 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, November 1, 1999, 19(21):9557-9569
The Fundamental Role of Pirouettes in Caenorhabditis elegans Chemotaxis
Jonathan T. Pierce-Shimomura, Thomas M. Morse, and Shawn R. Lockery Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403-1254
To investigate the behavioral mechanism of chemotaxis in Caenorhabditis elegans, we recorded the instantaneous position, speed, and turning rate of single worms as a function of time during chemotaxis in gradients of the attractants ammonium chloride or biotin. Analysis of turning rate showed that each worm track could be divided into periods of smooth swimming (runs) and periods of frequent turning (pirouettes). The initiation of pirouettes was correlated with the rate of change of concentration (dC/dt) but not with absolute concentration. Pirouettes were most likely to occur when a worm was heading down the gradient (dC/dt < 0) and least likely to occur when a worm was heading up the gradient (dC/dt > 0). Further analysis revealed that the average direction of movement after a pirouette was up the gradient. These observations suggest that chemotaxis is produced by a series of pirouettes that reorient the animal to the gradient. We tested this idea by imposing the correlation between pirouettes and dC/dt on a stochastic point model of worm motion. The model exhibited chemotaxis behavior in a radial gradient and also in a novel planar gradient. Thus, the pirouette model of C. elegans chemotaxis is sufficient and general.
Key words: nematode; chemosensation; spatial orientation; neural computation; behavioral models; sensorimotor integration
Copyright © 1999 Society for Neuroscience 0270-6474/99/19219557-13$05.00/0
This article has been cited by other articles:
Y. Iino and K. Yoshida
Parallel Use of Two Behavioral Mechanisms for Chemotaxis in Caenorhabditis elegans
J. Neurosci., April 29, 2009; 29(17): 5370 - 5380.
[Abstract] [Full Text] [PDF]
G. P. Harris, V. M. Hapiak, R. T. Wragg, S. B. Miller, L. J. Hughes, R. J. Hobson, R. Steven, B. Bamber, and R. W. Komuniecki
Three Distinct Amine Receptors Operating at Different Levels within the Locomotory Circuit Are Each Essential for the Serotonergic Modulation of Chemosensation in Caenorhabditis elegans
J. Neurosci., February 4, 2009; 29(5): 1446 - 1456.
[Abstract] [Full Text] [PDF]
D. Ramot, B. L. MacInnis, H.-C. Lee, and M. B. Goodman
Thermotaxis is a Robust Mechanism for Thermoregulation in Caenorhabditis elegans Nematodes
J. Neurosci., November 19, 2008; 28(47): 12546 - 12557.
[Abstract] [Full Text] [PDF]
D. Biron, S. Wasserman, J. H. Thomas, A. D. T. Samuel, and P. Sengupta
An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behavior
PNAS, August 5, 2008; 105(31): 11002 - 11007.
[Abstract] [Full Text] [PDF]
J. S. Dittman and J. M. Kaplan
Behavioral Impact of Neurotransmitter-Activated G-Protein-Coupled Receptors: Muscarinic and GABAB Receptors Regulate Caenorhabditis elegans Locomotion
J. Neurosci., July 9, 2008; 28(28): 7104 - 7112.
[Abstract] [Full Text] [PDF]
S. R. Lockery, K. J. Lawton, J. C. Doll, S. Faumont, S. M. Coulthard, T. R. Thiele, N. Chronis, K. E. McCormick, M. B. Goodman, and B. L. Pruitt
Artificial Dirt: Microfluidic Substrates for Nematode Neurobiology and Behavior
J Neurophysiol, June 1, 2008; 99(6): 3136 - 3143.
[Abstract] [Full Text] [PDF]
L. Luo, C. V. Gabel, H.-I. Ha, Y. Zhang, and A. D. T. Samuel
Olfactory Behavior of Swimming C. elegans Analyzed by Measuring Motile Responses to Temporal Variations of Odorants
J Neurophysiol, May 1, 2008; 99(5): 2617 - 2625.
[Abstract] [Full Text] [PDF]
N. A. Dunn, J. S. Conery, and S. R. Lockery
Circuit Motifs for Spatial Orientation Behaviors Identified by Neural Network Optimization
J Neurophysiol, August 1, 2007; 98(2): 888 - 897.
[Abstract] [Full Text] [PDF]
C. V. Gabel, H. Gabel, D. Pavlichin, A. Kao, D. A. Clark, and A. D. T. Samuel
Neural Circuits Mediate Electrosensory Behavior in Caenorhabditis elegans
J. Neurosci., July 11, 2007; 27(28): 7586 - 7596.
[Abstract] [Full Text] [PDF]
D. A. Clark, C. V. Gabel, T. M. Lee, and A. D. T. Samuel
Short-Term Adaptation and Temporal Processing in the Cryophilic Response of Caenorhabditis elegans
J Neurophysiol, March 1, 2007; 97(3): 1903 - 1910.
