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The Journal of Neuroscience, September 1, 1999, 19(17):7568-7577

Mechanisms of Induction and Expression of Long-Term Depression at GABAergic Synapses in the Neonatal Rat Hippocampus

Olivier Caillard, Yehezkel Ben-Ari, and Jean-Luc Gaïarsa

Institut de Neurobiologie de la Mediterranée (INMED), Institut National de la Santé et de la Recherche Médicale U29, B.P. 13, 13273 Marseille Cedex 09, France

Synaptic plasticity at excitatory glutamatergic synapses is believed to be instrumental in the maturation of neuronal networks. Using whole-cell patch-clamp recordings, we have studied the mechanisms of induction and expression of long-term depression at excitatory GABAergic synapses in the neonatal rat hippocampus (LTDGABA-A). We report that the induction of LTDGABA-A requires a GABAA receptor-mediated membrane depolarization, which is necessary to remove the Mg2+ block from postsynaptic NMDA receptors. LTDGABA-A is associated with an increase in the coefficient of variation of evoked GABAA receptor-mediated synaptic currents and a decrease in the frequency, but not amplitude, of Sr2+-induced asynchronous GABAA quantal events. We conclude that LTDGABA-A induction requires the activation of both GABAA and NMDA postsynaptic receptors and that its expression is likely presynaptic.

Key words: synaptic plasticity; development; GABA; glutamate; calcium; hippocampus

Copyright © 1999 Society for Neuroscience  0270-6474/99/19177568-10$05.00/0


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