 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, January 15, 1999, 19(2):794-801
Polysialic Acid Facilitates Migration of Luteinizing Hormone-Releasing Hormone Neurons on Vomeronasal Axons
Keiko Yoshida1, Urs Rutishauser3, James E. Crandall1, and Gerald A. Schwarting1, 2 1 The Shriver Center, Waltham, Massachusetts 02452, 2 The Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, and 3 Program in Cellular Biochemistry and Biophysics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021
Luteinizing hormone-releasing hormone (LHRH) neurons migrate from the olfactory placode to the forebrain in association with vomeronasal nerves (VNN) that express the polysialic acid-rich form of the neural cell adhesion molecule (PSA-NCAM). Two approaches were used to investigate the role of PSA-NCAM: injection of mouse embryos with endoneuraminidase N, followed by the analysis of LHRH cell positions, and examination of LHRH cell positions in mutant mice deficient in the expression of NCAM or the NCAM-180 isoform, which carries nearly all PSA in the brain. The enzymatic removal of PSA at embryonic day 12 significantly inhibited the migration of nearly half of the LHRH neuron population, without affecting the VNN tract itself. Surprisingly, the absence of NCAM or NCAM-180 did not produce this effect. However, a shift in the route of migration, resulting in an excess number of LHRH cells in the accessory olfactory bulb, was observed in the NCAM-180 mutant. Furthermore, it was found that PSA expressed by the proximal VNN and its distal branch leading to the accessory bulb, but not the branch leading to the forebrain, was associated with the NCAM-140 isoform and thus was retained in the NCAM-180 mutant. These results provide two types of evidence that PSA-NCAM plays a role in LHRH cell migration: promotion of cell movement along the VNN tract that is sensitive to acute (enzymatic), but not chronic (genetic), removal of PSA-NCAM, and a preference of a subset of migrating LHRH cells for a PSA-positive axon branch over a PSA-negative branch in the NCAM-180 mutant.
Key words: polysialic acid; neuronal migration; LHRH neurons; olfactory system; NCAM; vomeronasal organ
Copyright © 1999 Society for Neuroscience 0270-6474/99/192794-08$05.00/0
This article has been cited by other articles:
P. Giacobini, A. Messina, S. Wray, C. Giampietro, T. Crepaldi, P. Carmeliet, and A. Fasolo
Hepatocyte Growth Factor Acts as a Motogen and Guidance Signal for Gonadotropin Hormone-Releasing Hormone-1 Neuronal Migration
J. Neurosci., January 10, 2007; 27(2): 431 - 445.
[Abstract] [Full Text] [PDF]
A. El Maarouf, A. K. Petridis, and U. Rutishauser
Use of polysialic acid in repair of the central nervous system
PNAS, November 7, 2006; 103(45): 16989 - 16994.
[Abstract] [Full Text] [PDF]
G. A. Schwarting, T. R. Henion, J. D. Nugent, B. Caplan, and S. Tobet
Stromal cell-derived factor-1 (chemokine C-X-C motif ligand 12) and chemokine C-X-C motif receptor 4 are required for migration of gonadotropin-releasing hormone neurons to the forebrain.
J. Neurosci., June 21, 2006; 26(25): 6834 - 6840.
[Abstract] [Full Text] [PDF]
S. A. Tobet and G. A. Schwarting
Minireview: Recent Progress in Gonadotropin-Releasing Hormone Neuronal Migration
Endocrinology, March 1, 2006; 147(3): 1159 - 1165.
[Abstract] [Full Text] [PDF]
A. El Maarouf, Y. Kolesnikov, G. Pasternak, and U. Rutishauser
Polysialic acid-induced plasticity reduces neuropathic insult to the central nervous system
PNAS, August 9, 2005; 102(32): 11516 - 11520.
[Abstract] [Full Text] [PDF]
J. Parkash and G. Kaur
Neuronal-glial plasticity in gonadotropin-releasing hormone release in adult female rats: role of the polysialylated form of the neural cell adhesion molecule
J. Endocrinol., August 1, 2005; 186(2): 397 - 409.
[Abstract] [Full Text] [PDF]
C. Giampietro, F. Luzzati, G. Gambarotta, P. Giacobini, E. Boda, A. Fasolo, and I. Perroteau
Stathmin Expression Modulates Migratory Properties of GN-11 Neurons in Vitro
Endocrinology, April 1, 2005; 146(4): 1825 - 1834.
