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The Journal of Neuroscience, August 15, 1999, 19(16):6818-6824
Hypoxia-Inducible Factor-1 Mediates Hypoxia-Induced Delayed
Neuronal Death That Involves p53
Marc W.
Halterman1, 4,
Craig C.
Miller2, 4, and
Howard J.
Federoff3, 4
Departments of 1 Microbiology and Immunology,
2 Dermatology, and 3 Neurology,
4 Division of Molecular Medicine and Gene Therapy,
University of Rochester School of Medicine and Dentistry, Rochester,
New York 14642
Hypoxia-induced delayed neuronal death is known to require
de novo gene expression; however, the molecular
mediators that are involved remain undefined. The transcription factor
hypoxia-inducible factor-1 (HIF-1), in addition to promoting the
expression of adaptive genes under conditions of hypoxia, has been
implicated as being a necessary component in p53-mediated cell death in
tumors. Using herpes amplicon-mediated gene transfer in cortical
neuronal cultures, we demonstrate that delivery of a dominant-negative form of HIF-1 (HIFdn), capable of disrupting hypoxia-dependent transcription, reduces delayed neuronal death that follows hypoxic stress. In contrast, hypoxia-resistant p53-null primary cultures are
not protected by HIFdn expression. These data indicate that, in hypoxic
neurons, HIF-1 and p53 conspire to promote a pathological sequence
resulting in cell death.
Key words:
HIF-1; p53; hypoxia; neuron; delayed death; stroke
Copyright © 1999 Society for Neuroscience 0270-6474/99/19166818-07$05.00/0
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