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The Journal of Neuroscience, October 1, 1999, 19(19):8712-8719
Time-Dependent Reversal of Long-Term Potentiation in Area CA1 of
the Freely Moving Rat Induced by Theta Pulse Stimulation
Ursula
Stäubli and
Joey
Scafidi
Center for Neural Science, New York University, New York, New York
10003
Previous studies in slices have shown that low-frequency
stimulation at 5 Hz, i.e., theta pulse stimulation (TPS), completely reverses long-term potentiation (LTP) in area CA1 when delivered within
1-2 min after induction but produces progressively less depotentiation
at longer delays, until it has no longer any impact at 30 min after
induction. The present study examined whether LTP in the freely moving
rat exhibits a similar time-dependent susceptibility to reversal. Adult
male Long-Evans rats with bilateral stimulating electrodes activating
collateral/commissural projections to area CA1 were used. A 1 min
episode of TPS, ineffective when applied to naive pathways, was found
to permanently erase LTP when delivered to the test pathway either 30 sec or 15 min after induction. Administered at a delay of 30 min,
however, the same treatment no longer had any impact on established
LTP. Additional experiments examined the ability of shorter TPS
episodes to erase LTP and found that a 30 sec treatment was effective
at 30 sec but not 15 min after induction. When the duration of TPS was
further reduced to 15 sec, a reversal was no longer obtained at any
delay. These results provide the first demonstration that the limited vulnerability of LTP to reversal by TPS, originally observed in vitro, also holds true for LTP in the awake animal and occurs along the same time frame, supporting the notion that LTP stabilization mechanisms take less than 30 min to be complete.
Key words:
depotentiation; in vivo; hippocampus; LTP
reversal; consolidation; chronic recording; retrograde amnesia; memory; TPS; depression; forgetting
Copyright © 1999 Society for Neuroscience 0270-6474/99/19198712-08$05.00/0
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