 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, August 1, 1999, 19(15):6629-6636
Presynaptic Regulation of Glutamate Release in the Ventral Tegmental Area During Morphine Withdrawal
Olivier J. Manzoni and John T. Williams Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201
The regulation of glutamate (Glu) release from the excitatory input to dopamine cells in the ventral tegmental area (VTA) during acute withdrawal from morphine was studied in slices from animals treated for 6-7 d with morphine. EPSCs were inhibited by opioid agonists acting at µ-subtype receptors but not by selective
- or
-subtype agonists. The opioid inhibition was reduced by 65% with the potassium channel blocker 4-aminopyridine (4-AP; 100 µM) and a 12-lipoxygenase inhibitor, baicalein (5 µM), suggesting that opioids acted via a transduction pathway involving activation of a voltage-dependent potassium conductance by lipoxygenase metabolites as has been shown in the periaqueductal gray (Vaughan et al., 1997). During withdrawal, neither the potency nor the efficacy of D-Ala-Met-enkephalin-Gly-ol (DAMGO) were changed; however, the blockade of µ-opioid inhibition by both 4-AP and baicalein was reduced. In addition, the potency of baclofen to depress EPSCs by GABA-B receptors and the effects of the GABA-uptake inhibitor NO-711 (10 µM) were increased in withdrawn rats. Finally, group 2 (but not group 4 or 1) metabotropic glutamate receptor-mediated presynaptic inhibition was also enhanced in morphine-withdrawn rats. These results suggest that one of the consequences of withdrawal from chronic morphine is an enhanced presynaptic inhibition of the excitatory inputs to the dopamine cells of the VTA. Inhibition of glutamate release during acute withdrawal would add to the inhibition of dopamine cells that is mediated by an augmented release of GABA (Bonci and Williams, 1997).
Key words: ventral tegmental area; opioid; glutamate; GABA; metabotropic receptors; morphine withdrawal
Copyright © 1999 Society for Neuroscience 0270-6474/99/19156629-08$05.00/0
This article has been cited by other articles:
E. B. Margolis, H. L. Fields, G. O. Hjelmstad, and J. M. Mitchell
{delta}-Opioid Receptor Expression in the Ventral Tegmental Area Protects Against Elevated Alcohol Consumption
J. Neurosci., November 26, 2008; 28(48): 12672 - 12681.
[Abstract] [Full Text] [PDF]
H. S Crombag, J. M Bossert, E. Koya, and Y. Shaham
Context-induced relapse to drug seeking: a review
Phil Trans R Soc B, October 12, 2008; 363(1507): 3233 - 3243.
[Abstract] [Full Text] [PDF]
C. P. Ford, M. J. Beckstead, and J. T. Williams
Kappa Opioid Inhibition of Somatodendritic Dopamine Inhibitory Postsynaptic Currents
J Neurophysiol, January 1, 2007; 97(1): 883 - 891.
[Abstract] [Full Text] [PDF]
H. D. Mansvelder
Yin and Yang of VTA Opioid Signaling. Focus on "Both Kappa and Mu Opioid Agonists Inhibit Glutamatergic Input to Ventral Tegmental Area Neurons"
J Neurophysiol, June 1, 2005; 93(6): 3046 - 3047.
[Full Text] [PDF]
E. B. Margolis, G. O. Hjelmstad, A. Bonci, and H. L. Fields
Both Kappa and Mu Opioid Agonists Inhibit Glutamatergic Input to Ventral Tegmental Area Neurons
J Neurophysiol, June 1, 2005; 93(6): 3086 - 3093.
[Abstract] [Full Text] [PDF]
M. Melis, M. Pistis, S. Perra, A. L. Muntoni, G. Pillolla, and G. L. Gessa
Endocannabinoids Mediate Presynaptic Inhibition of Glutamatergic Transmission in Rat Ventral Tegmental Area Dopamine Neurons through Activation of CB1 Receptors
J. Neurosci., January 7, 2004; 24(1): 53 - 62.
[Abstract] [Full Text] [PDF]
S. J. Feinmark, R. Begum, E. Tsvetkov, I. Goussakov, C. D. Funk, S. A. Siegelbaum, and V. Y. Bolshakov
12-Lipoxygenase Metabolites of Arachidonic Acid Mediate Metabotropic Glutamate Receptor-Dependent Long-Term Depression at Hippocampal CA3-CA1 Synapses
J. Neurosci., December 10, 2003; 23(36): 11427 - 11435.
[Abstract] [Full Text] [PDF]
K.-Z. Shen and S. W Johnson
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus
J. Physiol., December 1, 2003; 553(2): 489 - 496.
[Abstract] [Full Text] [PDF]
P. J. Kenny, F. Gasparini, and A. Markou
Group II Metabotropic and {alpha}-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate (AMPA)/Kainate Glutamate Receptors Regulate the Deficit in Brain Reward Function Associated with Nicotine Withdrawal in Rats
