QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (33) Citing Articles via Google Scholar Google Scholar Articles by Corriveau, R. A. Articles by Nedivi, E. Search for Related Content PubMed PubMed Citation Articles by Corriveau, R. A. Articles by Nedivi, E.

 Previous Article  |  Next Article 

The Journal of Neuroscience, September 15, 1999, 19(18):7999-8008

Dynamic Regulation of cpg15 during Activity-Dependent Synaptic Development in the Mammalian Visual System

Roderick A. Corriveau¹, Carla J. Shatz¹, and Elly Nedivi²

¹ Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, and ² Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

During visual system development, neural activity regulates structural changes in connectivity including axonal branching and dendritic growth. Here we have examined a role for the candidate plasticity gene 15 (cpg15), which encodes an activity-regulated molecule that can promote dendritic growth, in this process. We report that cpg15 is expressed in the cat visual system at relatively high levels in the lateral geniculate nucleus (LGN) but at very low levels in its synaptic target, layer 4 of the visual cortex. Prenatally, when cpg15 mRNA in the LGN is most abundant, expression is insensitive to action potential blockade by tetrodotoxin. Postnatally, activity regulation of cpg15 emerges in the LGN coincident with development of ocular dominance columns in the visual cortex. cpg15 can be detected in layers 2/3 and 5/6 of visual cortex postnatally, and expression in layers 2/3 is activity-regulated during known periods of activity-dependent plasticity for these layers. Localization and regulation of cpg15 expression in the visual system are consistent with a presynaptic role for CPG15 in shaping dendritic arbors of target neurons during activity-dependent synaptic rearrangements, both in development and adulthood.

Key words: visual system; cpg15; lateral geniculate nucleus; dendritic growth; visual cortex; neuron

---

Copyright © 1999 Society for Neuroscience  0270-6474/99/19187999-10$05.00/0

This article has been cited by other articles:

				S. Loebrich and E. Nedivi The Function of Activity-Regulated Genes in the Nervous System Physiol Rev, October 1, 2009; 89(4): 1079 - 1103. [Abstract] [Full Text] [PDF]

				E. I. Knudsen, J. J. Heckman, J. L. Cameron, and J. P. Shonkoff Economic, neurobiological, and behavioral perspectives on building America's future workforce PNAS, July 5, 2006; 103(27): 10155 - 10162. [Abstract] [Full Text] [PDF]

				C. B. Yang, Y. T. Zheng, G. Y. Li, and G. D. Mower Identification of Munc13-3 as a Candidate Gene for Critical-Period Neuroplasticity in Visual Cortex J. Neurosci., October 1, 2002; 22(19): 8614 - 8618. [Abstract] [Full Text] [PDF]

				W.-C. A. Lee and E. Nedivi Extended Plasticity of Visual Cortex in Dark-Reared Animals May Result from Prolonged Expression of cpg15-Like Genes J. Neurosci., March 1, 2002; 22(5): 1807 - 1815. [Abstract] [Full Text] [PDF]

				N. Mataga, S. Fujishima, B. G. Condie, and T. K. Hensch Experience-Dependent Plasticity of Mouse Visual Cortex in the Absence of the Neuronal Activity-Dependent Marker egr1/zif268 J. Neurosci., December 15, 2001; 21(24): 9724 - 9732. [Abstract] [Full Text] [PDF]

				L. Morando, R. Cesa, R. Rasetti, R. Harvey, and P. Strata Role of glutamate delta -2 receptors in activity-dependent competition between heterologous afferent fibers PNAS, August 1, 2001; (2001) 171098398. [Abstract] [Full Text] [PDF]

				A. K. McAllister Cellular and Molecular Mechanisms of Dendrite Growth Cereb Cortex, October 1, 2000; 10(10): 963 - 973. [Abstract] [Full Text] [PDF]

				S. U. Walkley, M. Zervas, and S. Wiseman Gangliosides as Modulators of Dendritogenesis in Normal and Storage Disease-affected Pyramidal Neurons Cereb Cortex, October 1, 2000; 10(10): 1028 - 1037. [Abstract] [Full Text] [PDF]

				A. L. Barth, M. McKenna, S. Glazewski, P. Hill, S. Impey, D. Storm, and K. Fox Upregulation of cAMP Response Element-Mediated Gene Expression during Experience-Dependent Plasticity in Adult Neocortex J. Neurosci., June 1, 2000; 20(11): 4206 - 4216. [Abstract] [Full Text] [PDF]

				N. Sugiura, R. G. Patel, and R. A. Corriveau N-Methyl-D-aspartate Receptors Regulate a Group of Transiently Expressed Genes in the Developing Brain J. Biol. Chem., April 20, 2001; 276(17): 14257 - 14263. [Abstract] [Full Text] [PDF]

				L. Morando, R. Cesa, R. Rasetti, R. Harvey, and P. Strata Role of glutamate delta -2 receptors in activity-dependent competition between heterologous afferent fibers PNAS, August 14, 2001; 98(17): 9954 - 9959. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help