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The Journal of Neuroscience, August 15, 1999, 19(16):7182-7190
Effect of Intraduodenal Lipid on Parabrachial Gustatory Coding in
Awake Rats
Andras
Hajnal,
Kaoru
Takenouchi, and
Ralph
Norgren
Department of Behavioral Science, College of Medicine, The
Pennsylvania State University, Hershey, Pennsylvania 17033
Intestinal fat differentially suppresses sham feeding of liquid
diets and preferred gustatory stimuli. Although the behavioral effect
is robust, no electrophysiological evidence exists to account for its
neural basis. Therefore, we investigated the effect of intestinal fat
on gustatory coding in the pontine parabrachial nuclei (PBN) by
recording from single neurons in awake rats before, during, and after
intraduodenal infusions of lipid (Intralipid; 10 ml, 5 kcal).
Intraduodenal lipid did not alter the response profiles of PBN taste
neurons. It did, however, produce an overall decrease in response
magnitude ( 16.25%; n = 43), with the largest reduction to sucrose (30%; n = 43). The most
pronounced suppression occurred in sucrose-best neurons in response to
sucrose (55%; n = 19), and this effect was
largest for the sucrose-specific cells (77%; n = 3). After lipid infusions, nonspecific neurons in both the sucrose-best
and NaCl-best categories also responded less to their best stimulus
(sucrose, 46%; n = 16; NaCl, 35%; n = 13). In contrast, no significant changes were
found in NaCl-specific cells in response to NaCl. All effects appeared
with short latency (~5 min) and were reversible within the time frame
of a meal. In controls, duodenal infusions of saline did not cause any
changes in taste responsiveness. These results suggest that intestinal fat has specific effects on taste coding in the PBN that may contribute to the intake suppression of palatable food observed in behavioral studies. The similar, short latency of both the behavioral and neural
effects supports the hypothesis of a preabsorptive site of action.
Key words:
gustatory coding; sucrose; sodium; lipid; duodenum; postprandial satiety; single-unit recording; pontine parabrachial
nucleus; rats
Copyright © 1999 Society for Neuroscience 0270-6474/99/19167182-09$05.00/0
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