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The Journal of Neuroscience, September 15, 1999, 19(18):7991-7998

Rescue of Cerebellar Granule Cells from Death in weaver NR1 Double Mutants

Patricia Jensen¹, D. James Surmeier², and Dan Goldowitz¹

¹ Center for Neuroscience, University of Tennessee Memphis, Memphis, Tennessee 38163, and ² Department of Physiology/Northwestern University Institute for Neuroscience, Northwestern University, Chicago, Illinois 60611

The weaver mutation results in the extensive death of midline cerebellar granule cells. The mutation consists of a single base pair substitution of the gene encoding the G-protein-activated inwardly rectifying potassium channel protein, GIRK2. The functional consequences of this mutation are still in dispute. In this study we demonstrate the in vivo and in vitro rescue of weaver granule cells when NR1 NMDA subunits are eliminated in weaver NR1 double mutants. This rescue of weaver granule cells provides evidence that wvGIRK2 alone is not sufficient to cause granule cell death.

Key words: weaver; GIRK2; granule cell development; cerebellum; NMDA receptor; cell death

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Copyright © 1999 Society for Neuroscience  0270-6474/99/19187991-08$05.00/0

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