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Previous Article | Next Article
The Journal of Neuroscience, January 15, 1999, 19(2):747-758
Dynamic Potassium Channel Distributions during Axonal Development Prevent Aberrant Firing Patterns
Ian Vabnick1, James S. Trimmer3, Thomas L. Schwarz4, S. Rock Levinson5, Dipesh Risal1, and Peter Shrager1, 2 Departments of 1 Biochemistry and Biophysics and 2 Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York 14642, 3 Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794, 4 Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, Stanford, California 94305, and 5 Department of Physiology, University of Colorado, Denver, Colorado 80262
The distribution and function of Shaker-related K+ channels were studied with immunofluorescence and electrophysiology in sciatic nerves of developing rats. At nodes of Ranvier, Na+ channel clustering occurred very early (postnatal days 1-3). Although K+ channels were not yet segregated at most of these sites, they were directly involved in action potential generation, reducing duration, and the refractory period. At ~1 week, K+ channel clusters were first seen but were within the nodal gap and in paranodes, and only later (weeks 2-4) were they shifted to juxtaparanodal regions. K+ channel function was most dramatic during this transition period, with block producing repetitive firing in response to single stimuli. As K+ channels were increasingly sequestered in juxtaparanodes, conduction became progressively insensitive to K+ channel block. Over the first 3 weeks, K+ channel clustering was often asymmetric, with channels exclusively in the distal paranode in ~40% of cases. A computational model suggested a mechanism for the firing patterns observed, and the results provide a role for K+ channels in the prevention of aberrant excitation as myelination proceeds during development.
Key words: potassium channels; node of Ranvier; Schwann cell; myelin; axons; development
Copyright © 1999 Society for Neuroscience 0270-6474/99/192747-12$05.00/0
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