QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (56) Citing Articles via Google Scholar Google Scholar Articles by Yoshida, N. Articles by Liberman, M. C. Search for Related Content PubMed PubMed Citation Articles by Yoshida, N. Articles by Liberman, M. C.

 Previous Article  |  Next Article 

The Journal of Neuroscience, November 15, 1999, 19(22):10116-10124

Heat Stress and Protection from Permanent Acoustic Injury in Mice

Naohiro Yoshida^{1, 2, 3}, Arthur Kristiansen^{1, 2}, and M. Charles Liberman^{1, 2}

¹ Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, ² Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, and ³ Department of Otolaryngology, Tohoku University, Graduate School of Medicine, Sendai, 980-8574 Japan

The inner ear can be permanently damaged by overexposure to high-level noise; however, damage can be decreased by previous exposure to moderate level, nontraumatic noise (Canlon et al., 1988). The mechanism of this "protective" effect is unclear, but a role for heat shock proteins has been suggested. The aim of the present study was to directly test protective effects of heat stress in the ear. For physiological experiments, CBA/CaJ mice were exposed to an intense octave band of noise (8-16 kHz) at 100 dB SPL for 2 hr, either with or without previous whole-body heat stress (rectal temperature to 41.5 °C for 15 min). The interval between heat stress and sound exposure varied in different groups from 6 to 96 hr. One week later, inner ear function was assessed in each animal via comparison of compound action potential thresholds to mean values from unexposed controls. Permanent threshold shifts (PTSs) were ~40 dB in the group sound-exposed without previous heat stress. Heat-stressed animals were protected from acoustic injury: mean PTS in the group with 6 hr heat-stress-trauma interval was reduced to ~10 dB. This heat stress protection disappeared when the treatment-trauma interval surpassed 24 hr. A parallel set of quantitative PCR experiments measured heat-shock protein mRNA in the cochlea and showed 100- to 200-fold increase over control 30 min after heat treatment, with levels returning to baseline at 6 hr after treatment. Results are consistent with the idea that upregulation of heat shock proteins protects the ear from acoustic injury.

Key words: sound conditioning; acoustic trauma; cochlea; hearing; heat shock; quantitative PCR

---

Copyright © 1999 Society for Neuroscience  0270-6474/99/192210116-09$05.00/0

This article has been cited by other articles:

				A. Hossain, K. Hajman, K. Charitidi, S. Erhardt, U. Zimmermann, M. Knipper, and B. Canlon Prenatal Dexamethasone Impairs Behavior and the Activation of the BDNF Exon IV Promoter in the Paraventricular Nucleus in Adult Offspring Endocrinology, December 1, 2008; 149(12): 6356 - 6365. [Abstract] [Full Text] [PDF]

				S. F. Maison, L. L. Parker, L. Young, J. P. Adelman, J. Zuo, and M. C. Liberman Overexpression of SK2 Channels Enhances Efferent Suppression of Cochlear Responses Without Enhancing Noise Resistance J Neurophysiol, April 1, 2007; 97(4): 2930 - 2936. [Abstract] [Full Text] [PDF]

				Y. Tahera, I. Meltser, P. Johansson, A. C. Hansson, and B. Canlon Glucocorticoid Receptor and Nuclear Factor-{kappa}B Interactions in Restraint Stress-Mediated Protection against Acoustic Trauma Endocrinology, September 1, 2006; 147(9): 4430 - 4437. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help