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The Journal of Neuroscience, August 15, 1999, 19(16):6907-6917
Embryonic Lethal Abnormal Vision-Like RNA-Binding Proteins Regulate Neurite Outgrowth and Tau Expression in PC12 Cells
Gonzalo E. Aranda-Abreu1, Leah Behar1, Sangmi Chung2, Henry Furneaux2, and Irith Ginzburg1 1 Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel, and 2 Program in Molecular Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021
The embryonic lethal abnormal vision (ELAV)-like proteins are mRNA-binding proteins that regulate mRNA stability. The neuronal members of this family are required for neuronal differentiation. We identified the binding region of purified HuD protein to a target neuronal mRNA encoding for the tau microtubule-associated protein and demonstrated an in vivo interaction between the ELAV-like protein and its target tau mRNA. We show that treatment of neuronal cells with antisense oligodeoxynucleotides directed against HuD blocks the induction of neurite outgrowth and decreases the levels of tau mRNAs, indicating that the ELAV-like proteins are required for neuronal differentiation.
Key words: RNA-binding proteins; tau mRNA; mRNA stabilization; neurite outgrowth; antisense oligodeoxynucleotides; microtubules
Copyright © 1999 Society for Neuroscience 0270-6474/99/19166907-11$05.00/0
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