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Previous Article | Next Article
The Journal of Neuroscience, October 1, 1999, 19(19):8454-8463
The Neuronal Architecture of Xenopus Retinal Ganglion Cells Is Sculpted by Rho-Family GTPases In Vivo
Maureen L. Ruchhoeft1, Shin-ichi Ohnuma2, Lisa McNeill1, 3, Christine E. Holt2, and William A. Harris2 1 Biology Department, University of California at San Diego, La Jolla, California 92093-0357, 2 Department of Anatomy, Cambridge University, Cambridge, CB2 3DY, United Kingdom, and 3 Xcyte Therapies, Seattle, Washington 98134
Dendritogenesis, axonogenesis, pathfinding, and target recognition are all affected in distinct ways when Xenopus retinal ganglion cells (RGCs) are transfected with constitutively active (ca), wild-type (wt), and dominant negative (dn) Rho-family GTPases in vivo. Dendritogenesis required Rac1 and Cdc42 activity. Moreover, ca-Rac1 caused dendrite hyperproliferation. Axonogenesis, in contrast, was inhibited by ca-Rac1. This phenotype was partially rescued by the coexpression of dn cyclin-dependent kinase (Cdk5), a proposed effector of Rac1, suggesting that Rac1 activity must be regulated tightly for normal axonogenesis. Growth cone morphology was particularly sensitive to dn-RhoA and wt-Cdc42 constructs. These also caused targeting errors, such as tectal bypass, suggesting that cytoskeletal rearrangements are involved in target recognition and are transduced by these pathways.
Key words: RhoA; Rac1; Cdc42; axonogenesis; dendritogenesis; GTPase
Copyright © 1999 Society for Neuroscience 0270-6474/99/19198454-10$05.00/0
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