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The Journal of Neuroscience, October 1, 1999, 19(19):8271-8280

NMDA-Induced Dendritic Oscillations during a Soma Voltage Clamp of Chick Spinal Neurons

L. E. Moore¹, N. Chub², J. Tabak², and M. O'Donovan²

¹ Laboratoire de Neurobiologie des Reseaux Sensorimoteurs, UPRESA-7060, Paris, France, and ² Laboratory of Neural Control, National Institutes of Health, Bethesda, Maryland 20892

An investigation of dendritic membrane properties was performed by whole-cell patch measurements of the biophysical properties of intact chick spinal neurons that are involved in rhythmogenesis. A whole-cell voltage clamp of the somatic membrane was used to block NMDA-induced voltage oscillations from the cell body, thus partially isolating the intrinsic oscillatory properties of dendritic membranes from those of the soma. An experimental approach was developed that takes into account the complexity of the dendritic tree in an environment as normal as possible, without the need for cell isolation or slice preparations. A computational study of the experimentally determined model showed that excitatory amino acid receptors on dendrites can dynamically control the electrotonic length of the dendrites through the activation of negative slope conductances. These experiments demonstrate the presence of NMDA receptors on the dendrites and that they induce intrinsic oscillations when the synaptic input from other cells is significantly reduced.

Key words: dendritic oscillations; chick spinal neurons; NMDA; electrotonic structure; frequency domain; impedance

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Copyright © 1999 Society for Neuroscience  0270-6474/99/19198271-10$05.00/0

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