 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, October 1, 1999, 19(19):8464-8475
Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes
Luke Y. S. Oh1, Peter H. Larsen1, Craig A. Krekoski2, Dylan R. Edwards2, Frances Donovan3, Zena Werb3, and V. Wee Yong1 1 Departments of Oncology and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada T2N 4N1, 2 School of Biological Sciences, University of East Anglia, Norwich, United Kingdom, and 3 Department of Anatomy, University of California, San Francisco, San Francisco, California 94143-0452
Oligodendrocytes (OLs) extend processes to contact axons as a prerequisite step in myelin formation. As the OL processes migrate toward their axonal targets, they modify adhesion to their substrate, an event that may be regulated by matrix metalloproteinases (MMPs). In the mouse optic nerve, MMP-9/gelatinase B increases during myelin formation. Although tissue inhibitor of metalloproteinase (TIMP)-3 also increases in parallel, the developing optic nerve has focally active MMPs demonstrable by in situ zymography. The distribution of proteolytic activity is similar to that of myelin basic protein, a marker of myelin formation. OLs in culture secrete MMP-9 and express active cell-associated metalloproteinases at the growing tips of their processes. TIMP-1 and a function-perturbing anti-MMP-9 antibody attenuate outgrowth of processes by OLs, indicating a requirement for MMP-9 in process outgrowth. Process reformation is retarded significantly in OLs cultured from MMP-9 null mice, as compared with controls, providing genetic evidence that MMP-9 is necessary for process outgrowth. These data show that MMP-9 facilitates process outgrowth by OLs in vivo and in culture.
Key words: myelination; oligodendrocyte; matrix metalloproteinase; in situ zymography; MMP knock-out; TIMPs
Copyright © 1999 Society for Neuroscience 0270-6474/99/19198464-12$05.00/0
This article has been cited by other articles:
G. M. Wilczynski, F. A. Konopacki, E. Wilczek, Z. Lasiecka, A. Gorlewicz, P. Michaluk, M. Wawrzyniak, M. Malinowska, P. Okulski, L. R. Kolodziej, et al.
Important role of matrix metalloproteinase 9 in epileptogenesis
J. Cell Biol., March 5, 2008; 180(5): 1021 - 1035.
[Abstract] [Full Text] [PDF]
O. Bozdagi, V. Nagy, K. T. Kwei, and G. W. Huntley
In Vivo Roles for Matrix Metalloproteinase-9 in Mature Hippocampal Synaptic Physiology and Plasticity
J Neurophysiol, July 1, 2007; 98(1): 334 - 344.
[Abstract] [Full Text] [PDF]
B Gonthier, C Nasarre, L Roth, M Perraut, N Thomasset, G Roussel, D Aunis, and D Bagnard
Functional Interaction between Matrix Metalloproteinase-3 and Semaphorin-3C during Cortical Axonal Growth and Guidance
Cereb Cortex, July 1, 2007; 17(7): 1712 - 1721.
[Abstract] [Full Text] [PDF]
R. Milner, S. J. Crocker, S. Hung, X. Wang, R. F. Frausto, and G. J. del Zoppo
Fibronectin- and Vitronectin-Induced Microglial Activation and Matrix Metalloproteinase-9 Expression Is Mediated by Integrins {alpha}5beta1 and {alpha}vbeta5
J. Immunol., June 15, 2007; 178(12): 8158 - 8167.
[Abstract] [Full Text] [PDF]
T. Suzuki, M. Mandai, M. Akimoto, N. Yoshimura, and M. Takahashi
The Simultaneous Treatment of MMP-2 Stimulants in Retinal Transplantation Enhances Grafted Cell Migration into the Host Retina
Stem Cells, November 1, 2006; 24(11): 2406 - 2411.
[Abstract] [Full Text] [PDF]
F.-E Mo and L. F. Lau
The Matricellular Protein CCN1 Is Essential for Cardiac Development
Circ. Res., October 27, 2006; 99(9): 961 - 969.
