 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, January 15, 1999, 19(2):511-519
Presynaptic Effects of NMDA in Cerebellar Purkinje Cells and Interneurons
M. Glitsch and A. Marty Arbeitsgruppe Zelluläre Neurobiologie, Max-Planck-Institut für biophysikalische Chemie, 37077, Göttingen, Germany
NMDA receptors (NMDARs) are generally believed to mediate exclusively postsynaptic effects at brain synapses. Here we searched for presynaptic effects of NMDA at inhibitory synapses in rat cerebellar slices. In Purkinje cells, application of NMDA enhanced the frequency of miniature IPSCs (mIPSCs) but not that of miniature EPSCs (mEPSCs). This increase in frequency was dependent on the external Mg2+ concentration. In basket and stellate cells, NMDA induced an even larger mIPSC frequency increase than in Purkinje cells, whereas mEPSCs were again not affected. Moreover, NMDA induced an inward current in both types of interneuron, which translated into a small depolarization (~10 mV for 30 µM NMDA) under current-clamp conditions. In paired recordings of connected basket cell-Purkinje cell synapses, depolarizations of 10-30 mV applied to the basket cell soma enhanced the frequency of postsynaptic mIPSCs, suggesting that somatic depolarization was partially transmitted to the terminals in the presence of tetrodotoxin. However, this effect was small and unlikely to account fully for the effects of NMDA on mIPSCs. Consistent with a small number of dendritic NMDARs, evoked EPSCs in interneurons had a remarkably small NMDA component. Evoked IPSCs at interneuron-interneuron synapses were inhibited by NMDA, and the rate of failures was increased, indicating again a presynaptic site of action. We conclude that activation of NMDARs in interneurons exerts complex presynaptic effects, and that the corresponding receptors are most likely located in the axonal domain of the cell.
Key words: cerebellum; GABA; NMDA; presynaptic receptors; axon; stellate cell; basket cell
Copyright © 1999 Society for Neuroscience 0270-6474/99/192511-09$05.00/0
This article has been cited by other articles:
J. M. Christie and C. E. Jahr
Selective Expression of Ligand-Gated Ion Channels in L5 Pyramidal Cell Axons
J. Neurosci., September 16, 2009; 29(37): 11441 - 11450.
[Abstract] [Full Text] [PDF]
C. Bidoret, A. Ayon, B. Barbour, and M. Casado
Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule
PNAS, August 18, 2009; 106(33): 14126 - 14131.
[Abstract] [Full Text] [PDF]
Y. S. Kim, J. H. Shin, F. S. Hall, and D. J. Linden
Dopamine Signaling Is Required for Depolarization-Induced Slow Current in Cerebellar Purkinje Cells
J. Neurosci., July 1, 2009; 29(26): 8530 - 8538.
[Abstract] [Full Text] [PDF]
P. M. Lachamp, Y. Liu, and S. J. Liu
Glutamatergic Modulation of Cerebellar Interneuron Activity Is Mediated by an Enhancement of GABA Release and Requires Protein Kinase A/RIM1{alpha} Signaling
J. Neurosci., January 14, 2009; 29(2): 381 - 392.
[Abstract] [Full Text] [PDF]
R. Corlew, D. J. Brasier, D. E. Feldman, and B. D. Philpot
Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity
Neuroscientist, December 1, 2008; 14(6): 609 - 625.
[Abstract] [PDF]
B. Rossi, G. Maton, and T. Collin
Calcium-permeable presynaptic AMPA receptors in cerebellar molecular layer interneurones
J. Physiol., November 1, 2008; 586(21): 5129 - 5145.
[Abstract] [Full Text] [PDF]
L. W. J. Bosman, H. Takechi, J. Hartmann, J. Eilers, and A. Konnerth
Homosynaptic Long-Term Synaptic Potentiation of the "Winner" Climbing Fiber Synapse in Developing Purkinje Cells
J. Neurosci., January 23, 2008; 28(4): 798 - 807.
[Abstract] [Full Text] [PDF]
S. Astori and G. Kohr
Sustained granule cell activity disinhibits juvenile mouse cerebellar stellate cells through presynaptic mechanisms
J. Physiol., January 15, 2008; 586(2): 575 - 592.
[Abstract] [Full Text] [PDF]
F. F. Trigo, M. Chat, and A. Marty
Enhancement of GABA Release through Endogenous Activation of Axonal GABAA Receptors in Juvenile Cerebellum
J. Neurosci., November 14, 2007; 27(46): 12452 - 12463.
[Abstract] [Full Text] [PDF]
C. Piochon, T. Irinopoulou, D. Brusciano, Y. Bailly, J. Mariani, and C. Levenes
NMDA Receptor Contribution to the Climbing Fiber Response in the Adult Mouse Purkinje Cell
J. Neurosci., October 3, 2007; 27(40): 10797 - 10809.
[Abstract] [Full Text] [PDF]
L. Sun and S. June Liu
Activation of extrasynaptic NMDA receptors induces a PKC-dependent switch in AMPA receptor subtypes in mouse cerebellar stellate cells
J. Physiol., September 1, 2007; 583(2): 537 - 553.
[Abstract] [Full Text] [PDF]
Y.-H. Li and T.-Z. Han
Glycine Binding Sites of Presynaptic NMDA Receptors May Tonically Regulate Glutamate Release in the Rat Visual Cortex
J Neurophysiol, January 1, 2007; 97(1): 817 - 823.