[Abstract] [Full Text] [PDF]
J. A. Gamble, D. K. Karunadasa, J.-R. Pape, M. J. Skynner, M. G. Todman, R. J. Bicknell, J. P. Allen, and A. E. Herbison
Disruption of Ephrin Signaling Associates with Disordered Axophilic Migration of the Gonadotropin-Releasing Hormone Neurons
J. Neurosci., March 23, 2005; 25(12): 3142 - 3150.
[Abstract] [Full Text] [PDF]
A. Cariboni, F. Pimpinelli, S. Colamarino, R. Zaninetti, M. Piccolella, C. Rumio, F. Piva, E. I. Rugarli, and R. Maggi
The product of X-linked Kallmann's syndrome gene (KAL1) affects the migratory activity of gonadotropin-releasing hormone (GnRH)-producing neurons
Hum. Mol. Genet., November 15, 2004; 13(22): 2781 - 2791.
[Abstract] [Full Text] [PDF]
L. Nguyen, B. Malgrange, I. Breuskin, L. Bettendorff, G. Moonen, S. Belachew, and J.-M. Rigo
Autocrine/Paracrine Activation of the GABAA Receptor Inhibits the Proliferation of Neurogenic Polysialylated Neural Cell Adhesion Molecule-Positive (PSA-NCAM+) Precursor Cells from Postnatal Striatum
J. Neurosci., April 15, 2003; 23(8): 3278 - 3294.
[Abstract] [Full Text] [PDF]
A. Corradi, L. Croci, V. Broccoli, S. Zecchini, S. Previtali, W. Wurst, S. Amadio, R. Maggi, A. Quattrini, and G. G. Consalez
Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice
Development, March 2, 2003; 130(2): 401 - 410.
[Abstract] [Full Text] [PDF]
P. Giacobini, C. Giampietro, M. Fioretto, R. Maggi, A. Cariboni, I. Perroteau, and A. Fasolo
Hepatocyte Growth Factor/Scatter Factor Facilitates Migration of GN-11 Immortalized LHRH Neurons
Endocrinology, September 1, 2002; 143(9): 3306 - 3315.
[Abstract] [Full Text] [PDF]
C. Viguie, H. T. Jansen, J. D. Glass, M. Watanabe, H. J. Billings, L. Coolen, M. N. Lehman, and F. J. Karsch
Potential for Polysialylated Form of Neural Cell Adhesion Molecule-Mediated Neuroplasticity within the Gonadotropin-Releasing Hormone Neurosecretory System of the Ewe
Endocrinology, March 1, 2001; 142(3): 1317 - 1324.
[Abstract] [Full Text] [PDF]
G. A. Schwarting, C. Kostek, E. P. Bless, N. Ahmad, and S. A. Tobet
Deleted in Colorectal Cancer (DCC) Regulates the Migration of Luteinizing Hormone-Releasing Hormone Neurons to the Basal Forebrain
J. Neurosci., February 1, 2001; 21(3): 911 - 919.
[Abstract] [Full Text] [PDF]
S. X. Simonian and A. E. Herbison
Differing, Spatially Restricted Roles of Ionotropic Glutamate Receptors in Regulating the Migration of GnRH Neurons during Embryogenesis
J. Neurosci., February 1, 2001; 21(3): 934 - 943.
[Abstract] [Full Text] [PDF]
F. Muscatelli, D. N. Abrous, A. Massacrier, I. Boccaccio, M. L. Moal, P. Cau, and H. Cremer
Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome
Hum. Mol. Genet., December 1, 2000; 9(20): 3101 - 3110.
[Abstract] [Full Text] [PDF]
P.R. Kramer and S. Wray
Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons
Genes & Dev., July 15, 2000; 14(14): 1824 - 1834.
[Abstract] [Full Text]
E. P. Bless, W. A. Westaway, G. A. Schwarting, and S. A. Tobet
Effects of {gamma}-Aminobutyric AcidA Receptor Manipulation on Migrating Gonadotropin-Releasing Hormone Neurons through the Entire Migratory Route in Vivo and in Vitro
Endocrinology, March 1, 2000; 141(3): 1254 - 1262.
[Abstract] [Full Text] [PDF]
D. T. Theodosis, R. Bonhomme, S. Vitiello, G. Rougon, and D. A. Poulain
Cell Surface Expression of Polysialic Acid on NCAM Is a Prerequisite for Activity-Dependent Morphological Neuronal and Glial Plasticity
J. Neurosci., December 1, 1999; 19(23): 10228 - 10236.
[Abstract] [Full Text] [PDF]
S. Anderson, M. Mione, K. Yun, and J. L.R. Rubenstein
Differential Origins of Neocortical Projection and Local Circuit Neurons: Role of Dlx Genes in Neocortical Interneuronogenesis
Cereb Cortex, September 1, 1999; 9(6): 646 - 654.
[Abstract] [Full Text] [PDF]
S. Kitazume-Kawaguchi, S. Kabata, and M. Arita
Differential Biosynthesis of Polysialic or Disialic Acid Structure by ST8Sia II and ST8Sia IV
J. Biol. Chem., May 4, 2001; 276(19): 15696 - 15703.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|