[Abstract] [Full Text] [PDF]
M. Xue, M. D. Hollenberg, and V. Wee Yong
Combination of Thrombin and Matrix Metalloproteinase-9 Exacerbates Neurotoxicity in Cell Culture and Intracerebral Hemorrhage in Mice
J. Neurosci., October 4, 2006; 26(40): 10281 - 10291.
[Abstract] [Full Text] [PDF]
M. M. Choe, P. H. S. Sporn, and M. A. Swartz
Extracellular Matrix Remodeling by Dynamic Strain in a Three-Dimensional Tissue-Engineered Human Airway Wall Model
Am. J. Respir. Cell Mol. Biol., September 1, 2006; 35(3): 306 - 313.
[Abstract] [Full Text] [PDF]
J. L. Johnson, A. H. Baker, K. Oka, L. Chan, A. C. Newby, C. L. Jackson, and S. J. George
Suppression of Atherosclerotic Plaque Progression and Instability by Tissue Inhibitor of Metalloproteinase-2: Involvement of Macrophage Migration and Apoptosis
Circulation, May 23, 2006; 113(20): 2435 - 2444.
[Abstract] [Full Text] [PDF]
S. Agrawal, P. Anderson, M. Durbeej, N. van Rooijen, F. Ivars, G. Opdenakker, and L. M. Sorokin
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
J. Exp. Med., April 17, 2006; 203(4): 1007 - 1019.
[Abstract] [Full Text] [PDF]
F. Mannello, G. A.M. Tonti, G. P. Bagnara, and S. Papa
Role and Function of Matrix Metalloproteinases in the Differentiation and Biological Characterization of Mesenchymal Stem Cells
Stem Cells, March 1, 2006; 24(3): 475 - 481.
[Abstract] [Full Text] [PDF]
P. H. Larsen, A. G. DaSilva, K. Conant, and V. W. Yong
Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.
J. Neurosci., February 22, 2006; 26(8): 2207 - 2214.
[Abstract] [Full Text] [PDF]
F. Noorbakhsh, S. Tsutsui, N. Vergnolle, L. A. Boven, N. Shariat, M. Vodjgani, K. G. Warren, P. Andrade-Gordon, M. D. Hollenberg, and C. Power
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis
J. Exp. Med., February 21, 2006; 203(2): 425 - 435.
[Abstract] [Full Text] [PDF]
V. Nagy, O. Bozdagi, A. Matynia, M. Balcerzyk, P. Okulski, J. Dzwonek, R. M. Costa, A. J. Silva, L. Kaczmarek, and G. W. Huntley
Matrix Metalloproteinase-9 Is Required for Hippocampal Late-Phase Long-Term Potentiation and Memory
J. Neurosci., February 15, 2006; 26(7): 1923 - 1934.
[Abstract] [Full Text] [PDF]
M. Wang, J. Zhang, G. Spinetti, L.-Q. Jiang, R. Monticone, D. Zhao, L. Cheng, M. Krawczyk, M. Talan, G. Pintus, et al.
Angiotensin II Activates Matrix Metalloproteinase Type II and Mimics Age-Associated Carotid Arterial Remodeling in Young Rats
Am. J. Pathol., November 1, 2005; 167(5): 1429 - 1442.
[Abstract] [Full Text] [PDF]
J. Lee, M. Gravel, R. Zhang, P. Thibault, and P. E. Braun
Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein
J. Cell Biol., August 15, 2005; 170(4): 661 - 673.
[Abstract] [Full Text] [PDF]
A. Orlandi, A. Ciucci, A. Ferlosio, A. Pellegrino, L. Chiariello, and L. G. Spagnoli
Increased Expression and Activity of Matrix Metalloproteinases Characterize Embolic Cardiac Myxomas
Am. J. Pathol., June 1, 2005; 166(6): 1619 - 1628.