[Abstract] [Full Text] [PDF]
S. J. Liu and P. Lachamp
The Activation of Excitatory Glutamate Receptors Evokes a Long-Lasting Increase in the Release of GABA from Cerebellar Stellate Cells
J. Neurosci., September 6, 2006; 26(36): 9332 - 9339.
[Abstract] [Full Text] [PDF]
M. Glitsch
Selective Inhibition of Spontaneous But Not Ca2+-Dependent Release Machinery by Presynaptic Group II mGluRs in Rat Cerebellar Slices
J Neurophysiol, July 1, 2006; 96(1): 86 - 96.
[Abstract] [Full Text] [PDF]
V. A. Bender, K. J. Bender, D. J. Brasier, and D. E. Feldman
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
J. Neurosci., April 19, 2006; 26(16): 4166 - 4177.
[Abstract] [Full Text] [PDF]
M. Hirono and K. Obata
{alpha}-Adrenoceptive Dual Modulation of Inhibitory GABAergic Inputs to Purkinje Cells in the Mouse Cerebellum
J Neurophysiol, February 1, 2006; 95(2): 700 - 708.
[Abstract] [Full Text] [PDF]
J. Yang, G. L. Woodhall, and R. S. G. Jones
Tonic Facilitation of Glutamate Release by Presynaptic NR2B-Containing NMDA Receptors Is Increased in the Entorhinal Cortex of Chronically Epileptic Rats
J. Neurosci., January 11, 2006; 26(2): 406 - 410.
[Abstract] [Full Text] [PDF]
J. H. Shin and D. J. Linden
An NMDA Receptor/Nitric Oxide Cascade Is Involved in Cerebellar LTD But Is Not Localized to the Parallel Fiber Terminal
J Neurophysiol, December 1, 2005; 94(6): 4281 - 4289.
[Abstract] [Full Text] [PDF]
M. E. Calcagnotto and S. C. Baraban
Prolonged NMDA-Mediated Responses, Altered Ifenprodil Sensitivity, and Epileptiform-Like Events in the Malformed Hippocampus of Methylazoxymethanol Exposed Rats
J Neurophysiol, July 1, 2005; 94(1): 153 - 162.
[Abstract] [Full Text] [PDF]
P. Lachamp, B. Balland, F. Tell, A. Baude, C. Strube, M. Crest, and J.-P. Kessler
Early expression of AMPA receptors and lack of NMDA receptors in developing rat climbing fibre synapses
J. Physiol., May 1, 2005; 564(3): 751 - 763.
[Abstract] [Full Text] [PDF]
M. L. Fiszman, A. Barberis, C. Lu, Z. Fu, F. Erdelyi, G. Szabo, and S. Vicini
NMDA Receptors Increase the Size of GABAergic Terminals and Enhance GABA Release
J. Neurosci., February 23, 2005; 25(8): 2024 - 2031.
[Abstract] [Full Text] [PDF]
R. D. Samson and D. Pare
Activity-Dependent Synaptic Plasticity in the Central Nucleus of the Amygdala
J. Neurosci., February 16, 2005; 25(7): 1847 - 1855.
[Abstract] [Full Text] [PDF]
C.-Y. Chen and A. C. Bonham
Glutamate suppresses GABA release via presynaptic metabotropic glutamate receptors at baroreceptor neurones in rats
J. Physiol., January 15, 2005; 562(2): 535 - 551.
[Abstract] [Full Text] [PDF]
H. Huang, L. Barakat, D. Wang, and A. Bordey
Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices
J. Physiol., November 1, 2004; 560(3): 721 - 736.
[Abstract] [Full Text] [PDF]
S. G. Cull-Candy and D. N. Leszkiewicz
Role of Distinct NMDA Receptor Subtypes at Central Synapses
Sci. Signal., October 19, 2004; 2004(255): re16 - re16.
[Abstract] [Full Text] [PDF]
M. H. Karakossian and T. S. Otis
Excitation of Cerebellar Interneurons by Group I Metabotropic Glutamate Receptors
J Neurophysiol, September 1, 2004; 92(3): 1558 - 1565.