J. Pharmacol. Exp. Ther., September 1, 2003; 306(3): 1068 - 1076.
[Abstract] [Full Text] [PDF]
B. Bie and Z. Z. Pan
Presynaptic Mechanism for Anti-Analgesic and Anti-Hyperalgesic Actions of {kappa}-Opioid Receptors
J. Neurosci., August 13, 2003; 23(19): 7262 - 7268.
[Abstract] [Full Text] [PDF]
N.-J. Xu, L. Bao, H.-P. Fan, G.-B. Bao, L. Pu, Y.-J. Lu, C.-F. Wu, X. Zhang, and G. Pei
Morphine Withdrawal Increases Glutamate Uptake and Surface Expression of Glutamate Transporter GLT1 at Hippocampal Synapses
J. Neurosci., June 1, 2003; 23(11): 4775 - 4784.
[Abstract] [Full Text] [PDF]
S. Marinelli, C. W Vaughan, M. J Christie, and M. Connor
Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus In vitro
J. Physiol., September 1, 2002; 543(2): 531 - 540.
[Abstract] [Full Text] [PDF]
D. Robbe, M. Kopf, A. Remaury, J. Bockaert, and O. J. Manzoni
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
PNAS, June 11, 2002; 99(12): 8384 - 8388.
[Abstract] [Full Text] [PDF]
D. Robbe, G. Alonso, S. Chaumont, J. Bockaert, and O. J. Manzoni
Role of P/Q-Ca2+ Channels in Metabotropic Glutamate Receptor 2/3-Dependent Presynaptic Long-Term Depression at Nucleus Accumbens Synapses
J. Neurosci., June 1, 2002; 22(11): 4346 - 4356.
[Abstract] [Full Text] [PDF]
K.-Z. Shen and S. W Johnson
Presynaptic modulation of synaptic transmission by opioid receptor in rat subthalamic nucleus in vitro
J. Physiol., May 15, 2002; 541(1): 219 - 230.
[Abstract] [Full Text] [PDF]
J. M. Harrison, R. G. Allen, M. J. Pellegrino, J. T. Williams, and O. J. Manzoni
Chronic Morphine Treatment Alters Endogenous Opioid Control of Hippocampal Mossy Fiber Synaptic Transmission
J Neurophysiol, May 1, 2002; 87(5): 2464 - 2470.
[Abstract] [Full Text] [PDF]
M. Melis, R. Camarini, M. A. Ungless, and A. Bonci
Long-Lasting Potentiation of GABAergic Synapses in Dopamine Neurons after a Single In Vivo Ethanol Exposure
J. Neurosci., March 15, 2002; 22(6): 2074 - 2082.
[Abstract] [Full Text] [PDF]
P. Congar, A. Bergevin, and L.-E. Trudeau
D2 Receptors Inhibit the Secretory Process Downstream From Calcium Influx in Dopaminergic Neurons: Implication of K+ Channels
J Neurophysiol, February 1, 2002; 87(2): 1046 - 1056.
[Abstract] [Full Text] [PDF]
A. J. Hampson and M. Grimaldi
12-Hydroxyeicosatetrenoate (12-HETE) Attenuates AMPA Receptor-Mediated Neurotoxicity: Evidence for a G-Protein-Coupled HETE Receptor
J. Neurosci., January 1, 2002; 22(1): 257 - 264.
[Abstract] [Full Text] [PDF]
T. Bushell, T. Endoh, A. A. Simen, D. Ren, V. P. Bindokas, and R. J. Miller
Molecular Components of Tolerance to Opiates in Single Hippocampal Neurons
Mol. Pharmacol., January 1, 2002; 61(1): 55 - 64.
[Abstract] [Full Text] [PDF]
D. Robbe, G. Alonso, F. Duchamp, J. Bockaert, and O. J. Manzoni
Localization and Mechanisms of Action of Cannabinoid Receptors at the Glutamatergic Synapses of the Mouse Nucleus Accumbens
J. Neurosci., January 1, 2001; 21(1): 109 - 116.
[Abstract] [Full Text] [PDF]
J. T. Williams, M. J. Christie, and O. Manzoni
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Physiol Rev, January 1, 2001; 81(1): 299 - 343.
[Abstract] [Full Text] [PDF]
A. F. Hoffman and C. R. Lupica
Mechanisms of Cannabinoid Inhibition of GABAA Synaptic Transmission in the Hippocampus
J. Neurosci., April 1, 2000; 20(7): 2470 - 2479.
[Abstract] [Full Text] [PDF]
C. D. Fiorillo and J. T. Williams
Selective Inhibition by Adenosine of mGluR IPSPs in Dopamine Neurons After Cocaine Treatment
J Neurophysiol, March 1, 2000; 83(3): 1307 - 1314.
[Abstract] [Full Text] [PDF]
E. Koga and T. Momiyama
Presynaptic dopamine D2-like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones
J. Physiol., February 15, 2000; 523(1): 163 - 173.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|