[Abstract] [Full Text] [PDF]
H. Toft-Hansen, R. K. Nuttall, D. R. Edwards, and T. Owens
Key Metalloproteinases Are Expressed by Specific Cell Types in Experimental Autoimmune Encephalomyelitis
J. Immunol., October 15, 2004; 173(8): 5209 - 5218.
[Abstract] [Full Text] [PDF]
P. H. Larsen and V. W. Yong
The Expression of Matrix Metalloproteinase-12 by Oligodendrocytes Regulates Their Maturation and Morphological Differentiation
J. Neurosci., September 1, 2004; 24(35): 7597 - 7603.
[Abstract] [Full Text] [PDF]
W. M. Frederiks and O. R.F. Mook
Metabolic Mapping of Proteinase Activity with Emphasis on In Situ Zymography of Gelatinases: Review and Protocols
J. Histochem. Cytochem., June 1, 2004; 52(6): 711 - 722.
[Abstract] [Full Text] [PDF]
S. Tsutsui, J. Schnermann, F. Noorbakhsh, S. Henry, V. W. Yong, B. W. Winston, K. Warren, and C. Power
A1 Adenosine Receptor Upregulation and Activation Attenuates Neuroinflammation and Demyelination in a Model of Multiple Sclerosis
J. Neurosci., February 11, 2004; 24(6): 1521 - 1529.
[Abstract] [Full Text] [PDF]
S.-R. Lee, K. Tsuji, S.-R. Lee, and E. H. Lo
Role of Matrix Metalloproteinases in Delayed Neuronal Damage after Transient Global Cerebral Ischemia
J. Neurosci., January 21, 2004; 24(3): 671 - 678.
[Abstract] [Full Text] [PDF]
P. H. Larsen, J. E. Wells, W. B. Stallcup, G. Opdenakker, and V. W. Yong
Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan
J. Neurosci., December 3, 2003; 23(35): 11127 - 11135.
[Abstract] [Full Text] [PDF]
J. E. A. Wells, T. K. Rice, R. K. Nuttall, D. R. Edwards, H. Zekki, S. Rivest, and V. W. Yong
An Adverse Role for Matrix Metalloproteinase 12 after Spinal Cord Injury in Mice
J. Neurosci., November 5, 2003; 23(31): 10107 - 10115.
[Abstract] [Full Text] [PDF]
O. R.F. Mook, C. Van Overbeek, E. G. Ackema, F. Van Maldegem, and W. M. Frederiks
In Situ Localization of Gelatinolytic Activity in the Extracellular Matrix of Metastases of Colon Cancer in Rat Liver Using Quenched Fluorogenic DQ-gelatin
J. Histochem. Cytochem., June 1, 2003; 51(6): 821 - 829.
[Abstract] [Full Text] [PDF]
K. C. Boardman and M. A. Swartz
Interstitial Flow as a Guide for Lymphangiogenesis
Circ. Res., April 18, 2003; 92(7): 801 - 808.
[Abstract] [Full Text] [PDF]
J. Deshane, C. C. Garner, and H. Sontheimer
Chlorotoxin Inhibits Glioma Cell Invasion via Matrix Metalloproteinase-2
J. Biol. Chem., January 31, 2003; 278(6): 4135 - 4144.
[Abstract] [Full Text] [PDF]
M. M. Belcheva, P. D. Haas, Y. Tan, V. M. Heaton, and C. J. Coscia
The Fibroblast Growth Factor Receptor Is at the Site of Convergence between {micro}-Opioid Receptor and Growth Factor Signaling Pathways in Rat C6 Glioma Cells
J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 909 - 918.
[Abstract] [Full Text] [PDF]
C. A. Krekoski, D. Neubauer, J. B. Graham, and D. Muir
Metalloproteinase-Dependent Predegeneration In Vitro Enhances Axonal Regeneration within Acellular Peripheral Nerve Grafts
J. Neurosci., December 1, 2002; 22(23): 10408 - 10415.
[Abstract] [Full Text] [PDF]
S. K. Chintala, X. Zhang, J. S. Austin, and M. E. Fini
Deficiency in Matrix Metalloproteinase Gelatinase B (MMP-9) Protects against Retinal Ganglion Cell Death after Optic Nerve Ligation
J. Biol. Chem., November 27, 2002; 277(49): 47461 - 47468.
[Abstract] [Full Text] [PDF]
V. V. Artym, A. L. Kindzelskii, W.-T. Chen, and H. R. Petty
Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on {beta}1 integrins and the cytoskeleton
Carcinogenesis, October 1, 2002; 23(10): 1593 - 1602.
