 |
 Previous Article | Next Article 
The Journal of Neuroscience, August 15, 1999, 19(16):6818-6824
Hypoxia-Inducible Factor-1 Mediates Hypoxia-Induced Delayed
Neuronal Death That Involves p53
Marc W.
Halterman1, 4,
Craig C.
Miller2, 4, and
Howard J.
Federoff3, 4
Departments of 1 Microbiology and Immunology,
2 Dermatology, and 3 Neurology,
4 Division of Molecular Medicine and Gene Therapy,
University of Rochester School of Medicine and Dentistry, Rochester,
New York 14642
Hypoxia-induced delayed neuronal death is known to require
de novo gene expression; however, the molecular
mediators that are involved remain undefined. The transcription factor
hypoxia-inducible factor-1 (HIF-1), in addition to promoting the
expression of adaptive genes under conditions of hypoxia, has been
implicated as being a necessary component in p53-mediated cell death in
tumors. Using herpes amplicon-mediated gene transfer in cortical
neuronal cultures, we demonstrate that delivery of a dominant-negative form of HIF-1 (HIFdn), capable of disrupting hypoxia-dependent transcription, reduces delayed neuronal death that follows hypoxic stress. In contrast, hypoxia-resistant p53-null primary cultures are
not protected by HIFdn expression. These data indicate that, in hypoxic
neurons, HIF-1 and p53 conspire to promote a pathological sequence
resulting in cell death.
Key words:
HIF-1; p53; hypoxia; neuron; delayed death; stroke
Copyright © 1999 Society for Neuroscience 0270-6474/99/19166818-07$05.00/0
This article has been cited by other articles:
|
|
|
|
 
A. J. Filiano, C. D. C. Bailey, J. Tucholski, S. Gundemir, and G. V. W. Johnson
Transglutaminase 2 protects against ischemic insult, interacts with HIF1{beta}, and attenuates HIF1 signaling
FASEB J,
August 1, 2008;
22(8):
2662 - 2675.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Vangeison, D. Carr, H. J. Federoff, and D. A. Rempe
The Good, the Bad, and the Cell Type-Specific Roles of Hypoxia Inducible Factor-1{alpha} in Neurons and Astrocytes
J. Neurosci.,
February 20, 2008;
28(8):
1988 - 1993.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Rempe, K. M. Lelli, G. Vangeison, R. S. Johnson, and H. J. Federoff
In Cultured Astrocytes, p53 and MDM2 Do Not Alter Hypoxia-inducible Factor-1{alpha} Function Regardless of the Presence of DNA Damage
J. Biol. Chem.,
June 1, 2007;
282(22):
16187 - 16201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Sun, G. He, H. Qing, W. Zhou, F. Dobie, F. Cai, M. Staufenbiel, L. E. Huang, and W. Song
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
PNAS,
December 5, 2006;
103(49):
18727 - 18732.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. W. Calvert, J. Cahill, M. Yamaguchi-Okada, and J. H. Zhang
Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1{alpha} and its downstream target genes
J Appl Physiol,
September 1, 2006;
101(3):
853 - 865.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Helton, J. Cui, J. R. Scheel, J. A. Ellison, C. Ames, C. Gibson, B. Blouw, L. Ouyang, I. Dragatsis, S. Zeitlin, et al.
