 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, January 15, 1999, 19(2):836-844
Reciprocal Changes in the Firing Probability of Lateral and Central Medial Amygdala Neurons
Dawn R. Collins and Denis Paré Laboratoire de Neurophysiologie, Département de Physiologie, Faculté de Médecine, Université Laval, Québec, Canada G1K 7P4
The amygdala is essential for classical fear conditioning. According to the current model of auditory fear conditioning, the lateral nucleus is the input station of the amygdala for conditioned auditory stimuli, whereas the central nucleus is the output station for conditioned fear responses. Yet, the lateral nucleus does not project to the central medial nucleus, where most brainstem projections of the amygdala originate. The available evidence suggests that the basal nuclei could transmit information from the lateral to the central medial nucleus. However, interposed between the basolateral complex and the central nucleus are clusters of GABAergic cells, the intercalated neurons, which receive inputs from the lateral and basal nuclei and contribute a massive projection to the central medial nucleus. Because it is impossible to predict the consequences of these connections, we correlated the spontaneous and auditory-evoked activity of multiple simultaneously recorded neurons of the lateral, basal, and central nuclei. The spontaneous activity of lateral and basolateral neurons was positively correlated to that of central lateral cells but negatively correlated to that of central medial neurons. In response to auditory stimuli, the firing probability of lateral and central medial neurons oscillated in phase opposition, initially being excited and inhibited, respectively. In light of previous anatomical findings, we propose that the lateral nucleus exerts two indirect actions on central medial neurons: an excitation via the basal nuclei and an inhibition via intercalated neurons.
Key words: amygdala; fear conditioning; multisite recording; lateral amygdala; intra-amygdaloid pathways; intercalated cell masses
Copyright © 1999 Society for Neuroscience 0270-6474/99/192836-09$05.00/0
This article has been cited by other articles:
T. Kudo, T. Fujii, S. Ikegami, K. Inokuchi, Y. Takayama, Y. Ikehara, S. Nishihara, A. Togayachi, S. Takahashi, K. Tachibana, et al.
Mice lacking {alpha}1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors
Glycobiology, January 1, 2007; 17(1): 1 - 9.
[Abstract] [Full Text] [PDF]
P. J. Zhu, R. R. Stewart, J. M. McIntosh, and F. F. Weight
Activation of Nicotinic Acetylcholine Receptors Increases the Frequency of Spontaneous GABAergic IPSCs in Rat Basolateral Amygdala Neurons
J Neurophysiol, November 1, 2005; 94(5): 3081 - 3091.
[Abstract] [Full Text] [PDF]
J. G. Pelletier, E. Likhtik, M. Filali, and D. Pare
Lasting increases in basolateral amygdala activity after emotional arousal: Implications for facilitated consolidation of emotional memories
Learn. Mem., March 1, 2005; 12(2): 96 - 102.
[Abstract] [Full Text] [PDF]
F. Sotres-Bayon, D. E.A. Bush, and J. E. LeDoux
Emotional Perseveration: An Update on Prefrontal-Amygdala Interactions in Fear Extinction
Learn. Mem., September 1, 2004; 11(5): 525 - 535.
[Abstract] [Full Text] [PDF]
J. G. Pelletier, J. Apergis, and D. Pare
Low-Probability Transmission of Neocortical and Entorhinal Impulses Through the Perirhinal Cortex
J Neurophysiol, May 1, 2004; 91(5): 2079 - 2089.
[Abstract] [Full Text] [PDF]
J. L. Fudge and A. B. Emiliano
The Extended Amygdala and the Dopamine System: Another Piece of the Dopamine Puzzle
J Neuropsychiatry Clin Neurosci, August 1, 2003; 15(3): 306 - 316.
[Abstract] [Full Text]
D. PARE, S. ROYER, Y. SMITH, and E. J. LANG
Contextual Inhibitory Gating of Impulse Traffic in the Intra-amygdaloid Network
Ann. N.Y. Acad. Sci., April 1, 2003; 985(1): 78 - 91.
[Abstract] [Full Text] [PDF]
H.-C. PAPE and O. STORK
Genes and Mechanisms in the Amygdala Involved in the Formation of Fear Memory
Ann. N.Y. Acad. Sci., April 1, 2003; 985(1): 92 - 105.
[Abstract] [Full Text] [PDF]
J. G. Pelletier and D. Pare
Uniform Range of Conduction Times From the Lateral Amygdala to Distributed Perirhinal Sites
J Neurophysiol, March 1, 2002; 87(3): 1213 - 1221.
[Abstract] [Full Text] [PDF]
I. Katona, E. A. Rancz, L. Acsady, C. Ledent, K. Mackie, N. Hajos, and T. F. Freund
Distribution of CB1 Cannabinoid Receptors in the Amygdala and their Role in the Control of GABAergic Transmission
J. Neurosci., December 1, 2001; 21(23): 9506 - 9518.
[Abstract] [Full Text] [PDF]
D. R. Collins, J. G. Pelletier, and D. Pare
Slow and Fast (Gamma) Neuronal Oscillations in the Perirhinal Cortex and Lateral Amygdala
J Neurophysiol, April 1, 2001; 85(4): 1661 - 1672.
[Abstract] [Full Text] [PDF]
J. M. Beggs
A Statistical Theory of Long-Term Potentiation and Depression
Neural Comput., January 1, 2001; 13(1): 87 - 111.
[Abstract] [Full Text]
D. Pare and D. R. Collins
Neuronal Correlates of Fear in the Lateral Amygdala: Multiple Extracellular Recordings in Conscious Cats
J. Neurosci., April 1, 2000; 20(7): 2701 - 2710.
[Abstract] [Full Text] [PDF]
D. R. Collins and D. Paré
Differential Fear Conditioning Induces Reciprocal Changes in the Sensory Responses of Lateral Amygdala Neurons to the CS+ and CS-
Learn. Mem., March 1, 2000; 7(2): 97 - 103.
[Abstract] [Full Text]
S. Royer, M. Martina, and D. Pare
An Inhibitory Interface Gates Impulse Traffic between the Input and Output Stations of the Amygdala
J. Neurosci., December 1, 1999; 19(23): 10575 - 10583.
[Abstract] [Full Text] [PDF]
M. Martina, S. Royer, and D. Pare
Physiological Properties of Central Medial and Central Lateral Amygdala Neurons
J Neurophysiol, October 1, 1999; 82(4): 1843 - 1854.
[Abstract] [Full Text] [PDF]
T. Heinbockel and H.-C. Pape
Input-Specific Long-Term Depression in the Lateral Amygdala Evoked by Theta Frequency Stimulation
J. Neurosci., April 1, 2000; 20(7): RC68 - RC68.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|