 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, October 1, 1999, 19(19):8623-8629
Cortical Involvement in the Induction, But Not Expression, of Thalamic Plasticity
Jayson L. Parker and Jonathan O. Dostrovsky University of Toronto, Department of Physiology, Toronto, Ontario M5S 1A8, Canada
The present study examined the role of the somatosensory cortex in the plasticity of thalamic sensory maps. Thalamic plasticity was induced by the disruption of hindlimb input by unilateral destruction of nucleus gracilis. Unilateral somatosensory cortex lesions were performed either on the same day as or a week after the removal of hindlimb input. Multiple electrode penetrations enabled us to measure the volume of somatosensory thalamus devoted to hindlimb, forepaw, and shoulder body regions.
Cortical lesions alone did not change the volume of the shoulder, forepaw, or hindlimb representations in the thalamus relative to controls. However, these lesions blocked the increase in shoulder representation resulting from the nucleus gracilis lesion. In contrast, if thalamic reorganization caused by removal of hindlimb input was allowed to occur, subsequent somatosensory cortex lesions 1 week later did not prevent reorganization. Thus, an intact somatosensory cortex is necessary for the occurrence of sensory map reorganization at the thalamic level (induction) in response to nucleus gracilis lesions, but not for the maintenance of such changes once they are present (expression).
Key words: VPL; thalamus; nucleus gracilis; somatosensory cortex; plasticity; induction; expression; deafferentation
Copyright © 1999 Society for Neuroscience 0270-6474/99/19198623-07$05.00/0
This article has been cited by other articles:
S. A. Chowdhury, K. A. Greek, and D. D. Rasmusson
Changes in corticothalamic modulation of receptive fields during peripheral injury-induced reorganization
PNAS, May 4, 2004; 101(18): 7135 - 7140.
[Abstract] [Full Text] [PDF]
S. Grossberg
How does the cerebral cortex work? development, learning, attention, and 3-D vision by laminar circuits of visual cortex.
Behav Cogn Neurosci Rev, March 1, 2003; 2(1): 47 - 76.
[Abstract] [PDF]
R. D. S. Raizada and S. Grossberg
Towards a Theory of the Laminar Architecture of Cerebral Cortex: Computational Clues from the Visual System
Cereb Cortex, January 1, 2003; 13(1): 100 - 113.
[Abstract] [Full Text] [PDF]
A. Kral, R. Hartmann, J. Tillein, S. Heid, and R. Klinke
Hearing after Congenital Deafness: Central Auditory Plasticity and Sensory Deprivation
Cereb Cortex, August 1, 2002; 12(8): 797 - 807.
[Abstract] [Full Text] [PDF]
H. Wallace, S. Glazewski, K. Liming, and K. Fox
The Role of Cortical Activity in Experience-Dependent Potentiation and Depression of Sensory Responses in Rat Barrel Cortex
J. Neurosci., June 1, 2001; 21(11): 3881 - 3894.
[Abstract] [Full Text] [PDF]
M. Tinazzi, A. Fiaschi, T. Rosso, F. Faccioli, J. Grosslercher, and S. M. Aglioti
Neuroplastic Changes Related to Pain Occur at Multiple Levels of the Human Somatosensory System: A Somatosensory-Evoked Potentials Study in Patients with Cervical Radicular Pain
J. Neurosci., December 15, 2000; 20(24): 9277 - 9283.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|