Brain-Specific Knock-Out of Hypoxia-Inducible Factor-1{alpha} Reduces Rather Than Increases Hypoxic-Ischemic Damage
J. Neurosci.,
April 20, 2005;
25(16):
4099 - 4107.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Xie, R. S. Johnson, and R. S. Freeman
Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1
J. Cell Biol.,
March 14, 2005;
168(6):
911 - 920.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M K S Leow and J Wyckoff
Under-recognised paradox of neuropathy from rapid glycaemic control
Postgrad. Med. J.,
February 1, 2005;
81(952):
103 - 107.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tanaka, Y. Terada, T. Kobayashi, T. Okado, S. Inoshita, M. Kuwahara, A. Seth, Y. Sato, and S. Sasaki
Expression and Function of Ets-1 during Experimental Acute Renal Failure in Rats
J. Am. Soc. Nephrol.,
December 1, 2004;
15(12):
3083 - 3092.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Tezel and X. Yang
Caspase-Independent Component of Retinal Ganglion Cell Death, In Vitro
Invest. Ophthalmol. Vis. Sci.,
November 1, 2004;
45(11):
4049 - 4059.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. R. Ratan, A. Siddiq, L. Aminova, P. S. Lange, B. Langley, I. Ayoub, J. Gensert, and J. Chavez
Translation of Ischemic Preconditioning to the Patient: Prolyl Hydroxylase Inhibition and Hypoxia Inducible Factor-1 as Novel Targets for Stroke Therapy
Stroke,
November 1, 2004;
35(11_suppl_1):
2687 - 2689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Brafman, I. Mett, M. Shafir, H. Gottlieb, G. Damari, S. Gozlan-Kelner, V. Vishnevskia-Dai, R. Skaliter, P. Einat, A. Faerman, et al.
Inhibition of Oxygen-Induced Retinopathy in RTP801-Deficient Mice
Invest. Ophthalmol. Vis. Sci.,
October 1, 2004;
45(10):
3796 - 3805.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A E Greijer and E van der Wall
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
J. Clin. Pathol.,
October 1, 2004;
57(10):
1009 - 1014.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Tezel and M. B. Wax
Hypoxia-Inducible Factor 1{alpha} in the Glaucomatous Retina and Optic Nerve Head
Arch Ophthalmol,
September 1, 2004;
122(9):
1348 - 1356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Acker and H. Acker
Cellular oxygen sensing need in CNS function: physiological and pathological implications
J. Exp. Biol.,
August 15, 2004;
207(18):
3171 - 3188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Fortin, J. G. MacLaurin, N. Arbour, S. P. Cregan, N. Kushwaha, S. M. Callaghan, D. S. Park, P. R. Albert, and R. S. Slack
The Proapoptotic Gene SIVA Is a Direct Transcriptional Target for the Tumor Suppressors p53 and E2F1
J. Biol. Chem.,
July 2, 2004;
279(27):
28706 - 28714.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-J. Lee, J.-Y. Kim, K. Suk, and J.-H. Park
Identification of the Hypoxia-Inducible Factor 1{alpha}-Responsive HGTD-P Gene as a Mediator in the Mitochondrial Apoptotic Pathway
Mol. Cell. Biol.,
May 1, 2004;
24(9):
3918 - 3927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-Y. Kim, H.-J. Ahn, J.-H. Ryu, K. Suk, and J.-H. Park
BH3-only Protein Noxa Is a Mediator of Hypoxic Cell Death Induced by Hypoxia-inducible Factor 1{alpha}
J. Exp. Med.,
January 5, 2004;
199(1):
113 - 124.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Naranjo-Suarez, M. C. Castellanos, M. Alvarez-Tejado, A. Vara, M. O. Landazuri, and L. del Peso
Down-regulation of Hypoxia-inducible Factor-2 in PC12 Cells by Nerve Growth Factor Stimulation
J. Biol. Chem.,
August 22, 2003;
278(34):
31895 - 31901.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Chen, S. Zhao, K. Nakada, Y. Kuge, N. Tamaki, F. Okada, J. Wang, M. Shindo, F. Higashino, K. Takeda, et al.
Dominant-Negative Hypoxia-Inducible Factor-1{alpha} Reduces Tumorigenicity of Pancreatic Cancer Cells through the Suppression of Glucose Metabolism
Am. J. Pathol.,
April 1, 2003;
162(4):
1283 - 1291.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. MacPherson, J. Sage, D. Crowley, A. Trumpp, R. T. Bronson, and T. Jacks
Conditional Mutation of Rb Causes Cell Cycle Defects without Apoptosis in the Central Nervous System
Mol. Cell. Biol.,
February 1, 2003;
23(3):
1044 - 1053.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
N. Gao, B.-H. Jiang, S. S. Leonard, L. Corum, Z. Zhang, J. R. Roberts, J. Antonini, J. Z. Zheng, D. C. Flynn, V. Castranova, et al.
