Neural Circuits Subserving the Retrieval and Maintenance of Abstract Rules
J Neurophysiol, November 1, 2003; 90(5): 3419 - 3428.
[Abstract] [Full Text] [PDF]
F. S. Arana, J. A. Parkinson, E. Hinton, A. J. Holland, A. M. Owen, and A. C. Roberts
Dissociable Contributions of the Human Amygdala and Orbitofrontal Cortex to Incentive Motivation and Goal Selection
J. Neurosci., October 22, 2003; 23(29): 9632 - 9638.
[Abstract] [Full Text] [PDF]
M. H.J. Munk, D. E.J. Linden, L. Muckli, H. Lanfermann, F. E. Zanella, W. Singer, and R. Goebel
Distributed Cortical Systems in Visual Short-term Memory Revealed by Event-related Functional Magnetic Resonance Imaging
Cereb Cortex, August 1, 2002; 12(8): 866 - 876.
[Abstract] [Full Text] [PDF]
W. J. Curtis, L. L. Lindeke, M. K. Georgieff, and C. A. Nelson
Neurobehavioural functioning in neonatal intensive care unit graduates in late childhood and early adolescence
Brain, July 1, 2002; 125(7): 1646 - 1659.
[Abstract] [Full Text] [PDF]
G. I. de Zubicaray, K. McMahon, S. J. Wilson, and S. Muthiah
Brain Activity During the Encoding, Retention, and Retrieval of Stimulus Representations
Learn. Mem., September 1, 2001; 8(5): 243 - 251.
[Abstract] [Full Text] [PDF]
C. Pantelis, G. W. Stuart, H. E. Nelson, T. W. Robbins, and T. R.E. Barnes
Spatial Working Memory Deficits in Schizophrenia: Relationship With Tardive Dyskinesia and Negative Symptoms
Am J Psychiatry, August 1, 2001; 158(8): 1276 - 1285.
[Abstract] [Full Text] [PDF]
L. Cornette, P. Dupont, G. Bormans, L. Mortelmans, and G.A. Orban
Separate Neural Correlates for the Mnemonic Components of Successive Discrimination and Working Memory Tasks
Cereb Cortex, January 1, 2001; 11(1): 59 - 72.
[Abstract] [Full Text] [PDF]
A. D. Lawrence, L. H. A. Watkins, B. J. Sahakian, J. R. Hodges, and T. W. Robbins
Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits
Brain, July 1, 2000; 123(7): 1349 - 1364.
[Abstract] [Full Text] [PDF]
R. Elliott, R. J. Dolan, and C. D. Frith
Dissociable Functions in the Medial and Lateral Orbitofrontal Cortex: Evidence from Human Neuroimaging Studies
Cereb Cortex, March 1, 2000; 10(3): 308 - 317.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|