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The Journal of Neuroscience, October 1, 1999, 19(19):8172-8181
Serotonin Enhances Central Olfactory Neuron Responses to Female Sex Pheromone in the Male Sphinx Moth Manduca sexta
Peter Kloppenburg1, 2, Donald Ferns3, and Alison R. Mercer2, 3 1 Section of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, 2 Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721, and 3 Centre for Neuroscience and Department of Zoology, University of Otago, Dunedin, New Zealand
In the brain of the sphinx moth Manduca sexta, sex-pheromonal information is processed in a prominent male-specific area of the antennal lobe called the macroglomerular complex (MGC). Whole-cell patch-clamp recordings from identified projection (output) neurons in the MGC have shown that serotonin [5-hydroxytryptamine (5-HT)] increases both the excitability of MGC projection neurons and their responses to stimulation with pheromone. At least two types of voltage-activated potassium currents in these cells are modulated by 5-HT. 5-HT decreases the maximal conductance of a transient potassium current (IA) and shifts its voltage for half-maximal inactivation to more negative potentials without affecting the half-maximal voltage for activation. This reduces the "window current" between the voltage activation and inactivation curves, decreasing the tonically active IA near the resting potential and causing the cell to depolarize. 5-HT's effect in this case is to decrease both the transient and resting K+ conductance by modulating the same channel (IA). 5-HT also decreases the maximal conductance of a sustained potassium current [IK(V)] without affecting its voltage dependence. Using HPLC, we show also that levels of 5-HT in the antennal lobes fluctuate significantly over a 24 hr period. Interestingly, 5-HT levels are highest at times when the moths are most active. We suggest that by controlling the responsiveness of antennal-lobe projection neurons to olfactory stimuli, 5-HT will have significant impact on the performance of odor-dependent behaviors.
Key words: olfaction; pheromone; neuromodulation; serotonin; K+ currents; glomeruli
Copyright © 1999 Society for Neuroscience 0270-6474/99/19198172-10$05.00/0
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