p38 Signaling-mediated Hypoxia-inducible Factor 1alpha and Vascular Endothelial Growth Factor Induction by Cr(VI) in DU145 Human Prostate Carcinoma Cells
J. Biol. Chem.,
November 15, 2002;
277(47):
45041 - 45048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Chavez and J. C. LaManna
Activation of Hypoxia-Inducible Factor-1 in the Rat Cerebral Cortex after Transient Global Ischemia: Potential Role of Insulin-Like Growth Factor-1
J. Neurosci.,
October 15, 2002;
22(20):
8922 - 8931.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. P. Cregan, A. Fortin, J. G. MacLaurin, S. M. Callaghan, F. Cecconi, S.-W. Yu, T. M. Dawson, V. L. Dawson, D. S. Park, G. Kroemer, et al.
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
J. Cell Biol.,
August 5, 2002;
158(3):
507 - 517.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhu, X. O. Mao, Y. Sun, Z. Xia, and D. A. Greenberg
p38 Mitogen-activated Protein Kinase Mediates Hypoxic Regulation of Mdm2 and p53 in Neurons
J. Biol. Chem.,
June 14, 2002;
277(25):
22909 - 22914.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Shoshani, A. Faerman, I. Mett, E. Zelin, T. Tenne, S. Gorodin, Y. Moshel, S. Elbaz, A. Budanov, A. Chajut, et al.
Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, RTP801, Involved in Apoptosis
Mol. Cell. Biol.,
April 1, 2002;
22(7):
2283 - 2293.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Brusselmans, F. Bono, P. Maxwell, Y. Dor, M. Dewerchin, D. Collen, J.-M. Herbert, and P. Carmeliet
Hypoxia-inducible Factor-2alpha (HIF-2alpha ) Is Involved in the Apoptotic Response to Hypoglycemia but Not to Hypoxia
J. Biol. Chem.,
October 12, 2001;
276(42):
39192 - 39196.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. H. DeCory, K. M. Piech-Dumas, S.-S. Sheu, H. J. Federoff, and M. W. Anders
Efflux of Glutathione Conjugate of Monochlorobimane from Striatal and Cortical Neurons
Drug Metab. Dispos.,
October 1, 2001;
29(10):
1256 - 1262.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Bachelder, A. Crago, J. Chung, M. A. Wendt, L. M. Shaw, G. Robinson, and A. M. Mercurio
Vascular Endothelial Growth Factor Is an Autocrine Survival Factor for Neuropilin-expressing Breast Carcinoma Cells
Cancer Res.,
August 1, 2001;
61(15):
5736 - 5740.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Keith, D. M. Adelman, and M. C. Simon
Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt
PNAS,
May 24, 2001;
(2001)
121494298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Chavez, F. Agani, P. Pichiule, and J. C. LaManna
Expression of hypoxia-inducible factor-1alpha in the brain of rats during chronic hypoxia
J Appl Physiol,
November 1, 2000;
89(5):
1937 - 1942.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. L. Semenza
HIF-1 and human disease: one highly involved factor
Genes & Dev.,
August 15, 2000;
14(16):
1983 - 1991.
[Full Text]
|
|
|
|
|
|
|
R. K. Bruick
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
PNAS,
August 1, 2000;
97(16):
9082 - 9087.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Zaman, H. Ryu, D. Hall, K. O'Donovan, K.-I Lin, M. P. Miller, J. C. Marquis, J. M. Baraban, G. L. Semenza, and R. R. Ratan
Protection from Oxidative Stress-Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21waf1/cip1, and Erythropoietin
J. Neurosci.,
November 15, 1999;
19(22):
9821 - 9830.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Hossain, C. M. L. Bouton, J. Pevsner, and J. Laterra
Induction of Vascular Endothelial Growth Factor in Human Astrocytes by Lead. INVOLVEMENT OF A PROTEIN KINASE C/ACTIVATOR PROTEIN-1 COMPLEX-DEPENDENT AND HYPOXIA-INDUCIBLE FACTOR 1-INDEPENDENT SIGNALING PATHWAY
J. Biol. Chem.,
September 1, 2000;
275(36):
27874 - 27882.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Keith, D. M. Adelman, and M. C. Simon
Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt
PNAS,
June 5, 2001;
98(12):
6692 - 6697.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