[Abstract] [Full Text] [PDF]
H. Huang and A. Bordey
Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons
J. Neurosci., June 23, 2004; 24(25): 5659 - 5669.
[Abstract] [Full Text] [PDF]
R. Bardoni, C. Torsney, C.-K. Tong, M. Prandini, and A. B. MacDermott
Presynaptic NMDA Receptors Modulate Glutamate Release from Primary Sensory Neurons in Rat Spinal Cord Dorsal Horn
J. Neurosci., March 17, 2004; 24(11): 2774 - 2781.
[Abstract] [Full Text] [PDF]
M. Galante and A. Marty
Presynaptic Ryanodine-Sensitive Calcium Stores Contribute to Evoked Neurotransmitter Release at the Basket Cell-Purkinje Cell Synapse
J. Neurosci., December 3, 2003; 23(35): 11229 - 11234.
[Abstract] [Full Text] [PDF]
J. Brockhaus and J. W Deitmer
Long-lasting modulation of synaptic input to Purkinje neurons by Bergmann glia stimulation in rat brain slices
J. Physiol., December 1, 2002; 545(2): 581 - 593.
[Abstract] [Full Text] [PDF]
C.-R. Lu, S. J. Hwang, K. D. Phend, A. Rustioni, and J. G. Valtschanoff
Primary Afferent Terminals in Spinal Cord Express Presynaptic AMPA Receptors
J. Neurosci., November 1, 2002; 22(21): 9522 - 9529.
[Abstract] [Full Text] [PDF]
F. Georges and G. Aston-Jones
Activation of Ventral Tegmental Area Cells by the Bed Nucleus of the Stria Terminalis: A Novel Excitatory Amino Acid Input to Midbrain Dopamine Neurons
J. Neurosci., June 15, 2002; 22(12): 5173 - 5187.
[Abstract] [Full Text] [PDF]
B. A. Clark and S. G. Cull-Candy
Activity-Dependent Recruitment of Extrasynaptic NMDA Receptor Activation at an AMPA Receptor-Only Synapse
J. Neurosci., June 1, 2002; 22(11): 4428 - 4436.
[Abstract] [Full Text] [PDF]
K. Kawa
Acute synaptic modulation by nicotinic agonists in developing cerebellar Purkinje cells of the rat
J. Physiol., January 1, 2002; 538(1): 87 - 102.
[Abstract] [Full Text] [PDF]
G. Woodhall, D. I. Evans, M. O. Cunningham, and R. S. G. Jones
NR2B-Containing NMDA Autoreceptors at Synapses on Entorhinal Cortical Neurons
J Neurophysiol, October 1, 2001; 86(4): 1644 - 1651.
[Abstract] [Full Text] [PDF]
W.-H. Yung, P.-S. Leung, S. S. M. Ng, J. Zhang, S. C. Y. Chan, and B. K. C. Chow
Secretin Facilitates GABA Transmission in the Cerebellum
J. Neurosci., September 15, 2001; 21(18): 7063 - 7068.
[Abstract] [Full Text] [PDF]
M. Takahashi, R. Freed, T. Blackmer, and S. Alford
Calcium influx-independent depression of transmitter release by 5-HT at lamprey spinal cord synapses
J. Physiol., April 15, 2001; 532(2): 323 - 336.
[Abstract] [Full Text] [PDF]
A. Contractor, G. T. Swanson, A. Sailer, S. O'Gorman, and S. F. Heinemann
Identification of the Kainate Receptor Subunits Underlying Modulation of Excitatory Synaptic Transmission in the CA3 Region of the Hippocampus
J. Neurosci., November 15, 2000; 20(22): 8269 - 8278.
[Abstract] [Full Text] [PDF]
F. Saitow, S.'I. Satake, J. Yamada, and S. Konishi
beta -Adrenergic Receptor-Mediated Presynaptic Facilitation of Inhibitory GABAergic Transmission at Cerebellar Interneuron-Purkinje Cell Synapses
J Neurophysiol, October 1, 2000; 84(4): 2016 - 2025.
[Abstract] [Full Text] [PDF]
M. Casado, S. Dieudonné, and P. Ascher
Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse
PNAS, September 29, 2000; (2000) 200354297.
[Abstract] [Full Text]
N. E. Schwartz and S. Alford
Physiological Activation of Presynaptic Metabotropic Glutamate Receptors Increases Intracellular Calcium and Glutamate Release
J Neurophysiol, July 1, 2000; 84(1): 415 - 427.
[Abstract] [Full Text] [PDF]
A. G. Carter and W. G. Regehr
Prolonged Synaptic Currents and Glutamate Spillover at the Parallel Fiber to Stellate Cell Synapse
J. Neurosci., June 15, 2000; 20(12): 4423 - 4434.
[Abstract] [Full Text] [PDF]
M. Casado, S. Dieudonne, and P. Ascher
Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse
PNAS, October 10, 2000; 97(21): 11593 - 11597.
[Abstract] [Full Text] [PDF]
K. Kawa
Acute synaptic modulation by nicotinic agonists in developing cerebellar Purkinje cells of the rat
J. Physiol., January 1, 2002; 538(1): 87 - 102.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|