[Abstract] [Full Text] [PDF]
L. Luo, D. A. Clark, D. Biron, L. Mahadevan, and A. D. T. Samuel
Sensorimotor control during isothermal tracking in Caenorhabditis elegans
J. Exp. Biol., December 1, 2006; 209(23): 4652 - 4662.
[Abstract] [Full Text] [PDF]
B. B. Shtonda and L. Avery
Dietary choice behavior in Caenorhabditis elegans
J. Exp. Biol., January 1, 2006; 209(1): 89 - 102.
[Abstract] [Full Text] [PDF]
J. T. Pierce-Shimomura, M. Dores, and S. R. Lockery
Analysis of the effects of turning bias on chemotaxis in C. elegans
J. Exp. Biol., December 15, 2005; 208(24): 4727 - 4733.
[Abstract] [Full Text] [PDF]
B. C. Ajie, S. Estes, M. Lynch, and P. C. Phillips
Behavioral Degradation Under Mutation Accumulation in Caenorhabditis elegans
Genetics, June 1, 2005; 170(2): 655 - 660.
[Abstract] [Full Text] [PDF]
A. C. Miller, T. R. Thiele, S. Faumont, M. L. Moravec, and S. R. Lockery
Step-Response Analysis of Chemotaxis in Caenorhabditis elegans
J. Neurosci., March 30, 2005; 25(13): 3369 - 3378.
[Abstract] [Full Text] [PDF]
J. M. Gray, J. J. Hill, and C. I. Bargmann
Inaugural Article: A circuit for navigation in Caenorhabditis elegans
PNAS, March 1, 2005; 102(9): 3184 - 3191.
[Abstract] [Full Text] [PDF]
C. F. Glenn, D. K. Chow, L. David, C. A. Cooke, M. S. Gami, W. B. Iser, K. B. Hanselman, I. G. Goldberg, and C. A. Wolkow
Behavioral Deficits During Early Stages of Aging in Caenorhabditis elegans Result From Locomotory Deficits Possibly Linked to Muscle Frailty
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2004; 59(12): 1251 - 1260.
[Abstract] [Full Text] [PDF]
J. Lipton, G. Kleemann, R. Ghosh, R. Lints, and S. W. Emmons
Mate Searching in Caenorhabditis elegans: A Genetic Model for Sex Drive in a Simple Invertebrate
J. Neurosci., August 25, 2004; 24(34): 7427 - 7434.
[Abstract] [Full Text] [PDF]
T. Hills, P. J. Brockie, and A. V. Maricq
Dopamine and Glutamate Control Area-Restricted Search Behavior in Caenorhabditis elegans
J. Neurosci., February 4, 2004; 24(5): 1217 - 1225.
[Abstract] [Full Text] [PDF]
V. A. Nepomnyashchikh and K. A. Podgornyj
Emergence of Adaptive Searching Rules from the Dynamics of a Simple Nonlinear System
Adaptive Behavior, December 1, 2003; 11(4): 245 - 265.
[Abstract] [PDF]
B. Zhao, P. Khare, L. Feldman, and J. A. Dent
Reversal Frequency in Caenorhabditis elegans Represents an Integrated Response to the State of the Animal and Its Environment
J. Neurosci., June 15, 2003; 23(12): 5319 - 5328.
[Abstract] [Full Text] [PDF]
H. A. Zariwala, A. C. Miller, S. Faumont, and S. R. Lockery
Step Response Analysis of Thermotaxis in Caenorhabditis elegans
J. Neurosci., May 15, 2003; 23(10): 4369 - 4377.
[Abstract] [Full Text] [PDF]
F. W. Wolf, A. R. Rodan, L. T.-Y. Tsai, and U. Heberlein
High-Resolution Analysis of Ethanol-Induced Locomotor Stimulation in Drosophila
J. Neurosci., December 15, 2002; 22(24): 11035 - 11044.
[Abstract] [Full Text] [PDF]
W. S. Ryu and A. D. T. Samuel
Thermotaxis in Caenorhabditis elegans Analyzed by Measuring Responses to Defined Thermal Stimuli
J. Neurosci., July 1, 2002; 22(13): 5727 - 5733.
[Abstract] [Full Text] [PDF]
F. W. Grasso
Invertebrate-Inspired Sensory-Motor Systems and Autonomous, Olfactory-Guided Exploration
Biol. Bull., April 1, 2001; 200(2): 160 - 168.
[Abstract] [Full Text] [PDF]
P. Yang, S. A. Shaver, A. J. Hilliker, and M. B. Sokolowski
Abnormal Turning Behavior in Drosophila Larvae: Identification and Molecular Analysis of scribbler (sbb)
Genetics, July 1, 2000; 155(3): 1161 - 1174.
[Abstract] [Full Text]
|
|
|
|
 |
|