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The Journal of Neuroscience, 1999, 19:RC29:1-6

RAPID COMMUNICATION
Dopaminergic Correlates of Sensory-Specific Satiety in the Medial Prefrontal Cortex and Nucleus Accumbens of the Rat

Soyon Ahn and Anthony G. Phillips

Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4

Changes in dopamine (DA) efflux in the medial prefrontal cortex and nucleus accumbens of rats were monitored using in vivo microdialysis during sensory-specific satiety experiments. Rats consumed significant amounts of a palatable food during an initial meal but ate little when the same food was available as a second meal. In contrast, rats given a different palatable food ate a significant quantity during the second meal. DA efflux in both brain regions reflected this difference in food intake, indicating that DA activity is influenced by changes in the deprivation state of animals and sensory incentive properties of food. Given the proposed role of DA in motivated behaviors, these findings suggest that DA efflux may signal the relative incentive salience of foods and thus is a determinant of the pattern of food consumption observed in sensory-specific satiety.

Key words: sensory-specific satiety; dopamine; medial prefrontal cortex; nucleus accumbens; in vivo microdialysis; rat; appetitive and consummatory phases of feeding behavior; incentive motivation

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Copyright © 0000 Society for Neuroscience  0270-6474/0/$05.00/0

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