QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (50) Citing Articles via Google Scholar Google Scholar Articles by Baker, J. T. Articles by Sanes, J. N. Search for Related Content PubMed PubMed Citation Articles by Baker, J. T. Articles by Sanes, J. N.

 Previous Article  |  Next Article 

The Journal of Neuroscience, November 15, 1999, 19(22):10044-10052

Gaze Direction Modulates Finger Movement Activation Patterns in Human Cerebral Cortex

Justin T. Baker¹, John P. Donoghue¹, and Jerome N. Sanes^{1, 2}

¹ Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, and ² Scientific Institute Santa Lucia, 00179 Rome, Italy

We investigated whether gaze direction modified the pattern of finger movement activation in human cerebral cortex using functional magnetic resonance imaging (MRI). Participants performed a sequential finger-tapping task or made no finger movements while maintaining gaze in the direction of the moving hand (aligned conditions) or away from the location of the moving hand. Functional MR signals, measured in the hemisphere contralateral to the moving hand, revealed finger movement-related activation in primary motor cortex, lateral and medial premotor cortex, and a wide extent of the lateral superior and inferior parietal lobules. In each area, the extent of the finger movement activation increased when static gaze was more aligned with the moving hand compared to when gaze was directed away from the moving hand. These data suggest the existence of large-scale cortical networks related to finger actions and indicate that skeletomotor processing in the cerebral cortex is consistently modified by gaze direction signals.

Key words: functional magnetic resonance imaging; voluntary hand movement; eye position; motor cortical networks; cerebral cortex; oculcomotor-skeletomotor interactions

---

Copyright © 1999 Society for Neuroscience  0270-6474/99/192210044-09$05.00/0

This article has been cited by other articles:

				J. L. Gardner, E. P. Merriam, J. A. Movshon, and D. J. Heeger Maps of Visual Space in Human Occipital Cortex Are Retinotopic, Not Spatiotopic J. Neurosci., April 9, 2008; 28(15): 3988 - 3999. [Abstract] [Full Text] [PDF]

				W. Truccolo, G. M. Friehs, J. P. Donoghue, and L. R. Hochberg Primary Motor Cortex Tuning to Intended Movement Kinematics in Humans with Tetraplegia J. Neurosci., January 30, 2008; 28(5): 1163 - 1178. [Abstract] [Full Text] [PDF]

				M. Tanaka Spatiotemporal Properties of Eye Position Signals in the Primate Central Thalamus Cereb Cortex, July 1, 2007; 17(7): 1504 - 1515. [Abstract] [Full Text] [PDF]

				L. Ren, A. Z. Khan, G. Blohm, D.Y.P. Henriques, L. E. Sergio, and J. D. Crawford Proprioceptive Guidance of Saccades in Eye-Hand Coordination J Neurophysiol, September 1, 2006; 96(3): 1464 - 1477. [Abstract] [Full Text] [PDF]

				M. Rijntjes, V. Hobbeling, F. Hamzei, S. Dohse, G. Ketels, J. Liepert, and C. Weiller Individual Factors in Constraint-Induced Movement Therapy after Stroke Neurorehabil Neural Repair, September 1, 2005; 19(3): 238 - 249. [Abstract] [PDF]

				K. Stefan, M. Wycislo, and J. Classen Modulation of Associative Human Motor Cortical Plasticity by Attention J Neurophysiol, July 1, 2004; 92(1): 66 - 72. [Abstract] [Full Text] [PDF]

				S. C. Cramer Editorial Comment--Implementing Results of Stroke Recovery Research Into Clinical Practice Stroke, July 1, 2003; 34(7): 1752 - 1753. [Full Text] [PDF]

				I. Derakhshan and A. Riestra Is the middle between both halves? Midpoint location and segment size estimation in neglect Neurology, April 8, 2003; 60(7): 1221 - 1221. [Full Text] [PDF]

				J. F.X. DeSouza, S. P. Dukelow, and T. Vilis Eye Position Signals Modulate Early Dorsal and Ventral Visual Areas Cereb Cortex, September 1, 2002; 12(9): 991 - 997. [Abstract] [Full Text] [PDF]

				F. Binkofski, G. R. Fink, S. Geyer, G. Buccino, O. Gruber, N. J. Shah, J. G. Taylor, R. J. Seitz, K. Zilles, and H.-J. Freund Neural Activity in Human Primary Motor Cortex Areas 4a and 4p Is Modulated Differentially by Attention to Action J Neurophysiol, July 1, 2002; 88(1): 514 - 519. [Abstract] [Full Text] [PDF]

				S C Cramer, E Fray, A Tievsky, R A Parker, P N Riskind, M C Stein, V Wedeen, and B R Rosen Changes in motor cortex activation after recovery from spinal cord inflammation Multiple Sclerosis, December 1, 2001; 7(6): 364 - 370. [Abstract] [PDF]

				N. Sawamoto, M. Honda, T. Okada, T. Hanakawa, M. Kanda, H. Fukuyama, J. Konishi, and H. Shibasaki Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study J. Neurosci., October 1, 2000; 20(19): 7438 - 7445. [Abstract] [Full Text] [PDF]

				P. Van Donkelaar, J.-H. Lee, and A. S. Drew Transcranial Magnetic Stimulation Disrupts Eye-Hand Interactions in the Posterior Parietal Cortex J Neurophysiol, September 1, 2000; 84(3): 1677 - 1680. [Abstract] [Full Text] [PDF]

				J. F. X. DeSouza, S. P. Dukelow, J. S. Gati, R. S. Menon, R. A. Andersen, and T. Vilis Eye Position Signal Modulates a Human Parietal Pointing Region during Memory-Guided Movements J. Neurosci., August 1, 2000; 20(15): 5835 - 5840. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help