 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, November 1, 1999, 19(21):9570-9578
Auditory Thalamus, Dorsal Hippocampus, Basolateral Amygdala, and Perirhinal Cortex Role in the Consolidation of Conditioned Freezing to Context and to Acoustic Conditioned Stimulus in the Rat
Benedetto Sacchetti, Carlo Ambrogi Lorenzini, Elisabetta Baldi, Giovanna Tassoni, and Corrado Bucherelli Dipartimento di Scienze Fisiologiche, Viale G.B. Morgagni 63, I-50134 Florence, Italy
On the basis of previous experimental evidence, it is known that the auditory thalamus (AT), the dorsal hippocampus (DH), the basolateral amygdala (BLA), and the perirhinal cortex (PC) are involved in the mnemonic processing of conditioned freezing. In particular, BLA and PC appear to be involved both in conditioned stimulus (CS) and context conditioned freezing. Through AT, the auditory CS is sent to other sites, whereas DH is involved in context conditioning. Nevertheless, the existing evidence does not make it possible to assess AT, DH, BLA, and PC involvement during the consolidation phase of conditioned freezing. To address this question, fully reversible tetrodotoxin (TTX) inactivation was performed on adult male Wistar rats having undergone CS and context fear training. Anesthetized animals were injected stereotaxically with TTX (either 5 or 10 ng in 0.5 or 1.0 µl of saline, according to site dimensions) at increasing post-acquisition delays. Context and CS freezing durations were measured during retention testing, always performed 48 and 72 hr after TTX administration. The results showed that AT inactivation does not disrupt consolidation of either contextual or auditory fear memories. In contrast, inactivation of the other three structures disrupted consolidation. For the DH, this disruption was specific to contextual cues and only occurred when inactivation was performed early (up to 1.5 hr) after training. The BLA and PC were shown to be involved in the consolidation of both contextual and auditory fear. Their involvement persisted for longer periods of time (2 d for BLA and 8 d for PC). These findings provide information to build a temporal profile for the post-training processing of fear memories in structures known to be important for this form of learning. The results are discussed in relation to previous studies on conditioned freezing and other aversive conditioned response neural correlates.
Key words: reversible tetrodotoxin inactivation; CS and context freezing; consolidation; auditory thalamus; dorsal hippocampus; basolateral amygdala; perirhinal cortex
Copyright © 1999 Society for Neuroscience 0270-6474/99/19219570-09$05.00/0
This article has been cited by other articles:
E. Baldi, C. Mariottini, and C. Bucherelli
The role of the nucleus basalis magnocellularis in fear conditioning consolidation in the rat
Learn. Mem., December 17, 2007; 14(12): 855 - 860.
[Abstract] [Full Text] [PDF]
S. C. Furtak, T. A. Allen, and T. H. Brown
Single-Unit Firing in Rat Perirhinal Cortex Caused by Fear Conditioning to Arbitrary and Ecological Stimuli
J. Neurosci., November 7, 2007; 27(45): 12277 - 12291.
[Abstract] [Full Text] [PDF]
A. C. Medina, J. R. Charles, V. Espinoza-Gonzalez, O. Sanchez-Resendis, R. A. Prado-Alcala, B. Roozendaal, and G. L. Quirarte
Glucocorticoid administration into the dorsal stratium facilitates memory consolidation of inhibitory avoidance training but not of the context or footshock components
Learn. Mem., October 1, 2007; 14(10): 673 - 677.
[Abstract] [Full Text] [PDF]
C. Bucherelli, E. Baldi, C. Mariottini, M. B. Passani, and P. Blandina
Aversive memory reactivation engages in the amygdala only some neurotransmitters involved in consolidation
Learn. Mem., July 1, 2006; 13(4): 426 - 430.
[Abstract] [Full Text] [PDF]
E. L. Malin and J. L. McGaugh
Differential involvement of the hippocampus, anterior cingulate cortex, and basolateral amygdala in memory for context and footshock
PNAS, February 7, 2006; 103(6): 1959 - 1963.
[Abstract] [Full Text] [PDF]
B. Sacchetti, B. Scelfo, and P. Strata
The Cerebellum: Synaptic Changes and Fear Conditioning
Neuroscientist, June 1, 2005; 11(3): 217 - 227.
[Abstract] [PDF]
J. G. Pelletier, E. Likhtik, M. Filali, and D. Pare
Lasting increases in basolateral amygdala activity after emotional arousal: Implications for facilitated consolidation of emotional memories
Learn. Mem., March 1, 2005; 12(2): 96 - 102.
