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The Journal of Neuroscience, January 15, 1999, 19(2):653-663
Kainate Receptor-Mediated Responses in the CA1 Field of Wild-Type
and GluR6-Deficient Mice
Ingrid
Bureau1,
Serge
Bischoff2,
Steve F.
Heinemann3, and
Christophe
Mulle1
1 Centre National de la Recherche Scientifique,
Université Victor Segalen, Bordeaux 33076, France,
2 Novartis, CH-4002, Basel, Switzerland, and
3 Molecular Neurobiology Laboratory, The Salk Institute for
Biological Studies, La Jolla, California 92037
Kainate receptors are abundantly expressed in the hippocampus. Mice
with disruption of kainate receptor subunits allow the genetic
dissection of the role of each kainate receptor subunits in the
synaptic physiology of the hippocampus, as well as in excitotoxic processes. We have compared the action of domoate and kainate on CA1
pyramidal neurons in slices from wild-type and GluR6 / mice. The
difference in the amplitude of inward currents evoked by domoate and
kainate between wild-type and GluR6/ mice demonstrates the presence
of functional kainate receptors in CA1 pyramidal neurons. Block of
domoate-activated inward currents by the AMPA receptor
antagonists
2,3-dihydroxy-6-nitro-7-sulfonyl-benzo(F)quinoxaline (1 µM) and
1-(4-aminophenyl)-3-methylcarbamyl-4-methyl7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine) (GYKI 53655) (50 µM) is complete in
GluR6/ mice but only partial in wild-type mice. In the presence of
GYKI 53655, kainate receptor activation dramatically increases the
frequency of spontaneous IPSCs in CA1 pyramidal cells from wild-type,
as well as GluR6/, mice. This results from the kainate
receptor-mediated activation of a sustained inward current and an
increased action potential firing in afferent GABAergic interneurons of
the CA1 field. These effects are observed in wild-type, as well as
GluR6/, mice. Kainate receptors also decrease the amplitude of
evoked IPSCs in CA1 pyramidal cells by increasing synaptic failures in
wild-type and GluR6/ mice. These results indicate that in CA1
pyramidal cells, distinct subtypes of kainate receptors mediate several functionally antagonistic effects.
Key words:
kainate receptors; GluR6 knock-out mouse; CA1 pyramidal
cells; CA1 interneurons; NBQX; GYKI 53655
Copyright © 1999 Society for Neuroscience 0270-6474/99/192653-11$05.00/0
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