[Abstract] [Full Text] [PDF]
L. J. Noble, F. Donovan, T. Igarashi, S. Goussev, and Z. Werb
Matrix Metalloproteinases Limit Functional Recovery after Spinal Cord Injury by Modulation of Early Vascular Events
J. Neurosci., September 1, 2002; 22(17): 7526 - 7535.
[Abstract] [Full Text] [PDF]
E. Llano, G. Adam, A. M. Pendas, V. Quesada, L. M. Sanchez, I. Santamaria, S. Noselli, and C. Lopez-Otin
Structural and Enzymatic Characterization of Drosophila Dm2-MMP, a Membrane-bound Matrix Metalloproteinase with Tissue-specific Expression
J. Biol. Chem., June 21, 2002; 277(26): 23321 - 23329.
[Abstract] [Full Text] [PDF]
V. Brundula, N. B. Rewcastle, L. M. Metz, C. C. Bernard, and V. W. Yong
Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis
Brain, June 1, 2002; 125(6): 1297 - 1308.
[Abstract] [Full Text] [PDF]
J. L. Arbiser, J. Petros, R. Klafter, B. Govindajaran, E. R. McLaughlin, L. F. Brown, C. Cohen, M. Moses, S. Kilroy, R. S. Arnold, et al.
Reactive oxygen generated by Nox1 triggers the angiogenic switch
PNAS, January 22, 2002; 99(2): 715 - 720.
[Abstract] [Full Text] [PDF]
H. Hayashita-Kinoh, H. Kinoh, A. Okada, K. Komori, Y. Itoh, T. Chiba, M. Kajita, I. Yana, and M. Seiki
Membrane-Type 5 Matrix Metalloproteinase Is Expressed in Differentiated Neurons and Regulates Axonal Growth
Cell Growth Differ., November 1, 2001; 12(11): 573 - 580.
[Abstract] [Full Text] [PDF]
M. Asahi, X. Wang, T. Mori, T. Sumii, J.-C. Jung, M. A. Moskowitz, M. E. Fini, and E. H. Lo
Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood-Brain Barrier and White Matter Components after Cerebral Ischemia
J. Neurosci., October 1, 2001; 21(19): 7724 - 7732.
[Abstract] [Full Text] [PDF]
B. C. Kieseier, C. Schneider, J. M. Clements, A. J. H. Gearing, R. Gold, K. V. Toyka, and H.-P. Hartung
Expression of specific matrix metalloproteinases in inflammatory myopathies
Brain, February 1, 2001; 124(2): 341 - 351.
[Abstract] [Full Text] [PDF]
X. Wang, J. Jung, M. Asahi, W. Chwang, L. Russo, M. A. Moskowitz, C. E. Dixon, M. E. Fini, and E. H. Lo
Effects of Matrix Metalloproteinase-9 Gene Knock-Out on Morphological and Motor Outcomes after Traumatic Brain Injury
J. Neurosci., September 15, 2000; 20(18): 7037 - 7042.
[Abstract] [Full Text] [PDF]
T. H. Vu and Z. Werb
Matrix metalloproteinases: effectors of development and normal physiology
Genes & Dev., September 1, 2000; 14(17): 2123 - 2133.
[Full Text]
J. B. Johnston, Y. Jiang, G. van Marle, M. B. Mayne, W. Ni, J. Holden, J. C. McArthur, and C. Power
Lentivirus Infection in the Brain Induces Matrix Metalloproteinase Expression: Role of Envelope Diversity
J. Virol., August 15, 2000; 74(16): 7211 - 7220.
[Abstract] [Full Text]
A. Pagenstecher, A. K. Stalder, C. L. Kincaid, B. Volk, and I. L. Campbell
Regulation of Matrix Metalloproteinases and Their Inhibitor Genes in Lipopolysaccharide-Induced Endotoxemia in Mice
Am. J. Pathol., July 1, 2000; 157(1): 197 - 210.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|