[Abstract] [Full Text] [PDF]
R. D. Burwell, D. J. Bucci, M. R. Sanborn, and M. J. Jutras
Perirhinal and Postrhinal Contributions to Remote Memory for Context
J. Neurosci., December 8, 2004; 24(49): 11023 - 11028.
[Abstract] [Full Text] [PDF]
D. Pare, G. J. Quirk, and J. E. Ledoux
New Vistas on Amygdala Networks in Conditioned Fear
J Neurophysiol, July 1, 2004; 92(1): 1 - 9.
[Abstract] [Full Text] [PDF]
R. D. Burwell, M. P. Saddoris, D. J. Bucci, and K. A. Wiig
Corticohippocampal Contributions to Spatial and Contextual Learning
J. Neurosci., April 14, 2004; 24(15): 3826 - 3836.
[Abstract] [Full Text] [PDF]
P. Blandina, M. Efoudebe, G. Cenni, P. Mannaioni, and M. B. Passani
Acetylcholine, Histamine, and Cognition: Two Sides of the Same Coin
Learn. Mem., January 1, 2004; 11(1): 1 - 8.
[Full Text] [PDF]
M. G. Giovannini, M. Efoudebe, M. B. Passani, E. Baldi, C. Bucherelli, F. Giachi, R. Corradetti, and P. Blandina
Improvement in Fear Memory by Histamine-Elicited ERK2 Activation in Hippocampal CA3 Cells
J. Neurosci., October 8, 2003; 23(27): 9016 - 9023.
[Abstract] [Full Text] [PDF]
R. T. LaLumiere, T.-V. Buen, and J. L. McGaugh
Post-Training Intra-Basolateral Amygdala Infusions of Norepinephrine Enhance Consolidation of Memory for Contextual Fear Conditioning
J. Neurosci., July 30, 2003; 23(17): 6754 - 6758.
[Abstract] [Full Text] [PDF]
P. SAH, E. S. L. FABER, M. LOPEZ DE ARMENTIA, and J. POWER
The Amygdaloid Complex: Anatomy and Physiology
Physiol Rev, July 1, 2003; 83(3): 803 - 834.
[Abstract] [Full Text] [PDF]
H. Lehmann, D. Treit, and M. B. Parent
Spared Anterograde Memory for Shock-Probe Fear Conditioning After Inactivation of the Amygdala
Learn. Mem., July 1, 2003; 10(4): 261 - 269.
[Abstract] [Full Text] [PDF]
D. J. Howse, A. S. Squires, G. M. Martin, and D. M. Skinner
Perirhinal Cortex Lesions Impair Context Aversion Learning
Learn. Mem., May 1, 2003; 10(3): 161 - 167.
[Abstract] [Full Text] [PDF]
L. H. Corbit, S. B. Ostlund, and B. W. Balleine
Sensitivity to Instrumental Contingency Degradation Is Mediated by the Entorhinal Cortex and Its Efferents via the Dorsal Hippocampus
J. Neurosci., December 15, 2002; 22(24): 10976 - 10984.
[Abstract] [Full Text] [PDF]
A. Vazdarjanova
Chasing "fear memories" to the cerebellum
PNAS, June 11, 2002; 99(12): 7814 - 7815.
[Full Text] [PDF]
B. Sacchetti, E. Baldi, C. A. Lorenzini, and C. Bucherelli
From the Cover: Cerebellar role in fear-conditioning consolidation
PNAS, June 11, 2002; 99(12): 8406 - 8411.
[Abstract] [Full Text] [PDF]
G. M. Muir and D. K. Bilkey
Instability in the Place Field Location of Hippocampal Place Cells after Lesions Centered on the Perirhinal Cortex
J. Neurosci., June 1, 2001; 21(11): 4016 - 4025.
[Abstract] [Full Text] [PDF]
E. H. Baeg, Y. B. Kim, J. Jang, H. T. Kim, I. Mook-Jung, and M. W. Jung
Fast Spiking and Regular Spiking Neural Correlates of Fear Conditioning in the Medial Prefrontal Cortex of the Rat
Cereb Cortex, May 1, 2001; 11(5): 441 - 451.
[Abstract] [Full Text] [PDF]
A. E. Wilensky, G. E. Schafe, and J. E. LeDoux
The Amygdala Modulates Memory Consolidation of Fear-Motivated Inhibitory Avoidance Learning But Not Classical Fear Conditioning
J. Neurosci., September 15, 2000; 20(18): 7059 - 7066.
[Abstract] [Full Text] [PDF]
D. Pare and D. R. Collins
Neuronal Correlates of Fear in the Lateral Amygdala: Multiple Extracellular Recordings in Conscious Cats
J. Neurosci., April 1, 2000; 20(7): 2701 - 2710.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|