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The Journal of Neuroscience, July 15, 1999, 19(14):5782-5791
-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins
Natalie Ostrerova1, Leonard Petrucelli1, Matthew Farrer2, Nitinkumar Mehta2, Peter Choi1, John Hardy2, and Benjamin Wolozin1 1 Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, and 2 Department of Pharmacology, Mayo Clinic, Jacksonville, Florida 32224
-Synuclein has been implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Mutations in
Key words: 14-3-3 proteins; Alzheimer's disease; apoptosis; BAD; extracellular regulated kinase; Parkinson's disease; protein kinase C; synuclein
Copyright © 1999 Society for Neuroscience 0270-6474/99/19145782-10$05.00/0
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[Abstract] [Full Text] [PDF]
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[Abstract] [Full Text] [PDF]
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[Abstract] [Full Text] [PDF]
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[Abstract] [Full Text] [PDF]
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